Paper sheets represent one of the infection risk sources inside many institutions. The present study aimed to validate the sterilization efficiency of contaminated paper sheets with different indicator pathogens by gamma radiation or dry heat technique with retaining their structure. The results show that gamma irradiation at 6 kGy, 12 kGy, and 24 kGy can successfully kill Gram-positive bacteria like Bacillus cereus and Staphylococcus aureus, Gram-negative bacteria like Escherichia Coli and Salmonella typhi, and fungi such as Candida albicans. Moreover, dry heat at 100°C for 1 hour, 150 for 30 min, or 200 for 15 min can be successful in paper decontamination completely all tested species. Surprise, micrographs of scanning electron microscope (SEM) proved that a radiation dose of 6 kGy, dry heat at 100°C for 1 hour, 150 for 30 min or 200 for 15 min is suitable for paper sheets sterilization with maintaining their structure. Ultimately, dry heat or γ-radiation as simple, useful, effective, fast, safe, and inexpensive techniques. It may be used as a precautionary step inside educational institutions especially, during written examinations period to ensure safe life for academic members during biological pandemics like covid-19.