Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of type 2 diabetes mellitus incidence

Xie, Wangcheng; Liu, Bin; Tang, Yun; Yang, Tingsong; Song, Zhenshun

doi:10.3389/fendo.2022.1026791

Cited by 5 publications

(12 citation statements)

References 39 publications

(56 reference statements)

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“…While the role of GGT/HDL-C ratio in MetS resolution is novel, existing studies support its utility as a predictor of cardiometabolic diseases. 17 Chinese studies have linked elevated GGT/HDL-C ratios with an increased risk of T2DM and found its predictive performance for T2DM superior to that of GGT and HDL-C individually. 17 , 18 Furthermore, a one-unit increase in the GGT/HDL-C ratio corresponded to a 0.4% and 0.5% increase in the prevalence of NAFLD and MetS, respectively.…”

Section: Discussionmentioning

confidence: 99%

Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy

Lizarbe-Lezama,

Rodriguez-Macedo,

Fernandez-Guzman

et al. 2024

Diabetes and Vascular Disease Research

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Objective To evaluate the association between GGT/HDL-C ratio and resolution of MetS in adults after sleeve gastrectomy (SG). Methods We conducted a retrospective cohort study using secondary data from a Peruvian bariatric center. The study population consisted of adults aged 18 and above who underwent laparoscopic SG and were diagnosed with MetS prior to the surgery. The main outcome measured was MetS resolution 6 months post-surgery and the exposure variable was the GGT/HDL-C ratio. Results We analyzed 137 patients with a mean age of 38.9 ± 10.9 years; 64.2% were females. The median GGT/HDL-C ratio was 1.1 [0.7 – 1.5], and 83.9% of patients experienced resolution of MetS. Furthermore, both the middle tertile of GGT/HDL-C (aRR: 1.28; 95% CI: 1.04 - 1.58; p = .019) and the lowest tertile (aRR: 1.27; 95% CI: 1.01 - 1.60; p = .038) showed a significant association with the resolution of MetS. Conclusion Eight out of 10 patients undergoing SG experience resolution of MetS within 6 months after surgery. Patients in the middle and lower tertiles of the GGT/HDL-C were more likely to achieve this outcome. Therefore, the GGT/HDL-C ratio should be considered a valuable and efficient biomarker for preoperative assessment of bariatric surgery candidates.

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Section: Discussionmentioning

confidence: 99%

Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy

Lizarbe-Lezama,

Rodriguez-Macedo,

Fernandez-Guzman

et al. 2024

Diabetes and Vascular Disease Research

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“…Some investigators suggest that elevated serum GGT reflects oxidative stress and chronic inflammation, which also contributes to the development of MetS ( 45 , 46 ). GGT not only positively correlates with numerous inflammatory factors such as C-reactive protein and interleukin-6, but also itself mediates the conversion of leukotriene C4 to leukotriene D4, which enhances the development of inflammation ( 15 ). Numerous previous studies have demonstrated that GGT is a useful biomarker for predicting MetS and its components, and that the risk of MetS increases with increasing levels of GGT ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…Dyslipidemia is a risk factor for MetS, and reduced HDL-C is the most common clinical disorder of lipid metabolism. As part of the diagnosis of MetS, HDL-C can improve cellular uptake of glucose in skeletal muscle cells and insulin secretion from beta cells and helps protect β-cells from apoptosis caused by cholesterol accumulation by promoting cholesterol efflux ( 15 , 16 ). HDL-C also has anti-inflammatory and antioxidant effects, directly increasing beta cell survival by inhibiting apoptosis caused by oxidized LDL-C and inflammatory factors, HDL-C decreased levels may reflect reduced beta cell function and insulin resistance ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…The GGT/HDL-C ratio, a new metric proposed in a recent study, is not only less susceptible to interference, but is also readily available and has been shown to be a good predictor of risk for T2DM, non-alcoholic fatty liver disease (NAFLD) and is strongly associated with IR ( 15 – 17 ). Liver is one of the main target organs for insulin and liver dysfunction is closely associated with the development of MetS ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio is a more powerful marker than TyG index for predicting metabolic syndrome in patients with type 2 diabetes mellitus

Gong,

Gan,

Zhang

et al. 2023

Front. Endocrinol.

