Gamma camera imaging of osseous metastatic lesions by strontium-89 bremsstrahlung

Abstract

The aim of this study was to optimise the parameters affecting the Bremsstrahlung scintigraphy of patients injected with strontium-89 chloride. The parameters considered were : (1) instrumental detection efficiency, and (2) tissue attenuation factor for 89Sr calibrated sources, which permit quantitative evaluation of the activity in a given bone lesion. Some typical examples of in vivo 89Sr imaging are presented to illustrate the clinical utility of the imaging procedure developed by us, which is implemented in our department for all patients treated with 89Sr chloride.

Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radioembolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

“…The rise in the spectrum of about 150 keV reflects the penetration of the septa of the collimators by higher energy. The same phenomenon has been previously reported in 32 P, 90 Y, and 89 Sr BS measurements with a gamma camera [9–11, 13, 15, 27]. Although the maximum energies of 32 P and 90 Y are different (1.7 MeV vs. 2.27 MeV), their BS spectra appear to be similar.…”

“…In a quantitative study on the planar images using the phantom, Shen et al [9] showed that the sensitivity of the LEAP collimator was three times better than that of the MEGP collimator, whereas the system resolution of the MEGP collimator was three times better than that of the LEAP collimator. Similar results were obtained by Cipriani et al [15] and Shukla et al [13]. Therefore, most researchers working on BS imaging have used ME [7, 10, 11, 15, 25–30, 33–37] or HE collimators [16, 32].…”

“…Similarly, Tehranipour et al [37] described concordant findings from the 18 F-FDG PET and 90 Y-Bremsstrahlung scans after the RE of a hepatic tumor in one case report. The correspondence of the 99 mTc-MDP and 89 Sr BS images was also reported [15, 35, 40]. …”

Imaging atoms in medicine

“…52 Fe has been used to radiolabel blood cellular elements because offers a higher sensitivity and resolution than conventional imaging and has shown uptake in organs like the liver, brain or bone marrow (Ellis and Sharma 1999). There is a plethora of other radionuclides that also have been used for different medical procedures in patients: 82 Rb,201 Tl,188 Re,153 Gd,153 Sm,89 Sr,32 P,117m Sn,166 Ho,177 Lu,191 Pt,211 At, 51 Cr (Knesaurek et al 2007;Yu et al 2008;Xiong and Chen 2008;Jacobs et al 2004;Maini et al 2004;Cipriani et al 1997;Siegel and Khan 1996;Krishnamurthy et al 1997;Breitz et al 2006;Wehrmann et al 2007;Areberg et al 1999;Zalutsky et al 2008;Arnello et al 1999).…”

Systemic Radiotherapy of Bone Metastases With Radionuclides

“…Most of these reports detail qualitative assessment of 89 Sr uptake and its correlation with sites of abnormal uptake identified by diagnostic bone scans [26,27]. However, one report described the quantitation of uptake seen on 89 Sr images as part of their routine clinical assessment of patients receiving 89 Sr therapy [28]. Initially it was assumed that these quantitative images were based on bremsstrahlung emissions, as 89 Sr is a pure beta-emitter.…”