Gamma-irradiation applied in the synthesis of metallic and organic nanoparticles: A short review

Flores-Rojas, Guadalupe G.; López‐Saucedo, Felipe; Bucio, Emilio

doi:10.1016/j.radphyschem.2018.08.011

Cited by 112 publications

(51 citation statements)

References 176 publications

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“…On another hand, the spectra of NDMX‐Ag and NDEX‐Ag films showed a significant shift in their bands in a similar way to the films loaded with CuNPs. The band in 3400 cm −1 is attributed to hydroxyl and amino groups indicated the interaction with the AgNPs, as well as the band assigned to carbonyl group at 1660 cm −1 due to a decrease of the intensity, being this marked for the band assigned to amine groups which is in accordance to previous reports 47 . In addition, the bands of N‐H at 1457 and 1458 cm −1 , and C‐O at 1376 and 1379 cm −1 were displaced too.…”

Section: Resultssupporting

confidence: 92%

Improving thermo‐responsive hydrogel films by gamma rays and loading of Cu and Ag nanoparticles

López-Barriguete

Flores-Rojas

López‐Saucedo

et al. 2020

J of Applied Polymer Sci

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This paper presents two modified copolymeric hydrogel films with thermo‐responsiveness. The final films are hydrogels containing N‐isopropylacrylamide, N‐N‐dimethylacrylamide, methyl methacrylate, and ethoxyethyl methacrylate. The incorporation of Ag and Cu in the smart hydrogel films endowed them with specific properties that could be useful in developing biological sensors, smart membranes, or flexible electronic components, which are proper for design and improvement on technology and biomedical applications. The films were synthesized in solution by gamma radiation at a dose rate of 10 kGy h−1, and an absorbed dose of 50 kGy. The characterization was realized by different spectroscopic and microscopic techniques as FTIR‐ATR, atomic force microscopy, SEM–EDX, TGA, and DSC. The hydrogel films were grafted with glycidyl methacrylate showing high resistance, biocompatibility, adequate adaptability, flexibility, in addition to the capacity of metal doping with silver and copper.

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Section: Resultssupporting

confidence: 92%

Improving thermo‐responsive hydrogel films by gamma rays and loading of Cu and Ag nanoparticles

López-Barriguete

Flores-Rojas

López‐Saucedo

et al. 2020

J of Applied Polymer Sci

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“…Polymers containing functional groups (PEG-diamine) were acting as stabilizers and capping agents due to their high affinity for Pt. These polymers anchor on the surface of NPs and provide electrostatic repulsion and steric hindrance [47]. Moreover, polymers played an important role in formation of NFs.…”

Section: Synthesis and Characterization Of Pt Nfsmentioning

confidence: 99%

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

Yang

Salado-Leza

Porcel

et al. 2020

IJMS

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Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. In this study, we used this method to prepare biocompatible PEGylated (with Poly(Ethylene Glycol) diamine) platinum nanoflowers (Pt NFs). These nanoagents provide unique surface chemistry, which allows functionalization with various molecules such as fluorescent markers, drugs or radionuclides. The Pt NFs were produced with a controlled aggregation of small Pt subunits through a combination of grafted polymers and radiation-induced polymer cross-linking. Confocal microscopy and fluorescence lifetime imaging microscopy revealed that Pt NFs were localized in the cytoplasm of cervical cancer cells (HeLa) but not in the nucleus. Clonogenic assays revealed that Pt NFs amplify the gamma rays induced killing of HeLa cells with a sensitizing enhancement ratio (SER) of 23%, thus making them promising candidates for future cancer radiation therapy. Furthermore, the efficiency of Pt NFs to induce nanoscopic biomolecular damage by interacting with gamma rays, was evaluated using plasmids as molecular probe. These findings show that the Pt NFs are efficient nano-radio-enhancers. Finally, these NFs could be used to improve not only the performances of radiation therapy treatments but also drug delivery and/or diagnosis when functionalized with various molecules.

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“…Different techniques have Fig. 1 Schematic representation of the top-down (images with the green background) and bottom-up (images with pale yellow background) approaches of nanoparticle synthesis, the image was adapted and redrawn from [52][53][54][55][56][57][58][59][60] been developed in order to overcome these constraints, including shaker mills, tumbler mills, vibratory mills, attrition mills and planetary mills.…”

Section: Millingmentioning

confidence: 99%

Current Strategies for Noble Metal Nanoparticle Synthesis

2021

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Noble metals have played an integral part in human history for centuries; however, their integration with recent advances in nanotechnology and material sciences have provided new research opportunities in both academia and industry, which has resulted in a new array of advanced applications, including medical ones. Noble metal nanoparticles (NMNPs) have been of great importance in the field of biomedicine over the past few decades due to their importance in personalized healthcare and diagnostics. In particular, platinum, gold and silver nanoparticles have achieved the most dominant spot in the list, thanks to a very diverse range of industrial applications, including biomedical ones such as antimicrobial and antiviral agents, diagnostics, drug carriers and imaging probes. In particular, their superior resistance to extreme conditions of corrosion and oxidation is highly appreciated. Notably, in the past two decades there has been a tremendous advancement in the development of new strategies of more cost-effective and robust NMNP synthesis methods that provide materials with highly tunable physicochemical, optical and thermal properties, and biochemical functionalities. As a result, new advanced hybrid NMNPs with polymer, graphene, carbon nanotubes, quantum dots and core–shell systems have been developed with even more enhanced physicochemical characteristics that has led to exceptional diagnostic and therapeutic applications. In this review, we aim to summarize current advances in the synthesis of NMNPs (Au, Ag and Pt).

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Gamma-irradiation applied in the synthesis of metallic and organic nanoparticles: A short review

Cited by 112 publications

References 176 publications

Improving thermo‐responsive hydrogel films by gamma rays and loading of Cu and Ag nanoparticles

Improving thermo‐responsive hydrogel films by gamma rays and loading of Cu and Ag nanoparticles

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

Current Strategies for Noble Metal Nanoparticle Synthesis

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