Gamma-ray sterilization and its effect on intraocular lenses

Meltzer, David W.

doi:10.1016/s0146-2776(81)80057-2

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…Die Aufbewahrung und Umfullung von feucht-sterilisierten (NaOH/ NaHCO3) Linsen hat in einigen Fallen eine Pilzkontamination nach sich gezogen (Mosier und Mitarb., 1977;Pettit und Mitarb., 1980 Tage nach der Operation auftrat (Stark und Mitarb., 1980, 1982Boyaner und Solomon, 1980). Berichte ahnlich ungünstige Folgen der Gamma-Sterilisierung betrafen solche Linsen, die in einem flUssigen Medium (BSS) aufbewahrt und sterilisiert worden waren (Meltzer, 1981). Meines Wissens werden die meistender jetzt verwendeten intraokularen Linsen entweder mit A thylenoxyd oder mit Gamma-Strahien sterilisiert.…”

Section: Intraocular Inflammatory Reactions After Posterior Chamber Lunclassified

Intraokulare Entzündungsreaktionen nach Implantation einer retropupillaren Linse*

Böke¹

1987

Klin Monatsbl Augenheilkd

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The implantation of an artificial lens into the retropupillary space, be it the sulcus ciliaris or the capsular bag, has proved to be a safe procedure in the vast majority of cases. However, posterior chamber lens implantation invariable provokes some intraocular inflammatory reaction, though in general only a clinically insignificant one. Occasionally, serious reactions may occur, such as fibrinous exsudates, "toxic lens syndrome", UGH syndrome, and the "intermittent white-out" syndrome. Lens-induced, IOL-induced, or even microbe-induced uveitis or endophthalmitis have also been seen. The clinical pictures of such complications are described. Prophylaxis and appropriate therapeutic measures are outlined. With regard to postoperative inflammatory reactions whose etiology is unclear, the potential role of the following factors is discussed: lens material, lens manufacturing technology, sterilization, and sulcus fixation vs. capsule fixation. Presently, there is no evidence of any obvious relationship between these factors and major inflammatory responses. However, patients suffering from glaucoma, diabetes, or uveitis seem to be more prone to significant postoperative reactions than others. Generally, in cases of unusual intraocular inflammation following posterior chamber lens implantation, the various clinical pictures described here should be taken into consideration. The possibility of a slowly developing microbe-induced endophthalmitis should not be overlooked.

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Section: Intraocular Inflammatory Reactions After Posterior Chamber Lunclassified

Intraokulare Entzündungsreaktionen nach Implantation einer retropupillaren Linse*

Böke¹

1987

Klin Monatsbl Augenheilkd

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Particulate Contamination in Disposable Corneal Trephines

Pardos¹,

Meltzer²

1983

Archives of Ophthalmology

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Electron Beam Sterilization of Poly(Methyl Methacrylate)—Physicochemical and Biological Aspects

Sharifi

Islam

Sharifi

et al. 2021

Macromolecular Bioscience

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Electron beam (E‐beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E‐beam sterilization on the intrinsic properties of PMMA is vital for clinical implementation. A detailed assessment of the chemical, optical, mechanical, morphological, and biological properties of medical‐grade PMMA after E‐beam sterilization at 25 and 50 kiloGray (kGy) is reported. Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry studies indicate that E‐beam irradiation has minimal effect on the chemical properties of the PMMA at these doses. While 25 kGy irradiation does not alter the mechanical and optical properties of the PMMA, 50 kGy reduces the flexural strength and transparency by 10% and 2%, respectively. Atomic force microscopy demonstrates that E‐beam irradiation reduces the surface roughness of PMMA in a dose dependent manner. Live‐Dead, AlamarBlue, immunocytochemistry, and complement activation studies show that E‐beam irradiation up to 50 kGy has no adverse effect on the biocompatibility of the PMMA. These findings suggest that E‐beam irradiation at 25 kGy may be a safe and efficient alternative for PMMA sterilization.

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Gamma-ray sterilization and its effect on intraocular lenses

Cited by 9 publications

References 4 publications

Intraokulare Entzündungsreaktionen nach Implantation einer retropupillaren Linse*

Intraokulare Entzündungsreaktionen nach Implantation einer retropupillaren Linse*

Particulate Contamination in Disposable Corneal Trephines

Electron Beam Sterilization of Poly(Methyl Methacrylate)—Physicochemical and Biological Aspects

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