Gamma band oscillations in the early phase of psychosis: A systematic review

Reilly, Thomas J.; Nottage, Judith; Studerus, Erich; Rutigliano, Grazia; Micheli, Andrea Ilario De; Fusar‐Poli, Paolo; McGuire, Philip

doi:10.1016/j.neubiorev.2018.04.006

Cited by 54 publications

(57 citation statements)

References 106 publications

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“…These neurochemical modulations mainly affect the basal forebrain and mesopontine regions ( Woolf and Butcher, 2011 ). Electrophysiologically, REM sleep dreams and psychotic states are accompanied by strongly attenuated activation and synchronicity in the gamma frequency band ( Voss et al, 2009 ; Gandal et al, 2012 ; McNally and McCarley, 2016 ; Reilly et al, 2018 ), suggestive of reduced conscious awareness and executive ego functions ( Desmedt and Tomberg, 1994 ; Cavinato et al, 2015 ). By contrast, a relative increase in gamma band activity is observed in lucid dreaming ( Voss et al, 2009 , 2014 ), and it would be interesting to explore if similar patterns can be identified in insightful psychoses.…”

Section: Consciousness In Dreams and Psychosismentioning

confidence: 99%

Insight and Dissociation in Lucid Dreaming and Psychosis

et al. 2018

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Dreams and psychosis share several important features regarding symptoms and underlying neurobiology, which is helpful in constructing a testable model of, for example, schizophrenia and delirium. The purpose of the present communication is to discuss two major concepts in dreaming and psychosis that have received much attention in the recent literature: insight and dissociation. Both phenomena are considered functions of higher order consciousness because they involve metacognition in the form of reflective thought and attempted control of negative emotional impact. Insight in dreams is a core criterion for lucid dreams. Lucid dreams are usually accompanied by attempts to control the dream plot and dissociative elements akin to depersonalization and derealization. These concepts are also relevant in psychotic illness. Whereas insightfulness can be considered innocuous in lucid dreaming and even advantageous in psychosis, the concept of dissociation is still unresolved. The present review compares correlates and functions of insight and dissociation in lucid dreaming and psychosis. This is helpful in understanding the two concepts with regard to psychological function as well as neurophysiology.

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Section: Consciousness In Dreams and Psychosismentioning

confidence: 99%

Insight and Dissociation in Lucid Dreaming and Psychosis

et al. 2018

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“…ASSR has been extensively studied before both in Sz and in rodent models. In Sz, the majority of studies have shown a reduction of ASSR power (e.g., (Hong et al, 2004;Kwon et al, 1999;Light et al, 2006;Reilly et al, 2018;Spencer et al, 2009;Thune et al, 2016), although increases are also reported (Hamm et al, 2012;Kim et al, 2019). Deficits are observed as well across the psychosis spectrum (Parker et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Translational neurophysiological biomarkers of N-methyl-D-aspartate receptor dysfunction in serine racemase knockout mice

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Abbas

et al. 2020

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Alterations in glutamatergic function are well established in schizophrenia (Sz), but new treatment development is hampered by the lack of translational pathophysiological and target engagement biomarkers as well as by the lack of animal models that recapitulate the pathophysiological features of Sz. Here, we evaluated the rodent auditory steady state response (ASSR) and long-latency auditory event-related potential (aERP) as potential translational markers. These biomarkers were assessed for their sensitivity to both the Nmethyl-D-aspartate receptor (NMDAR) antagonist phencyclidine (PCP) and to knock-out (KO) of Serine Racemase (SR), which is known to lead to Sz-like alterations in function of parvalbumin (PV)-type cortical interneurons. Both PCP and SRKO led to significant increases of ASSR, consistent with PV interneuron effects. Similar effects were observed in mice with selective NMDAR KO on PV interneurons. By contrast, PCP but not SRKO reduced the amplitude of the rodent analog of the human N1 potential. Overall, these findings support use of rodent ASSR and long-latency aERP, along with previously described measures such as mismatch negativity (MMN), as translational biomarkers, and support SRKO mice as a potential rodent model for PV interneuron dysfunction in Sz.

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“…This highlights the deficit in psychotic patients for modulating neural networks engaged during WM-related processes in an appropriate manner. Many studies have reported similar neurophysiological disturbances in gamma oscillation patterns in first-episode psychosis (FEP) patients (Lett et al 2014;Senkowski and Gallinat 2015;Başar-Eroglu et al 2007;Reilly et al 2018). Moreover, dysfunctional oscillations in magnetoencephalography delta (8-12 Hz) frequency ranges are present during the engagement of different processes of WM in schizophrenia (Ince et al 2009).…”

Section: Introductionmentioning

confidence: 90%

“…In schizophrenia, however, these gamma oscillations suffer a decrease of the intensity of their signal (for review, Reilly et al 2018). This results first from multiple pre-and postsynaptic receptor abnormalities in PVBCs (Lewis et al 2011;Lewis 2012).…”

Section: Introductionmentioning

confidence: 99%

Disruption of gamma–delta relationship related to working memory deficits in first-episode psychosis

et al. 2019

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Working memory (WM) deficits constitute a core symptom of schizophrenia. Inadequacy of WM maintenance in schizo-phrenia has been reported to reflect abnormalities in the excitation/inhibition (E/I) balance between pyramidal neurons and parvalbumin basket cells, which may explain alterations of the dynamics of gamma and delta oscillations. To address this issue, we assessed event-related gamma (35-45 Hz) and delta (0.5-4 Hz) oscillatory responses in a visual n-back WM task in patients with first-episode psychosis (FEP) and healthy controls (HC). Periodicity analyses of oscillations were computed to explore the relationship between the psychiatric status and the WM load-related processes reflected by each frequency range. The correspondence between nested delta-gamma oscillations was estimated to assess the strength of the frontal E/I balance. In HC, gamma oscillations were synchronized by the stimulus in a 50-150 ms time range for all tasks, and periodicity of the delta cycle was comparable between the tasks. In addition, synchronization of gamma oscillations in HC occurred at the maximal descending phase of the delta cycle half-period, supporting the coexistence of delta-nested gamma oscillations. Compared with controls, FEP patients showed a lack of gamma synchronization independently of the nature of the task, and the period of delta oscillation increased significantly with the difficulty of the WM task. We thus demonstrated in FEP an inability to encode multiple items in short-term memory associated with abnormalities in the relationship between oscillations related to the difficulty of the WM task. These results argue in favor of a dysfunction of the E/I balance in psychosis.

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Gamma band oscillations in the early phase of psychosis: A systematic review

Cited by 54 publications

References 106 publications

Insight and Dissociation in Lucid Dreaming and Psychosis

Insight and Dissociation in Lucid Dreaming and Psychosis

Translational neurophysiological biomarkers of N-methyl-D-aspartate receptor dysfunction in serine racemase knockout mice

Disruption of gamma–delta relationship related to working memory deficits in first-episode psychosis

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