Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1–42 oligomer injection

The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury

“…The current result might be due to the reduction of damage to the parietal cortex and hippocampus. The current result could be also supported by previous studies of CHD and its component herbs that demonstrated memory enhancing effects [48–52]. We could not identify the cause of the ineffectiveness of minocycline; it may be due to a statistical issue.…”

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

“…In our study, we build the AD model by injecting Aβ 25-35 aggregate into right ventricle, which is a widely used model to study AD [44, 45]. It has been reported that Aβ injection would cause memory impairment [46, 47], and the results in our study that the escape latency increased and the frequency of platform crossing decreased in MWM test of rats in model group also proved that. While the lower escape latency and higher frequency of platform crossing in OA group represent that OA could ameliorate Aβ-induced spatial learning and memory loss of AD rats.…”

Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimer’s Disease Mouse Model

“…The injection of Aβ 1-42 protein fragments into the ventricle, hippocampus, or other brain regions has been reported to have an ability to impair learning and memory [21][22][23]; In the Morris water maze test, mice treated with high doses of GRg1 and GRb1 showed superior performance to those in the AD group, indicating that ginsenosides can partly restore cognitive function in the AD model.…”