Gamma‐glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer

Wang, He; Guo, Guifang; Yin, Chenxi; Jiang, Chang; Wang, F.; Qiu, Hai Bo; Chen, X.-x.; Rong, Ruming; Zhang, B.; Xia, Liangping

doi:10.1111/codi.12258

Cited by 31 publications

(28 citation statements)

References 32 publications

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“…In clinical practices, liver functions have long been considered to assume crucial status in the prognosis of many types of cancers such as gallbladder and colorectal cancers 12,19,20. Liver functions can be reflected by markers not only like ALB, GELO, and TP, indicators of the nutritional status, but also like ALP, ALT, AST, GGT, LDH, TBIL, and DBIL, indices reflecting liver damage.…”

Section: Discussionmentioning

confidence: 99%

Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma

Zhang¹,

Ning²,

Xu³

et al. 2017

OTT

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ObjectiveLiver functions, reflective of the overall status of the host, have been reported to be important factors affecting the prognosis in many types of cancers. In this study, we explored the influences of liver enzymes albumin (ALB), globulin (GELO), total protein (TP), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), gamma glutamyltranspeptidase (GGT), and lactate dehydrogenase (LDH) on the overall survival (OS) in a number of 173 patients with intrahepatic cholangiocarcinoma (ICC).Patients and methodsBetween 2011 and 2015, we enrolled patients with pathologically proven locally advanced or metastatic ICC. The impact of ALB, GELO, TP, ALP, ALT, AST, TBIL, DBIL, GGT, and LDH on OS were analyzed using Kaplan–Meier analysis. Next, the associations between these liver enzymes and OS were evaluated by univariate and multivariate analyses. Finally, the role of these enzymes in OS was evaluated in the subgroups.ResultsElevated liver enzymes were linked with OS. We revealed that independent prognostic factors of poor outcome were ALP, TBIL, DBIL, and GGT, whereas ALB is a protective factor in ICC patients.ConclusionOur results demonstrate that these liver enzymes may serve as valuable predictive markers in ICC patients.

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Section: Discussionmentioning

confidence: 99%

Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma

Zhang¹,

Ning²,

Xu³

et al. 2017

OTT

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“…LDH has also been incorporated in prognostic scores for several types of cancer11. However, the consistency and magnitude of the prognostic impact of LDH are unclear121314. The aim of this study was to review published studies and use standard meta-analytic techniques to quantify the prognostic value of LDH in various solid tumors.…”

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confidence: 99%

Prognostic value of pretreatment serum lactate dehydrogenase level in patients with solid tumors: a systematic review and meta-analysis

Zhang

Yao

et al. 2015

Sci Rep

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Although most studies have reported that high serum lactate dehydrogenase (LDH) levels are associated with poor prognosis in several malignancies, the consistency and magnitude of the impact of LDH are unclear. We conducted the first comprehensive meta-analysis of the prognostic relevance of LDH in solid tumors. Overall survival (OS) was the primary outcome; progression-free survival (PFS) and disease-free survival (DFS) were secondary outcomes. We identified a total of 68 eligible studies that included 31,857 patients. High LDH was associated with a HR for OS of 1.48 (95% CI = 1.43 to 1.53; P < 0.00001; I2 = 93%), an effect observed in all disease subgroups, sites, stages and cutoff of LDH. HRs for PFS and DFS were 1.70 (95% CI = 1.44 to 2.01; P < 0.00001; I2 = 13%) and 1.86(95% CI = 1.15 to 3.01; P = 0.01; I2 = 88%), respectively. Analysis of LDH as a continuous variable showed poorer OS with increasing LDH (HR 2.11; 95% CI = 1.35 to 3.28). Sensitivity analyses showed there was no association between LDH cutoff and reported HR for OS. High LDH is associated with an adverse prognosis in many solid tumors and its additional prognostic and predictive value for clinical decision-making warrants further investigation.

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“…In addition, ALP has also been included in the Chinese University Prognostic Index, an liver cancer staging system that assigns a score of 3 when ALP is >200 IU/L (Leung et al, 2002). On the other hand, GGT was also recognized as a novel adverse prognostic marker in renal cancer, colorectal cancer, esophageal cancer, liver cancer and cholangiocarcinoma (He et al, 2013;Hofbauer et al, 2014;Ma et al, 2014;Yang et al, 2014). These previous studies strongly indicated the valuable prognostic roles of ALP and GGT in malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

Xu¹,

Miao²,

Zhang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Gamma‐glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer

Abstract: Among GGT, LDH and ALP, only GGT plays an independent role with CEA in predicting OS and PFS in mCRC. When coupled with CEA, GGT may lead to improved prognostic predictors.

Cited by 31 publications

References 32 publications

Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma

Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma

Prognostic value of pretreatment serum lactate dehydrogenase level in patients with solid tumors: a systematic review and meta-analysis

Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

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