Abstract:Non-invasive sensory stimulation in the range of the brain’s gamma
rhythm (30-100 Hz) is emerging as a new potential therapeutic strategy
for the treatment of Alzheimer’s disease (AD). Here we investigated the
effect of repeated combined exposure to 40 Hz synchronized sound and
light stimuli on hippocampal long-term potentiation (LTP) in vivo in
three rat models of early AD. We employed a very complete model of AD
amyloidosis, amyloid precursor protein (APP)-overexpressing transgenic
McGill-R-Thy1-APP rats at … Show more
“…Previous findings, by our lab and others, have shown effects of 40 Hz stimulation on a wide array of phenotypes in neurodegenerative disease, including protein clearance, synaptic potentiation, autophagy, glial activation, inflammatory changes, and vascular responses [1][2][3]7,8,25,26 . These effects may be indirect from the neural response to gamma stimulation, but it is unclear how neural response to sensory stimulation is coupled to biological pathways related to pathology.…”
Section: Cellular Effects Of Stimulation Evoked Responsesmentioning
Findings by the Tsai lab and others1–8demonstrate that 40 Hz frequency sensory stimulation induces electrophysiological responses and attenuates pathology in mouse models of Alzheimer’s disease (AD). A recent study inNature Neurosciene9concluded that the stimulation does not affect endogenous gamma oscillations or amyloid burden. We welcome research investigating 40 Hz sensory stimulation, and the article by Soula et al enhances our understanding of the brain’s electrophysiological response to 40Hz. However, we respectfully suggest that the data in Soula et al are consistent with a neuronal response to 40 Hz, which we further support with new data in humans. Moreover we contend the non-significant effects on amyloid are due to technical limitations of the study.
“…Previous findings, by our lab and others, have shown effects of 40 Hz stimulation on a wide array of phenotypes in neurodegenerative disease, including protein clearance, synaptic potentiation, autophagy, glial activation, inflammatory changes, and vascular responses [1][2][3]7,8,25,26 . These effects may be indirect from the neural response to gamma stimulation, but it is unclear how neural response to sensory stimulation is coupled to biological pathways related to pathology.…”
Section: Cellular Effects Of Stimulation Evoked Responsesmentioning
Findings by the Tsai lab and others1–8demonstrate that 40 Hz frequency sensory stimulation induces electrophysiological responses and attenuates pathology in mouse models of Alzheimer’s disease (AD). A recent study inNature Neurosciene9concluded that the stimulation does not affect endogenous gamma oscillations or amyloid burden. We welcome research investigating 40 Hz sensory stimulation, and the article by Soula et al enhances our understanding of the brain’s electrophysiological response to 40Hz. However, we respectfully suggest that the data in Soula et al are consistent with a neuronal response to 40 Hz, which we further support with new data in humans. Moreover we contend the non-significant effects on amyloid are due to technical limitations of the study.
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