Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/b-catenin signaling pathway

Wang, Yan; Shi, Jian; Gong, Liya

doi:10.5603/fhc.a2020.0012

Cited by 12 publications

(9 citation statements)

References 43 publications

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“… Cell line A useful adjunct to primary tamoxifen [47] . Gastric cancer Human Inhibit hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transformation by inhibiting the Wnt/b-catenin signaling pathway [48] . Colon cancer Cell line Inhibit tumour-matrix adhesion via the inhibition of FAK and paxillin tyrosine phosphorylation [49] .…”

Section: Resultsmentioning

confidence: 99%

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

Fu,

Li,

Wang

et al. 2024

ABBS

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DPP3, a dipeptidyl peptidase, participates in a variety of pathophysiological processes. DPP3 is upregulated in cancer and might serve as a key factor in the tumorigenesis and progression of various malignancies. However, its specific role and molecular mechanism are still unknown. In this study, the expression of DPP3 in breast cancer tissues is analyzed using TCGA database. Kaplan-Meier survival analysis is performed to estimate the effect of DPP3 on the survival outcomes. To explore the biological function and mechanisms of DPP3 in breast cancer, biochemical and cell biology assays are conducted in vitro . DPP3 expresses at a higher level in breast cancer tissues than that in adjacent tissues in both TCGA database and clinical samples. Patients with high expression of DPP3 have poor survival outcomes. The proliferation and migration abilities of tumor cells with stable DPP3 knockout in breast cancer cell lines are significantly inhibited, and apoptosis is increased in vitro . GSEA analysis shows that DPP3 can affect lipid metabolism and fatty acid synthesis in tumors. Subsequent experiments show that DPP3 could stabilize FASN expression and thus promote fatty acid synthesis in tumor cells. The results of the metabolomic analysis also confirm that DPP3 can affect the content of free fatty acids. This study demonstrates that DPP3 plays a role in the reprogramming of fatty acid metabolism in tumors and is associated with poor prognosis in breast cancer patients. These findings will provide a new therapeutic target for the treatment of breast cancer.

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Section: Resultsmentioning

confidence: 99%

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

Fu,

Li,

Wang

et al. 2024

ABBS

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“…In addition, GLA has been reported to decrease the expression of the metastasis-associated protein osteonectin (or SPARC) and increase the expression of metastasis suppressor genes to inhibit tumor metastasis. GLA could also decrease the β-catenin expression of Wnt/b-catenin signaling pathway to inhibit gastric cancer cell growth and EMT induced by hypoxia ( 30 ). Additionally, polyunsaturated fatty acids, including GLA, could induce an apoptosis of colon cancer cells ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling identifies biomarkers and metabolic impacts of surgery for colorectal cancer

et al. 2022

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BackgroundColorectal cancer (CRC) is one of the most common malignant tumors with recurrence and metastasis after surgical resection. This study aimed to identify the physiological changes after surgery and explore metabolites and metabolic pathways with potential prognostic value for CRC.MethodsAn ultra-high-performance liquid chromatography Q-exactive mass spectrometry was used to profile serum metabolites from 67 CRC patients and 50 healthy volunteers. Principal component analysis (PCA) and orthogonal projections to latent structures-discriminant analysis were used to distinguish the internal characteristics of data in different groups. Multivariate statistics were compiled to screen the significant metabolites and metabolic pathways.ResultA total of 180 metabolites were detected. Under the conditions of variable importance in projection >1 and p-value <0.05, 46 differentially expressed metabolites were screened for further pathway enrichment analysis. Based on the Kyoto Encyclopedia of Genes and Genomes database and Small Molecule Pathway Database, three metabolic pathways—arginine and proline metabolism, ascorbate and aldarate metabolism, and phenylalanine metabolism—were significantly altered after surgical resection and identified as associated with the removal of CRC. Notably, gamma-linolenic acid was upregulated in the CRC preoperative patients compared with those in healthy volunteers but returned to healthy levels after surgery.ConclusionThrough serum-based metabolomics, our study demonstrated the differential metabolic characteristics in CRC patients after surgery compared with those before surgery. Our results suggested that metabonomic analysis may be a powerful method for exploring physiological alterations in CRC patients after surgery as well as a useful tool for identifying candidate biomarkers and monitoring disease recurrence.

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“…In addition, bufalin, a bioactive polyhydroxy steroid compound isolated from Venenum Bufonis, induced apoptosis of AGS by down-regulating Wnt/ASCL2 expression (Wang, Cai, et al, 2018b). Furthermore, gamma linolenic acid, a naturally occurring omega-6 unsaturated fatty acid, induced the apoptosis of SGC-7901 and MGC-803 by inhibiting Wnt/β-catenin signaling pathway (Wang, Shi, & Gong, 2020c). Therefore, subsequent studies should focus on the effect of natural products targeting the Wnt/β-catenin signaling to curb GC.…”

Section: Berberine Was Identified To Induce Apoptosis Of Gc Cells By ...mentioning

confidence: 99%

Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives

et al. 2023

Phytotherapy Research

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Gastric cancer (GC) is one of the most serious gastrointestinal malignancies with high morbidity and mortality. The complexity of GC process lies in the multi‐phenotypic linkage regulation, in which regulatory cell death (RCD) is the core link, which largely dominates the fate of GC cells and becomes a key determinant of GC development and prognosis. In recent years, increasing evidence has been reported that natural products can prevent and inhibit the development of GC by regulating RCDs, showing great therapeutic potential. In order to further clarify its key regulatory characteristics, this review focused on specific expressions of RCDs, combined with a variety of signaling pathways and their crosstalk characteristics, sorted out the key targets and action rules of natural products targeting RCD. It is highlighted that a variety of core biological pathways and core targets are involved in the decision of GC cell fate, including the PI3K/Akt signaling pathway, MAPK‐related signaling pathways, p53 signaling pathway, ER stress, Caspase‐8, gasdermin D (GSDMD), and so on. Moreover, natural products target the crosstalk of different RCDs by modulating above signaling pathways. Taken together, these findings suggest that targeting various RCDs in GC with natural products is a promising strategy, providing a reference for further clarifying the molecular mechanism of natural products treating GC, which warrants further investigations in this area.

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Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/b-catenin signaling pathway

Cited by 12 publications

References 43 publications

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

Metabolomic profiling identifies biomarkers and metabolic impacts of surgery for colorectal cancer

Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives

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