Gamma-delta T cell expansion is closely associated with cytomegalovirus infection in all solid organ transplant recipients

Couzi, Lionel; Lafarge, Xavier; Pitard, Vincent; Néau-Cransac, Martine; Dromer, C.; Billes, Marc-Alain; Lacaille, Florence; Moreau, Jean-François; Merville, Pierre; Déchanet‐Merville, Julie

doi:10.1111/j.1432-2277.2010.01181.x

Cited by 23 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This subset, which represents 0.5% on average of the T cell pool in CMV-seronegative patients, reaches an average of 5–10% of the circulating T cell pool in CMV-seropositive patients, and up to 50% in some patients. This phenomenon is not exclusive to the kidney transplant scenario as Vδ2 neg γδ T cell peripheral blood expansion after CMV infection has been shown in other solid-organ transplantations ( 54 – 56 ), in recipients of hematopoietic stem cell transplantation ( 57 – 59 ), in immunodeficient children ( 60 , 61 ), in neonates ( 62 ), in pregnant women ( 63 ), and in healthy individuals ( 64 ). CMV-specific CD4+ and CD8+ αβ T cells on their own already represent around 5% of the T cell pool in CMV-seropositive healthy individuals ( 65 ) and accumulate in older people ( 66 ).…”

Section: Localization Of Vδ2 Neg γδ T Cellsmentioning

confidence: 96%

Direct and Indirect Effects of Cytomegalovirus-Induced Î³Î´ T Cells after Kidney Transplantation

et al. 2015

Self Cite

View full text Add to dashboard Cite

Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2neg γδ T cells) has been characterized during the anti-CMV immune response in all solid-organ and bone-marrow transplant recipients, neonates, and healthy people. These CMV-induced Vδ2neg γδ T cells undergo a dramatic and stable expansion after CMV infection, in a conventional “adaptive” manner. Similarly, as CMV-specific CD8+ αβ T cells, they exhibit an effector/memory TEMRA phenotype and cytotoxic effector functions. Activation of Vδ2neg γδ T cells by CMV-infected cells involves the γδ T cell receptor (TCR) and still ill-defined co-stimulatory molecules such as LFA-1. A multiple of Vδ2neg γδ TCR ligands are apparently recognized on CMV-infected cells, the first one identified being the major histocompatibility complex-related molecule endothelial protein C receptor. A singularity of CMV-induced Vδ2neg γδ T cells is to acquire CD16 expression and to exert an antibody-dependent cell-mediated inhibition on CMV replication, which is controlled by a specific cytokine microenvironment. Beyond the well-demonstrated direct anti-CMV effect of Vδ2neg γδ T cells, unexpected indirect effects of these cells have been also observed in the context of kidney transplantation. CMV-induced Vδ2neg γδ T cells have been involved in surveillance of malignancy subsequent to long-term immunosuppression. Moreover, CMV-induced CD16+ γδ T cells are cell effectors of antibody-mediated rejection of kidney transplants, and represent a new physiopathological contribution to the well-known association between CMV infection and poor graft survival. All these basic and clinical studies paved the road to the development of a future γδ T cell-based immunotherapy. In the meantime, γδ T cell monitoring should prove a valuable immunological biomarker in the management of CMV infection.

show abstract

Section: Localization Of Vδ2 Neg γδ T Cellsmentioning

confidence: 96%

Direct and Indirect Effects of Cytomegalovirus-Induced Î³Î´ T Cells after Kidney Transplantation

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…CD8+ T-cells are mainly involved early after transplantation and are necessary to establish an immune response following primary infection, while CD4+ T-cells seem to be more implicated in establishing a long-term immune control against CMV [11]. Recent studies have also evaluated the antiviral role of other lymphocyte subpopulations, such as Treg, Th17, and γ-δ T-cells [12,13].…”

Section: Cell-mediated Immunity Assaysmentioning

confidence: 99%

Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients

Manuel

2013

Curr Infect Dis Rep

View full text Add to dashboard Cite

Novel strategies are needed to further reduce the burden of cytomegalovirus (CMV) disease in solid-organ transplant (SOT) recipients. Measurement of the specific cell-mediated immunity against CMV can identify the actual risk for the development of CMV disease in a given patient. Thus, immune monitoring is an attractive strategy for individualizing the management of CMV after transplantation. A growing number of observational studies on immune monitoring for CMV have been published over recent years, although there is a lack of data coming from interventional trials. In high-risk patients, measurement of CMV-specific T-cell responses appropriately stratifies the risk of CMV disease after discontinuation of antiviral prophylaxis. Immune monitoring may also help to identify patients followed by the preemptive approach at low risk for progression to CMV disease. Pretransplant assessment of cell-mediated immunity in seropositive patients may predict the development of posttransplant CMV infection. Overall, these studies indicate that the use of cell-mediated immunity assays has the potential to improve the management of CMV disease in SOT recipients.

show abstract

“…The expansion of CMV‐specific Vδ2‐negative γδ T cells was first observed in kidney transplant recipients but has subsequently been shown to occur in heart and lung transplant recipients and following HSCT . Longitudinal monitoring of γδ TCR repertoires in HSCT patients using next‐generation sequencing revealed that the CMV‐induced Vδ2‐negative γδ T cells were clonal in nature .…”

Section: Evidence For γδ T Cells In Favorable Outcomes Following Tranmentioning

confidence: 99%

“…19 However, the presence of CD16 + Vd2negative cd T cells may be problematic in transplant recipients with donor-specific antibodies because of their ability to lyse antibody-coated target cells. 51 The expansion of CMV-specific Vd2-negative cd T cells was first observed in kidney transplant recipients but has subsequently been shown to occur in heart and lung transplant recipients 57 and following HSCT. 58 Longitudinal monitoring of cd TCR repertoires in HSCT patients using nextgeneration sequencing revealed that the CMVinduced Vd2-negative cd T cells were clonal in nature.…”

Section: Nkg2a Ligandsmentioning

confidence: 99%

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

et al. 2019

View full text Add to dashboard Cite

Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under‐researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post‐transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation.

show abstract

Gamma-delta T cell expansion is closely associated with cytomegalovirus infection in all solid organ transplant recipients

Cited by 23 publications

References 14 publications

Direct and Indirect Effects of Cytomegalovirus-Induced Î³Î´ T Cells after Kidney Transplantation

Direct and Indirect Effects of Cytomegalovirus-Induced Î³Î´ T Cells after Kidney Transplantation

Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Contact Info

Product

Resources

About