Gamma Knife radiosurgery for brain metastases from gastrointestinal primary

Page, B.R.; Wang, Edina C.; White, Lance; McTyre, E.; Peiffer, Ann M.; Alistar, Angela; Mu, Frank; Loganathan, Amritraj G.; Bourland, J. Daniel; Laxton, Adrian W.; Tatter, Stephen B.; Chan, Michael D.

doi:10.1111/1754-9485.12584

Cited by 7 publications

(17 citation statements)

References 21 publications

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“…Similar to other studies, we demonstrated that the OS is better for patients with KPS ≥ 70 from the univariate analysis (31,32). Xiaoyu et al showed that the OS increased for patients with a favourable KPS score from univariate and multivariate analyses (42).…”

Section: █ Conclusionsupporting

confidence: 90%

Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Saginc

Baltalarli²,

Sagtas³

et al. 2019

Turkish Neurosurgery

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AIM: To retrospectively evaluate the overall survival (OS) of patients with brain metastases (BMs) who had been treated with whole brain radiotherapy (WBRT) and Gamma Knife (GK) according to prognostic factors and prognostic index scores. MATERIAL and METHODS: The study included 91 patients with BMs who had been treated with WBRT and/or GK between 2014 and 2017. The patients with BMs were retrospectively evaluated regarding age, sex, Karnofsky Performance Status (KPS), recursive partitioning analysis (RPA) class, basic score for BM (BS-BM), Graded Prognostic Assessment (DS-GPA) index, primary tumour type, extracranial metastases, primary tumour control, number of BMs, and brain metastasectomy. A univariate analysis of the OS was performed using the Kaplan-Meier method, supplemented by the log-rank test. We also applied a multivariate survival analysis using the Cox regression model. RESULTS: The median OS for all patients with BMs was 6 months. Meanwhile, the median OSs for those with WBRT, GK, and WBRT-GK treatment were 6, 4, and 15 months, respectively (p=0.00). In the multivariate analysis, the female sex (p=0.030), brain metastasectomy (p=0.047), treatment with WBRT-GK (p=0.001), and the controlled primary tumour (p=0.007) significantly correlated with the OS. Furthermore, the BS-BM (p=0.022) was closely related with the OS compared to the RPA and DS-GPA in the multivariate analysis. CONCLUSION: The BS-BM was found to better predict the survival of patients with BMs according to the prognostic index scores in the multivariate analysis. Thus, our data suggest that the BS-BM is the most appropriate prognostic index.

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Section: █ Conclusionsupporting

confidence: 90%

Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Saginc

Baltalarli²,

Sagtas³

et al. 2019

Turkish Neurosurgery

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“…Several retrospective studies on SRS treatment for BMs from GI cancer have been reported. However, patient numbers in these reports were relatively small [1,2,4,5].…”

Section: Introductionmentioning

confidence: 94%

“…Gastrointestinal (GI) cancer rarely metastasizes to the brain. Particularly, brain metastases (BMs) from esophageal and gastric cancers are much less common than colorectal cancer BMs [1][2][3][4][5]. However, due to the currently widespread use of magnetic resonance (MR) imaging with gadolinium enhancement, BMs are being detected ever more frequently.…”

Section: Introductionmentioning

confidence: 99%

“…However, due to the currently widespread use of magnetic resonance (MR) imaging with gadolinium enhancement, BMs are being detected ever more frequently. Even in recently published studies, the outcomes of patients with GI cancer BMs were poor, i.e., median survival times (MST) from diagnosis of BMs were reportedly 6 months or slightly more [1,2,4,5]. A general consensus regarding the optimal treatment is, however, currently lacking, i.e., there are no specific recommendations for treating BMs from GI cancers.…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, brain metastases (BMs) from esophageal and gastric cancers are much less common than colorectal cancer BMs. 1 , 2 , 3 , 4 , 5 However, due to the currently widespread use of magnetic resonance (MR) imaging with gadolinium enhancement, BMs are being detected ever more frequently. Even in recently published studies, the outcomes of patients with GI cancer BMs were poor, that is, median survival times (MSTs) from diagnosis of BMs were reportedly 6 months or slightly more.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stereotactic Radiosurgery Results for Patients With Brain Metastases From Gastrointestinal Cancer: A Retrospective Cohort Study of 802 Patients With GI-GPA Validity Test

Yamamoto¹,

Serizawa²,

Sato³

et al. 2021

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Cerebral metastases

Ganz

2022

Progress in Brain Research

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Gamma Knife radiosurgery for brain metastases from gastrointestinal primary

Abstract: Colorectal cancer metastases tend to have a higher rate of leptomeningeal failure than other types of GI cancer metastases. Radiosurgical management of brain metastases from GI primary represents an acceptable management option. Neurologic death remains problematic.

Cited by 7 publications

References 21 publications

Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Analysis of survival of patients with brain metastases according to prognostic indexes and treatment strategies

Stereotactic Radiosurgery Results for Patients With Brain Metastases From Gastrointestinal Cancer: A Retrospective Cohort Study of 802 Patients With GI-GPA Validity Test

Cerebral metastases

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