1994
DOI: 10.1165/ajrcmb.11.5.7946387
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gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.

Abstract: The tripeptide glutathione (GSH) is used by cells to detoxify hydroperoxides, produced during oxidative stress, and is consumed in the process. Previous studies have indicated that cells can be protected against oxidative stress by extracellular GSH through its degradation catalyzed by the exoenzyme gamma-glutamyl transpeptidase (gamma GT) and its de novo synthesis within the cytosol. We hypothesized that gamma GT would be increased as part of the adaptation of cells to oxidative stress. We examined whether ox… Show more

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Cited by 154 publications
(112 citation statements)
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“…The data also suggest that HNE could induce GGT mRNA V expression via this EpRE. Based on the evidence that GGT mRNA V-2 is abundant in the lung and that the induction of mRNA V-2 is through EpRE, it can be inferred that EpRE/Nrf2 signaling is at least partially involved in GGT induction by other oxidative stress generators, including the redox-cycling quinones [11][12][13][14], NO 2 [10], and hyperoxia [15]. Because every investigated type of oxidative stress results in increased HNE production [41,88], the underlying mechanism of GGT induction by these agents likely involves the production of the common inducer HNE.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The data also suggest that HNE could induce GGT mRNA V expression via this EpRE. Based on the evidence that GGT mRNA V-2 is abundant in the lung and that the induction of mRNA V-2 is through EpRE, it can be inferred that EpRE/Nrf2 signaling is at least partially involved in GGT induction by other oxidative stress generators, including the redox-cycling quinones [11][12][13][14], NO 2 [10], and hyperoxia [15]. Because every investigated type of oxidative stress results in increased HNE production [41,88], the underlying mechanism of GGT induction by these agents likely involves the production of the common inducer HNE.…”
Section: Discussionmentioning
confidence: 99%
“…These substances include aflatoxin B1 [9], NO 2 [10], redox cycling quinones [11][12][13][14], and hyperoxia [15]. Induction of GGT by oxidative stress facilitates GSH turnover, de novo GSH synthesis, and the metabolism and detoxification of GSH conjugates and therefore is an important adaptive response that protects cells from oxidative and xenobiotic injury.…”
Section: Introductionmentioning
confidence: 99%
“…c-GT expression is increased in rat lung epithelial cells by oxidants such as menadione and tbutyl hydroquinone [118], suggesting that c-GT might play a role in protection against oxidative stress. However, cigarette smoke condensate and oxidative stress had no effect on c-GT activity in a human type II alveolar epithelial cell lines (A549 cells) [71].…”
Section: Role Of C-glutamyl Transpeptidase In the Regulation Of Glutamentioning
confidence: 99%
“…GGT activity is typically increased by oxidative stress [64]: very young children with CF but without inflammation can have normal GSH levels, perhaps due to alternative, developmentally regulated mechanisms for GSH transport that are lost with age [58].…”
Section: Antioxidants In the Airway Lumen Mucinmentioning
confidence: 99%