Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients

Gözükara, Mehmet Yavuz; Börekçi, Abdürrezzak; Gür, Mustafa; Aksoy, Nurten; Şeker, Taner; Kaypaklı, Onur; Uçar, Hakan; Türkoğlu, Caner; Koç, Mevlüt; Makça, İlyas; Akyol, Selahattin; Selek, Sahabettın; Çaylı, Murat

doi:10.1002/jcla.21785

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“…GGT, which is reported to be associated with the pathophysiologic process of atherosclerosis and oxidative stress, 23) was elevated in the early TTFC group. Therefore, higher GGT levels in the early TTFC group compared with the late TTFC group might indicate oxidative stress.…”

Section: Discussionmentioning

confidence: 86%

Time to First Cigarette and Hypertension in Korean Male Smokers

et al. 2015

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BackgroundMorning blood pressure surge affects to cardiovascular disease risk. Short time to first cigarette (TTFC) after waking can enhance morning blood pressure surge, and accelerate atherosclerosisMethodsWe investigated that the relationship between TTFC and blood pressure. The study subjects included male current smokers (n=211) who had health check-up in Hallym University Sacred Heart Hospital from July to September, 2014. We categorized the subjects into 2 groups according to TTFC; early TTFC (TTFC <30 minutes) and late TTFC (TTFC ≥30 minutes), and the subjects who were taking antihypertensive medications or had a high blood pressure (>140 mm Hg or 90 mm Hg) were defined as hypertensive group. Multivariate logistic regression was performed to estimate the odds ratio and 95% confidence interval to investigate the association between TTFC and hypertensive group.ResultsCompared with late TTFC, early TTFC had higher odds (odds ratio [OR], 3.87; 95% confidence interval [CI], 1.89-7.94) for hypertensive group. After adjusting confounding factors, early TTFC was significantly associated with an increased risk of hypertension (OR, 4.43; 95% CI, 1.84-10.70).Conclusionearly TTFC after waking is associated with hypertension. It suggests delaying TTFC might help to control of blood pressure among the current smokers who are not ready to immediately quit smoking.

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Section: Discussionmentioning

confidence: 86%