Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver

Segarnick, David J.; Cordasco, Donna Mandio; Agura, V; Cooper, Norman S.; Rotrosen, John

doi:10.1016/0262-1746(85)90116-7

Cited by 17 publications

(3 citation statements)

References 11 publications

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“…The hepatoprotective properties of GLA are poorly described. γ‐Linoleic acid methyl ester attenuated an increase of hepatic triglycerides but did not affect the liver histology evaluated as hepatocyte vacuolization in rats treated with ethanol in a 10‐day experiment (Segarnick et al ., ). γ‐Linoleic acid improved fatty liver induced by conjugated linoleic acid in mice that is associated with the increase of hepatic prostaglandin E 2 level (Nakanishi et al ., ) and completely prevented liver triacylglyceride accumulation induced by the essential fatty acids‐free diet.…”

Section: Introductionmentioning

confidence: 97%

Reversal of Experimental Ethanol‐induced Liver Steatosis by Borage Oil

Lukivskaya

Naruta

Sadovnichy

et al. 2012

Phytotherapy Research

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The aim of study was to evaluate the hepatoprotective effect of borage oil containing predominantly gamma-linolenic acid in rats with alcoholic steatohepatitis. Liver of ethanol-treated animals was characterized by fatty and hydropic dystrophies. Liver triglyceride contents and activitiies of serum marker enzymes were significantly increased. Ethanol increased nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)-induced chemiluminescence and the contents of liver thiobarbituric acid reactive substances (TBARS). The reduced glutathione content in the liver was decreased. Ethanol enhanced liver microsomal cytochrome P-450 (CYP450) content, aniline p-hydroxylase and amydopyrine-N-demethylase activities. The treatment with borage oil improved the liver morphology, decreased triglyceride contents and normalized serum marker enzyme activities. Borage oil developed an antioxidant effect in ethanol-treated rats. The treatment with this compound decreased NADPH-induced chemiluminescence and the content of lipid peroxidation products. Borage oil normalized CYP450 content compared with the ethanol-treated group. CYPI450 2E1 isoform is a main source of free oxygen radicals in the liver of ethanol-treated rats and we propose that the antioxidant effect of borage oil is realized via the normalization of CYP450 content and activities of CYP450-related microsomal oxidases, as borage oil can improve the lipid surrounding of CYP450. In our opinion, the hepatoprotection by borage oil in alcoholic steatosis is connected with its antioxidant properties.

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Section: Introductionmentioning

confidence: 97%

Reversal of Experimental Ethanol‐induced Liver Steatosis by Borage Oil

Lukivskaya

Naruta

Sadovnichy

et al. 2012

Phytotherapy Research

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“…Diets containing oil from evening primrose (Oenothera biennis) have been suggested for prevention of various diseases (24), including those caused by ethanol (8,9), and the active component is considered to be y-linolenic acid. The methyl ester of this attenuates the ethanol-induced fatty liver when administered intraperitoneally (8,25). Since off from Borago officinalis has more than twice the y-linolenic acid content of evening primrose oil (9), it was chosen for the present study.…”

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confidence: 99%

Influence of dietary fats on pancreatic phospholipids of chronically ethanol‐treated rats

Cronholm¹,

Neri²,

Karpe³

et al. 1988

Lipids

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Male rats were given liquid diets by pair-feeding for 24-30 days, and phosphatidylinositols in pancreas were analyzed as derivatives of diacylglycerols and fatty acids. Addition of arachidonic acid or changing the fat component (35 energy %) in the liquid diet from olive oil/corn oil to oil from Borago officinalis, which contains 22% gamma-linolenic acid, increased the fraction of arachidonoyl-containing species. This fraction was decreased by more than 50% by substituting ethanol for 36 of the 47 energy% provided by carbohydrate. A smaller difference between ethanol-fed and control rats was seen in the composition of phosphatidylcholines and phosphatidylethanolamines. There was no difference in the composition of phosphatidylinositols when fat, instead of ethanol, was used to substitute the 36 energy % in the diet containing olive oil/corn oil. Substituting ethanol for 28 of 35 energy% provided by fat as corn oil in a liquid diet had no effect on the fraction of arachidonoyl-containing species. The results indicate that the effect of ethanol on phosphatidylinositols in pancreas is not due to a deficiency of arachidonic acid, and that the effect of the ethanol-containing diet is not due to the lowered carbohydrate content. However, high contents of fat or of ethanol appear to be necessary for the effect.

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“…Unluckily, the hepatoprotective characteristics of borage oil rich in GLA are poorly described. Although GLA reduced the increase lipids in hepatocytes, it did not affect the liver histology in rats treated with ethanol (12).…”

Section: Introductionmentioning

confidence: 71%

Altın Suriye Hamsterlarında Hiperlipidemik Diyet ile Oluşturulan Karaciğer Hasarı Üzerine Hodan Yağının Etkileri

Alhilal¹,

Alhilal²,

Albaz³

2019

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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This study was designed to examine the hepatoprotective effects of Borage seed oil rich in Gamma Linolenic acid (GLA) against hyperlipidemic diet-induced liver damage in the male golden Syrian hamster. In this experiment a total of 60 animals of male hamsters were used. This experiment was carried out in 2 periods. The first period lasted 4 weeks, in which hamsters were segregated into 4 groups. S1 served as control (given a commercial rodent diet only). Other groups, S2, S3 and S4 were fed with a diet containing of %80 commercial rodent diet + 20% fats (Hyperlipidemic Diet). The second period lasted 4 weeks, in which S2 only that continued fed with hyperlipidemic diet. S4 was orally gavaged with borage oil at 2 g/kg of the body weight daily. Hyperlipidemic diet intake caused lipid accumulation in hepatocytes and significantly (P<0.05) increased the activities of ALT, AST, ALP, LDH, GGT and CK enzymes in each of the S2, S3 and S4 groups at the end of the first period. These negative effects were removed only in S4 by the use of borage oil.

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Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver

Cited by 17 publications

References 11 publications

Reversal of Experimental Ethanol‐induced Liver Steatosis by Borage Oil

Reversal of Experimental Ethanol‐induced Liver Steatosis by Borage Oil

Influence of dietary fats on pancreatic phospholipids of chronically ethanol‐treated rats

Altın Suriye Hamsterlarında Hiperlipidemik Diyet ile Oluşturulan Karaciğer Hasarı Üzerine Hodan Yağının Etkileri

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