Gamma Entrainment Improves Synchronization Deficits in Dementia Patients

Gamma entrainment has been shown to enhance beta amyloid (Aβ) uptake in mouse models of Alzheimer's disease (AD) as well as improve cognitive symptoms of dementia in both humans and mice. Similar improvements have been reported for both invasive and non-invasive brain stimulation in the gamma oscillatory band, with 40 Hz auditory and visual sensory stimulants employed in non-invasive approaches. Non-invasive stimulation techniques possess the clear advantage of not requiring surgical procedures and can hence be applicable to a wider set of patients. The dataset introduced here was acquired with the aim of examining the network-level mechanisms governing the production of the brain's oscillatory activity during non-invasive auditory gamma-band stimulation, and thereby helping to explain the reported therapeutic effects of entrainment in AD patients. Thirteen elderly participants with memory complaints whose conditions were diagnosed as normal aging (non-AD) or mild AD based on the standard criteria for the diagnosis of AD including the mini-mental state exam (MMSE) took part in data collection in which EEG signals were recorded during auditory stimulation of the brain. The data collection session consisted of an initial one-minute rest followed by an alternating set of six stimulation trials interleaved with five rest trials. During each stimulation trial, an auditory stimulant in the form of a 40 Hz chirp was presented to the participant. The collected data from all participants were preprocessed following the full pipeline of Makoto with the use of EEGLAB and posted as a dataset named: Auditory Gamma Entrainment at OpenNeuro repository. The data record for each participant includes the EEG signal represented in standard BIDS format for one-minute rest followed by the auditory task data. A copy of the source EEG data is also provided in .txt format. The dataset can be used to study the characteristics of brain oscillations during entrainment, as well as for studies on auditory perception, analysis of resting state potentials in dementia patients, comparison of auditory evoked potentials with resting state potentials, ERP, ERSP, and SSAVP analysis of auditory response in dementia patients, time series analysis of the stimulation and rest trials, and brain connectivity analysis in dementia patients.

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Auditory gamma-band entrainment enhances default mode network connectivity in dementia patients

Lahijanian,

Aghajan,

Vahabi

2024

Sci Rep

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Dementia, and in particular Alzheimer’s disease (AD), can be characterized by disrupted functional connectivity in the brain caused by beta-amyloid deposition in neural links. Non-pharmaceutical treatments for dementia have recently explored interventions involving the stimulation of neuronal populations in the gamma band. These interventions aim to restore brain network functionality by synchronizing rhythmic energy through various stimulation modalities. Entrainment, a newly proposed non-invasive sensory stimulation method, has shown promise in improving cognitive functions in dementia patients. This study investigates the effectiveness of entrainment in terms of promoting neural synchrony and spatial connectivity across the cortex. EEG signals were recorded during a 40 Hz auditory entrainment session conducted with a group of elderly participants with dementia. Phase locking value (PLV) between different intraregional and interregional sites was examined as an attribute of network synchronization, and connectivity of local and distant links were compared during the stimulation and rest trials. Our findings demonstrate enhanced neural synchrony between the frontal and parietal regions, which are key components of the brain’s default mode network (DMN). The DMN operation is known to be impacted by dementia’s progression, leading to reduced functional connectivity across the parieto-frontal pathways. Notably, entrainment alone significantly improves synchrony between these DMN components, suggesting its potential for restoring functional connectivity.

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Gamma Entrainment Improves Synchronization Deficits in Dementia Patients

Cited by 3 publications

References 67 publications

Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer’s disease

Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer’s disease

Non-invasive auditory brain stimulation for gamma-band entrainment in dementia patients: An EEG dataset

Auditory gamma-band entrainment enhances default mode network connectivity in dementia patients

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