Gamma-Glutamyltransferase, Atherosclerosis, and Cardiovascular Disease

Emdin, Michele; Pompella, Alfonso; Paolicchi, Aldo

doi:10.1161/circulationaha.105.571919

Cited by 299 publications

(287 citation statements)

References 21 publications

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“…1 Several studies demonstrated that an increase in serum GGT activity can be used as a marker for increased oxidative stress in humans. 2,10 It has been shown that GGT activity is directly related to the oxidative events, and plays an important role in the evolution of atheromatous plaque. 2,3,1 -14…”

Section: Ggt Activity and Oxidative Stressmentioning

confidence: 99%

“…It has been reported that degradation of GSH may play a prooxidant role in selected conditions; low density lipoprotein (LDL) oxidation through GSH/GGT-dependent iron reduction has been suggested as an important mechanism in the pathogenesis of atherosclerosis. 2 It has been shown that GGT activity is present in atherosclerotic coronary plaques. 3 Increased GGT activity has been found to be associated with the development of hypertension and type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

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The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

Demircan

Yazıcı

Durna

et al. 2009

Clinical Cardiology

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Background: In this study, we sought to investigate the relation of gamma-glutamyltransferase (GGT) levels with the significance of coronary artery disease (CAD), clinical presentation, left ventricular (LV) function, and inflammatory activity. Methods: A total of 235 patients (mean age: 60.1 ± 10.5 years, 166 [70%] males) who had coronary angiography were included in the study. Patients who had CAD constituted the study group (Group 1, n = 189) and patients who had insignificant coronary disease or normal coronary activity constituted the control group (Group 2, n = 46). Results: GGT levels were higher in Group 1 than Group 2 (38.7 ± 30.9 U/L versus 27.5 ± 17.5 U/L, p = 0.025). Left ventricular ejection fraction (LVEF) was lower in Group 1 than Group 2 (52.6%±11.7% versus 58.8%±11.3%, p<0.002). GGT activity (40.2 ± 32.5 U/L versus 29.1 ± 18.3 U/L, p<0.002) and c-reactive protein (CRP) levels (33.9 ± 43.6 mg/dl versus 17.8 ± 29.8 mg/dl, p<0.002) were higher, LVEF (52.6%±12.1% versus 56.5%±11.0%, p = 0.021) was lower in patients with acute coronary syndrome compared with stable CAD group. In regression analysis, CRP levels (p<0.0001, odds ratio [OR] = 3.77, 95% confidence interval [CI] 0.10

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Section: Ggt Activity and Oxidative Stressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

Demircan

Yazıcı

Durna

et al. 2009

Clinical Cardiology

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“…Some researchers interpreted that serum GGT predicts type 2 diabetes because it acts as a pro-oxidant or a marker of hepatic steatosis [12][13][14]. These mechanisms may partly explain some of the associations between GGT and type 2 diabetes, especially those observed at relatively high levels of serum GGT activity.…”

mentioning

confidence: 99%

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes?

2007

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The results of several epidemiological studies of serum γ-glutamyltransferase (GGT) led us to hypothesise that associations of GGT within its normal range with type 2 diabetes may reflect detrimental effects of xenobiotics found in the environment, such as persistent organic pollutants (POPs). Epidemiological observations showed that serum GGT activity within its normal range strongly predicted future type 2 diabetes; the predictability of diabetes from obesity was low with GGT at the low end of the normal range; and GGT showed a positive association with known markers of oxidative stress or inflammation. Experimental findings on cellular GGT suggest that serum GGT levels within the normal range may reflect oxidative stress related to the re-synthesis of intracellular glutathione; however, this interpretation is not completely satisfying because, in its role of regenerating intracellular glutathione, GGT activity should be antioxidative.

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“…Although g-GT activity has been considered to be an index of hepatobiliary dysfunction and alcohol abuse, recent epidemiological and pathological studies have suggested its independent role in the pathogenesis and clinical evolution of cardiovascular disease. 16,17 The prospective study by Ruttmann 18 of 163 944 Austrian adults studied for 17 years shows that g-GT is independently associated with cardiovascular mortality independent of all confounders, including liver function and alcohol use. This has been confirmed in both unselected populations and patients with ascertained coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results

Munakata

Honma²,

Akasi³

et al. 2011

Hypertens Res

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on behalf of the J-STOP-MetS Study GroupThe aim of this study was to examine whether additional repeated counselling further improves the health effects of limited, highly individualized lifestyle guidance in metabolic syndrome. One hundred and nine previously untreated metabolic syndrome patients received highly standardized and individualized lifestyle guidance for weight loss. A tentative goal of 5% weight reduction over the course of 2 months was set. Patients were then randomly assigned to either the multiple guidance group who received further counselling every 2 months (n¼52) or the single guidance group who received no further guidance until the final assessment 6 months later (n¼57). Baseline data between the multiple guidance and single guidance groups were similar. Body weight and waist circumference were significantly reduced, and liver function, lipid profiles and glucose metabolism were significantly improved in both groups. After adjustment for baseline data, the multiple guidance group showed considerably higher reduction in waist circumference and fasting blood sugar concentration than the single guidance group. These data suggest that additional counselling further improved the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome.

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Gamma-Glutamyltransferase, Atherosclerosis, and Cardiovascular Disease

Cited by 299 publications

References 21 publications

The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

Can persistent organic pollutants explain the association between serum γ-glutamyltransferase and type 2 diabetes?

Repeated counselling improves the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome: J-STOP-METS final results

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