Gamma knife stereotactic radiosurgery yields good long-term outcomes for low-volume uveal melanomas without intraocular complications

Toktaş, Zafer Orkun; Biçer, Atilla; Demirci, Gulden; Pazarlı, Halit; Abacıoğlu, Ufuk; Peker, Selçuk; Kılıç, Türker

doi:10.1016/j.jocn.2009.08.004

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…47 Gamma knife radiosurgery offers tumor control and complication rates comparable to brachytherapy. 48 Plaque brachytherapy (Fig.2) has evolved into a promising alternative to enucleation as it provides excellent local control with only a moderate reduction in visual acuity.…”

Section: Newer Indications For Radiotherapy: Hypofractionationmentioning

confidence: 99%

The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

Khan

Almasan

Singh

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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The incidence of melanoma is rising in the United States, leading to an estimated 68,720 new diagnoses and 8,650 deaths. The natural history involves metastases to lymph nodes, lung, liver, brain, and often to other sites. Primary treatment for melanoma is surgical excision of the primary tumor and affected lymph nodes. The role of adjuvant or definitive radiation therapy in the treatment of melanoma remains controversial, as melanoma has traditionally been viewed as a prototypical radioresistant cancer. However, recent studies suggest that under certain clinical circumstances, there may be a significant role for radiation therapy in melanoma treatment. Stereotactic radiosurgery for brain metastases has shown effective local control. High dose per fraction radiation therapy has been associated with a lower rate of locoregional recurrence of sinonasal melanoma. Plaque brachytherapy has evolved into a promising alternative to enucleation at the expense of moderate reduction in visual acuity. Adjuvant radiation therapy following lymphadenectomy in node positive melanoma prevents local and regional recurrence. The newer clinical data along with emerging radiobiological data indicate that radiotherapy is likely to play a greater role in melanoma management, and should be considered as a treatment option.

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Section: Newer Indications For Radiotherapy: Hypofractionationmentioning

confidence: 99%

The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

Khan

Almasan

Singh

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…The 3 types of retinal detachment that occur after GK therapy for CM are exudative retinal detachment due to the therapy itself, tractional retinal detachment resulting from scarred tumor lesions or proliferative membranes secondary to radiation retinopathy, and rhegmatogenous retinal detachment in which a retinal break can develop as the result of such traction [ 6 , 7 , 8 , 9 , 10 , 11 ]. The majority of previous studies have been related to exudative retinal detachment due to the GK therapy itself.…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been some previous reports of retinal detachment following GK therapy for CM, most of the cases in those studies were exudative retinal detachment [ 6 , 7 , 8 , 9 , 10 , 11 ]. Here, we report a case of radiation retinopathy after GK therapy that caused a rhegmatogenous retinal detachment at a later stage.…”

Section: Introductionmentioning

confidence: 99%

A Case of Retinal Detachment with Unique Optical Coherence Tomography Findings after Gamma Knife® Radiosurgery Treatment for Choroidal Melanoma

Kimura

Sato

Fukumoto

et al. 2018

Case Rep Ophthalmol

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Purpose: To report a case of retinal detachment with unique optical coherence tomography (OCT) findings after Gamma Knife® (GK; Elekta Instrument AB, Stockholm, Sweden) treatment for choroidal melanoma (CM). Case Report: A 48-year-old woman underwent GK therapy for CM in her right eye from the macula to the temporal side. While the tumor subsequently shrank, the patient developed radiation retinopathy, which was treated with laser photocoagulation. The tumor lesions later subsided; however, her visual acuity (VA) decreased 8 years after the initial treatment. Although the tumor lesions in the right eye had become scarred, a bullous retinal detachment with fixed folds occurred in the superior-nasal quadrants. OCT examination revealed a preretinal membrane, vitreoretinal traction, and an inner retinal break; however, no outer retinal break was clearly detectable. MRI scans showed no increase in tumorous lesions, and ¹²³I-IMP SPECT imaging showed no photon accumulation. Thus, it was determined that there was no tumor activity. The corrected VA in her right eye was light perception, and it was determined that there was no indication for vitreous surgery. Conclusion: In this case, an inner retinal break was formed by the vitreoretinal traction around the scarred tumor and radiation retinopathy, thus suggesting the possibility of the development of a rhegmatogenous retinal detachment presumably complicated with an outer retinal break.

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“…The effectiveness and adverse reactions are considered comparable between GammaKnife stereotactic radiosurgery, though dosimetric data suggests protons may confer a slightly decreased risk of second malignancies than photons when life expectancy is many decades [39][40][41][42].…”

Section: Stereotactic Radiosurgery (Gammaknife)mentioning

confidence: 99%

Teletherapy: Advanced Techniques

Stockham

Balagamwala

Singh

et al. 2013

Ophthalmic Radiation Therapy

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Radiotherapy has been utilized as a treatment for ophthalmologic processes for more than one hundred years. Over this century, the field of ophthalmologic oncology has been revolutionized through medical discoveries, development of novel surgical interventions, and innovation of advanced radiotherapy techniques. In this chapter, novel radiotherapy techniques are considered. Material presented will build on basic radiation therapy principles, techniques, and treatment parameters established in the previous chapter through consideration of intensity modulated radiotherapy, stereotactic radiotherapy, and heavy ion therapy. Deliberation of matters common across advanced radiotherapy techniques including target delineation, treatment planning, and requisites for ensuring accurate, precise treatment delivery will precede discussion of advanced radiotherapy techniques as applied to the management ophthalmologic malignancies.

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Gamma knife stereotactic radiosurgery yields good long-term outcomes for low-volume uveal melanomas without intraocular complications

Cited by 12 publications

References 23 publications

The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

A Case of Retinal Detachment with Unique Optical Coherence Tomography Findings after Gamma Knife® Radiosurgery Treatment for Choroidal Melanoma

Teletherapy: Advanced Techniques

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