Gamma knife radiosurgery for jugular foramen schwannomas

Zhang, Nan; Pan, Li; Dai, Jia Zhong; Wang, Bin Jiang; Wang, En Min; Cai, Pei Wu

doi:10.3171/jns.2002.97.supplement_5.0456

Cited by 44 publications

(19 citation statements)

References 5 publications

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“…They observed a 96% rate of tumor growth control and 0% rate of resultant neurological deficits over a follow-up period of more than 3 years. 45 In the current study, GKS resulted in an overall tumor control for 80.6% of our patients with nonvestibular schwannomas. Moreover, neurological preservation or improvement was demonstrated in 88% of patients.…”

Section: Stereotactic Radiosurgerysupporting

confidence: 48%

Gamma Knife surgery for nonvestibular schwannomas: radiological and clinical outcomes

Elsharkawy

Xu²,

Schlesinger³

et al. 2012

JNS

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Section: Stereotactic Radiosurgerysupporting

confidence: 48%

Gamma Knife surgery for nonvestibular schwannomas: radiological and clinical outcomes

Elsharkawy

Xu²,

Schlesinger³

et al. 2012

JNS

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“…10,16 Far fewer reports have documented the utility of stereotactic radiosurgery in nonvestibular schwannomas. 6,14,20,27,34,35,39 A search of the literature revealed only 11 cases (1 LINAC and 10 GKRS) that have received stereotactic radiation as the treatment modality for AN schwannomas. 4,6,11,14,35 35 Although an overall tumor control rate of 95% was reported at a mean follow-up of 24 months, further details regarding the outcome of patients with AN schwannomas, in particular, were not available.…”

Section: Discussionmentioning

confidence: 99%

Gamma Knife radiosurgery in the treatment of abducens nerve schwannomas: a retrospective study

Prasad¹,

Sharma²,

Kale³

et al. 2016

JNS

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OBJECTIVE Of the intracranial schwannomas, those arising from the vestibular nerves are the most common. Abducens nerve (AN) schwannomas are very rare, and there is limited literature on their optimal management. Therapeutic options include surgery and/or stereotactic radiosurgery. The aim of this study was to evaluate the role of Gamma Knife radiosurgery (GKRS) in these sixth cranial nerve (CN) schwannomas. METHODS The authors performed a retrospective analysis of patients who had undergone GKRS for intracranial tumors at their institute in the period from 2003 to 2010. Inclusion criteria were as follows: isolated AN paresis on presentation, a lesion along the course of the sixth CN, and imaging features characteristic of a schwannoma. Patients with other CN deficits and neurofibromatosis Type 2 were excluded. Symptomatic improvement was defined as the resolution of or an improvement in diplopia noted on a subjective basis or as an improvement in lateral eyeball excursion noted objectively on follow-up. A reduction in tumor volume by at least 20%, as noted by comparing the pre- and post-GKRS images, was deemed significant. RESULTS Six patients with a mean age of 37.1 years (range 17-55 years) underwent primary GKRS. There were 2 prepontine cistern, 3 cavernous sinus, and 1 cisterno-cavernous tumor. The mean duration of symptoms was 6.1 months (range 3-12 months). The mean tumor volume was 3.3 cm (range 1.5-4.8 cm). The mean tumor margin radiation dose was 12.5 Gy (range 12-14 Gy), while the median margin dose was 12 Gy (50% isodose line). The median number of isocenters used was 5 (range 4-8). The brainstem received an average 8.35-Gy radiation dosage (range 5.5-11 Gy). The mean follow-up duration was 44.3 months (range 24-78 months). Symptoms remained stable in 1 patient, improved in 3, and resolved in 2 (total improvement 83%). Magnetic resonance imaging at the last follow-up showed a stable tumor size in 3 patients (50%) and a reduction in the other 3. Thus, the tumor control rate achieved was 100%. No new CN deficits were noted. CONCLUSIONS Abducens nerve schwannomas are rare intracranial tumors. They can be cavernous, cisternal, or cisterno-cavernous in location. Excellent tumor control rates and symptomatic improvement can be achieved with GKRS, which appears to be a safe and effective, minimally invasive modality for the treatment of such lesions. Therefore, it is reasonable to consider GKRS as the initial treatment of choice for this rare pathology. Long-term follow-up will be essential for further recommendations.

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“…Radiosurgery has been shown to be an excellent alternative for the management of selected patients with intracranial schwannomas (Cokkeser et al, 2000, Zhang et al, 2002, Ramina et al, 2005b, Martin et al, 2007, Bakar, 2008, Hamm et al, 2008, Cho et al, 2009, Fukuda et al, 2009, Safavi-Abbasi et al, 2010. One patient (case 8) in this series had a previous surgery for her triple DSJFS and a gamma knife (2007) for the residual tumour elsewhere, but the residual tumour was larger than the volume limits of gamma knife and a reoperation with tumour resection was necessary.…”

Section: Radiosurgerymentioning

confidence: 92%

Triple dumbbell-shaped jugular foramen schwannomas

Wan

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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Gamma knife radiosurgery for jugular foramen schwannomas

Cited by 44 publications

References 5 publications

Gamma Knife surgery for nonvestibular schwannomas: radiological and clinical outcomes

Gamma Knife surgery for nonvestibular schwannomas: radiological and clinical outcomes

Gamma Knife radiosurgery in the treatment of abducens nerve schwannomas: a retrospective study

Triple dumbbell-shaped jugular foramen schwannomas

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