Gamma Knife Radiosurgery (GKRS) in the Management of Parkinson's Disease and Essential Tremor: Long-term Follow-up Report of 192 Cases

Frentress, C.; Mark, Rufus J.; Smith, H.; Jacques, David; Young, Renée; Copcutt, Brian; Chen, C.; Anderson, Paul J.; Nair, Murali

doi:10.1016/j.ijrobp.2010.07.059

Cited by 2 publications

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“…8,10, 12, 19, 21, 33, 34, 48, 52, 56 -59, 60, 65, 68, 82, 83,84 There were 2 meeting presentations published in a journal of abstracts. 18,49 The assessment methodology in 7 studies was based on independent neurological evaluation.…”

Section: Resultsmentioning

confidence: 99%

“…Of the remaining studies, one of the largest series with a quantified assessment of tremor was reported by Young et al 84 and subsequently expanded on in further reports by Frentress et al 18 and Mojica et al 49 The 161 ET patients were assessed by independent observers pre-and postprocedure using the Fahn-Tolosa-Marin rating scale (FTMRS). The dose was 140-150 Gy, and follow-up ranged from 6 to 60 months.…”

Section: Resultsmentioning

confidence: 99%

“…Dose rate-related lesions have been described, 7,56 with lesions larger than 175 mm 3 recorded using MRI in patients treat-ed after replenishing the 60 Co sources compared with 311 mm 3 in patients treated before replenishment (p = 0.041). 59 Major changes on T2-weighted and FLAIR sequences affecting the thalamus or internal capsule medially have been related to higher complication rates; 33,34,52,65,79,83 these complications may be serious 4,18,61,65 or they may also be asymptomatic. 24,57 Young et al 84 reported a mean lesion size of 188 mm 3 on MRI after 157 GKRS procedures, with the size increasing to 871 mm 3 in patients with complications (p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Follow-up periods were highly variable. Although some articles reported good results for up to 6 or 7 years after SRS, 14,18,49,83 in general, follow-up tended to be short, which affects both the complication rate and the long-term response results.…”

Section: Discussionmentioning

confidence: 99%

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Stereotactic radiosurgery for tremor: systematic review

Martínez-Moreno

Sahgal

Salles

et al. 2019

Journal of Neurosurgery

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OBJECTIVE The aim of this systematic review is to offer an objective summary of the published literature relating to stereotactic radiosurgery (SRS) for tremor and consensus guideline recommendations. METHODS This systematic review was performed up to December 2016. Article selection was performed by searching the MEDLINE (PubMed) and EMBASE electronic bibliographic databases. The following key words were used: "radiosurgery" and "tremor" or "Parkinson's disease" or "multiple sclerosis" or "essential tremor" or "thalamotomy" or "pallidotomy." The search strategy was not limited by study design but only included key words in the English language, so at least the abstract had to be in English. RESULTS A total of 34 full-text articles were included in the analysis. Three studies were prospective studies, 1 was a retrospective comparative study, and the remaining 30 were retrospective studies. The one retrospective comparative study evaluating deep brain stimulation (DBS), radiofrequency thermocoagulation (RFT), and SRS reported similar tremor control rates, more permanent complications after DBS and RFT, more recurrence after RFT, and a longer latency period to clinical response with SRS. Similar tremor reduction rates in most of the reports were observed with SRS thalamotomy (mean 88%). Clinical complications were rare and usually not permanent (range 0%-100%, mean 17%, median 2%). Follow-up in general was too short to confirm long-term results. CONCLUSIONS SRS to the unilateral thalamic ventral intermediate nucleus, with a dose of 130-150 Gy, is a well-tolerated and effective treatment for reducing medically refractory tremor, and one that is recommended by the International Stereotactic Radiosurgery Society.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Stereotactic radiosurgery for tremor: systematic review

Martínez-Moreno

Sahgal

Salles

et al. 2019

Journal of Neurosurgery

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Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta‐analysis

et al. 2017

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Both lesioning and stimulation thalamic surgery produce adverse effects on speech. Left-sided and bilateral procedures are approximately 3-fold more likely to cause speech difficulty. This effect was higher after thalamotomy compared to DBS. In the thalamotomy group, the risk was higher in Parkinson's patients, whereas in the DBS group it was higher in patients with essential tremor. Understanding the pathophysiology of speech disturbance after thalamic procedures is a priority. © 2017 International Parkinson and Movement Disorder Society.

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Gamma Knife Radiosurgery (GKRS) in the Management of Parkinson's Disease and Essential Tremor: Long-term Follow-up Report of 192 Cases

Cited by 2 publications

References 0 publications

Stereotactic radiosurgery for tremor: systematic review

Stereotactic radiosurgery for tremor: systematic review

Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta‐analysis

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