Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionine

Gleisner, Katarina Sjögreen; Elema, Dennis Ringkjøbing; Søndergaard, Lasse R.; Rasmussen, Palle; Fuglsang, Stefan; Ljungberg, Michael; Damgaard, Morten

doi:10.1017/s0007114513002559

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…None of the participants had undergone previous abdominal surgery (other than appendectomy) or was receiving any medication. Se-L-SeMet ( 75 Se-SeMet) was produced and delivered by Hevesy Laboratory, DTU Nutec, Technical University of Denmark, Roskilde, Denmark, as described previously (9) .…”

Section: Methodsmentioning

confidence: 99%

“…75 Se- l -SeMet ( 75 Se-SeMet) was produced and delivered by Hevesy Laboratory, DTU Nutec, Technical University of Denmark, Roskilde, Denmark, as described previously ( 9 ) .…”

Section: Methodsmentioning

confidence: 99%

“…However, it should be noticed that the doses used in the previously mentioned studies (7,8) were considerably larger (150-200 µg) than those administered in the present study (29 µg), which might affect the kinetics and thus hamper the comparability of our study to the previous studies. In an earlier study (9) , we had employed gamma camera imaging after oral intake of radio-labelled SeMet to quantify the gastrointestinal absorption capacity for SeMet and followed its postprandial distribution within the body. In the present study, we focused on dynamic gamma camera imaging with high temporal resolution to obtain data on both the intestinal absorption and the initial distribution * Corresponding author: J. L. Madsen, fax +45 3862 3750, email jan.lysgaard.madsen@regionh.dk…”

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Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

et al. 2015

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Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75 Se-L-SeMet ( 75 Se-SeMet). Scanning started simultaneously to the ingestion of 75 Se-SeMet and lasted 120 min. We generated timeactivity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants' data. The mean rate constant for 75 Se-SeMet transport was 2·63 h -1 from the stomach to the small intestine, 13·2 h -1 from the small intestine to the liver, 0·261 h -1 from the liver to the plasma and 0·267 h -1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75 Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function.Key words: Selenomethionine: 75 Se-L-selenomethionine: Absorption capacity: Metabolism: Gamma camera imaging: Compartmental modelling Selenomethionine (SeMet) is an important organic nutritional source of Se (1,2) . Absorption of various Se compounds occurs via different routes and mechanisms. Membrane transport of selenoamino acids, including SeMet, involves a specific suite of amino acid transporters (3) . The subsequent incorporation of dietary Se into selenoproteins occurs through a series of interconversions, of which many details remain unknown. Se metabolites are excreted in the urine and faeces and in exhaled air, mainly as selenosugars and methylated compounds (4) .The initial metabolism of Se in humans is poorly characterised. Estimates of Se absorption, whole-body retention and excretion have been made predominantly on whole-body counting (5) or the recovery of ingested tracers in the blood, urine and faeces (6) . Compartmental analyses of kinetic data from tracer studies have also been used to create a more integrated picture of whole-body Se utilisation in humans (7,8) . These studies characterised the long-term kinetics by the investigation of urine and faecal data collected over 12 d and blood samples drawn over 4 months. Through detailed mathematical modelling including several plasma pools, they were able to provide new insights into the long-run Se metabolism. However, because the study data only comprised hourly observations after dose administration, the initial Se kinetics could not be investigated and therefore still remained unclear. Our study tries to fill this gap and to provide deeper insight into the initial Se kinetics by focusing on frequent data collection within the first 2 h after a...

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Section: Methodsmentioning

confidence: 99%

“…75 Se- l -SeMet ( 75 Se-SeMet) was produced and delivered by Hevesy Laboratory, DTU Nutec, Technical University of Denmark, Roskilde, Denmark, as described previously ( 9 ) .…”

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

et al. 2015

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Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

2018

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The results for the body dose rate constant calculated in this work, for 30 radionuclides and 57 radiopharmaceuticals, and their effective half-lives, may be used to estimate the dose emitted by a person who has incorporated a radionuclide in the Nuclear Medicine activity range. This dose will be optimized when the body dose rate constant and the effective half-life determined in this study are used together with dose reduction factors.

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Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionine

Cited by 2 publications

References 25 publications

Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

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Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionine

Cited by 2 publications

References 25 publications

Absorption and initial metabolism of 75Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

Absorption and initial metabolism of 75Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

Determination of the dose rate constant through Monte Carlo simulations with voxel phantoms

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Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data

Absorption and initial metabolism of ⁷⁵Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data