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PurposeThe prevalence of metabolic syndrome (MetS) is increasing globally and has become a global and national public health problem that cannot be ignored as an independent predictor of cardiovascular events, cancer and all-cause mortality. γ-glutamyl transferase (GGT) and high-density lipoprotein cholesterol (HDL-C) are associated with insulin resistance, dyslipidemia and oxidative stress. This study was designed to explore the relationship and predictive performance between γ-glutamyl transferase high-density lipoprotein cholesterol ratio (GGT/HDL-C) and MetS.MethodsThis was a cross-sectional study. MetS was diagnosed from biochemical and anthropometric data in subjects with T2DM. Multivariate logistic regression was used to analyses the relationship between GGT/HDL-C ratio, TyG index and HOMA-IR and MetS in subjects with T2DM. Receiver operating characteristic (ROC) curve was drawn and the areas under the curve (AUC) were used to assess the ability of these indexes in screening MetS in subjects with T2DM. Statistical differences between the AUC values of these indexes were compared. In addition, we performed subgroup analyses and interactions.Results769 (70.55%) patients with T2DM were defined as having MetS. patients with MetS had higher anthropometric values and biochemical indicators compared to those without MetS. Multivariate logistic regression analysis of GGT/HDL-C ratio was an independent risk factor for MetS (Per 1 SD increase, OR = 2.49, 95% CI: 1.51, 4.10). According to ROC curve analysis, the value of GGT/HDL-C ratio in predicting MetS in subjects with T2DM was superior to that of TyG index and HOMA-IR. The best cut-off value for GGT/HDL-C prediction was 19.94.ConclusionsGGT/HDL-C ratio may be an important predictor of MetS in subjects with T2DM, and its predictive power is stronger than that of TyG index and HOMA-IR. The risk of MetS in subjects with T2DM is increased in the presence of a higher GGT/HDL-C ratio.

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“…Several recent studies have shown that combining GGT with HDL-C can improve the identification of nonalcoholic fatty liver disease (NAFLD) ( 13 – 15 ) and type 2 diabetes mellitus (T2DM) ( 16 – 18 ). The GGT/HDL-C ratio was found to be closely linked to NAFLD and T2DM and was a better predictor than a single indicator.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific associations of γ-glutamyltransferase to HDL-cholesterol ratio and the incident risk of cardiovascular disease: three Korean longitudinal cohorts from different regions

et al. 2023

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BackgroundThe combination of gamma-glutamyl transferase (GGT) and high-density lipoprotein cholesterol (HDL-C) (GGT/HDL-C) is a novel noninsulin-based marker for assessing the risk of nonalcoholic fatty liver disease and type 2 diabetes mellitus. However, whether the GGT/HDL-C ratio is related to the risk of incident cardiovascular disease (CVD) risk is not well known. Therefore, we aimed to investigate the longitudinal effect of GGT/HDL-C ratio on incident CVD risk in three large cohorts of Korean men and women.MethodsData were assessed from 27,643 participants without CVD from the Korean Genome and Epidemiology Study (KoGES), Health Risk Assessment Study (HERAS), and Korea Health Insurance Review and Assessment (HIRA) (HERAS-HIRA) datasets. The participants were divided into four groups according to the GGT/HDL-C quartiles. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD using multivariate Cox proportional-hazard regression models over a 50-month period following the baseline survey.ResultsDuring the follow-up period, 949 patients (3.4%; 529 men and 420 women) developed CVD. The HRs of CVD for GGT/HDL-C quartiles 2-4 were 1.36 (95% CI, 0.91–2.02), 1.54 (95% CI, 1.05–2.26), and 1.66 (95% CI, 1.12–2.47) after adjusting for metabolic parameters in women, but GGT/HDL-C did not show a trend toward increases in incident CVD in men. Regional discrepancies were evident in the results; the increase in HR in the metropolitan hospital cohort was more pronounced than that in the urban cohort, and the risk was not increased in the rural cohort.ConclusionGGT/HDL-C ratio may be a useful predictive marker for CVD in women. Furthermore, the prevalence of CVD was strongly correlated with the GGT/HDL-C ratio in metropolitan areas, and this correlation was more significant than that observed with GGT or HDL-C in isolation.

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Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of type 2 diabetes mellitus incidence

Cited by 5 publications

References 39 publications

Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy

Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio is a more powerful marker than TyG index for predicting metabolic syndrome in patients with type 2 diabetes mellitus

Sex-specific associations of γ-glutamyltransferase to HDL-cholesterol ratio and the incident risk of cardiovascular disease: three Korean longitudinal cohorts from different regions

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