Gamma-chain T-cell receptor transcripts are clonally expanded in the coronary arteries of cardiac allografts from patients with chronic rejection

Jung, Weon-Ju; Lu, Song; Qin, Pengfei; Afolabi, Abigail; Slachta, C.A.; Jeevanandam, Valluvan; Goldman, Bruce; Platsoucas, Chris D.

doi:10.1016/s0041-1345(00)02092-3

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Allograft Responses1

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“…γδ T cells accumulate in the endocardium and myocardium of patients over time, and clonal expansion of Vγ3Jγ2.1Cγ2 transcripts has been found in the coronary arteries of patients who experience chronic rejection 102,103,104. γδ T cells also have a role in the pathogenesis of cardiac allograft vasculopathy.…”

Section: Allograft Responsesmentioning

confidence: 99%

Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation

2018

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γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.

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Section: Allograft Responsesmentioning

confidence: 99%