Game changers in science and technology - now and beyond

Betz, Ulrich; Arora, Loukik; Assal, R.A.; Azevedo, Hatylas; Baldwin, Jeremy; Becker, Michael; Bostock, Stefan; Cheng, Vinton W.T.; Egle, Tobias; Ferrari, Nicola; Schneider‐Futschik, Elena K.; Gerhardy, Stefan; Hammes, Alexandra; Harzheim, Achim; Herget, Thomas; Jauset, Cristina; Kretschmer, Simon; Lammie, Corey; Kloss, Nina; Fernandes, Steve Marquis; Mitrofan, Claudia-Gabriela; Myrgorodska, Iuliia; Nedbalek, Daniela; Neumann, Siegfried G.; Paffenholz, Stella V; Ponce, Laia Pascual; Rogell, Birgit; Savic, Dragana; Velikova, Gergana; Schumacher, Christian; Weisshaar, Nina; Yahya, Mohammadzadeh; Yang, Joshua; Zhao, Guoping

doi:10.1016/j.techfore.2023.122588

Cited by 42 publications

(20 citation statements)

References 269 publications

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“…These indicators would lead to identification of trends of future scientific and technological achievements in the area of advanced nanomaterials, which in turn would be one information element when examining possible impacts on society and policy implications associated to these areas. Often new technology matures and evolves from being a new research field to becoming applied science, 53 and products containing the technology are becoming available also to the general public. Thus, taken collectively the indicators for advanced materials reflect that today’s advanced material is tomorrow’s standard.…”

Section: Discussionmentioning

confidence: 99%

Advanced materials foresight: research and innovation indicators related to advanced and smart nanomaterials

Farcal,

Munoz Pineiro,

Riego Sintes

et al. 2023

F1000Res

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Background: Advanced materials are most likely to bring future economic, environmental and social benefits. At the same time, they may pose challenges regarding their safety and sustainability along the entire lifecycle. This needs to be timely addressed by the stakeholders (industry, research, policy, funding and regulatory bodies). As part of a larger foresight project, this study aimed to identify areas of scientific research and technological development related to advanced materials, in particular advanced nanomaterials and the sub-group of smart nanomaterials. The study identified and collected data to build relevant research and innovation indicators and analyse trends, impact and other implications. Methods: This study consisted of an iterative process including a documentation phase followed by the identification, description and development of a set of core research and innovation indicators regarding scientific publications, EU projects and patents. The data was extracted mainly from SCOPUS, CORDIS and PATSTAT databases using a predefined search string that included representative keywords. The trends, distributions and other aspects reflected in the final version of the indicators were analysed, e.g. the number of items in a period of time, geographical distribution, organisations involved, categories of journals, funding programmes, costs and technology areas. Results: Generally, for smart nanomaterials the data used represent around 3.5% of the advanced nanomaterials data, while for each field analysed, they represent 4.4% for publications, 13% for projects and 1.1% for patents. The study shows current trends for advanced nanomaterials at a top-level information that can be further extended with sub-indicators. Generally, the results indicated a significant growth in research into advanced nanomaterials, including smart nanomaterials, in the last decade, leading to an increased availability of information. Conclusion: These indicators identify trends regarding scientific and technological achievements and represent an important element when examining possible impacts on society and policy implications associated to these areas.

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Section: Discussionmentioning

confidence: 99%

Advanced materials foresight: research and innovation indicators related to advanced and smart nanomaterials

Farcal,

Munoz Pineiro,

Riego Sintes

et al. 2023

F1000Res

View full text Add to dashboard Cite

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“…The research conducted in these years has not only paved the way for groundbreaking therapeutic strategies but has also illustrated the extraordinary capacity for resilience and innovation within the scientific community ( Rijs and Fenter, 2020 ). These advancements, born out of necessity in the face of global health crises ( Betz et al, 2023 ), have reshaped the landscape of infectious disease treatment and prevention.…”

Section: The Landscape Of Infectious Diseases Post-pandemic: a Pharma...mentioning

confidence: 99%

Editorial: The evolution in pharmacology of infectious diseases: 2022

Porta,

Saffaei,

Kalesh

2024

Front. Pharmacol.

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“…The use of chiral auxiliaries or enantiomerically pure starting materials from natural sources is costly in general and inefficient. Therefore, the development of highly efficient methods and processes in catalytic asymmetric synthesis has profound significance in the pharmaceutical industry, which needs to develop efficacious and safe chiral drugs with high target specificity ( Betz et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in catalytic asymmetric synthesis

Garg,

Rendina,

Bendale

et al. 2024

Front. Chem.

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Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catalytic reactions, which spans various methodologies, each contributing to the broader landscape of the enantioselective synthesis of chiral molecules. Transition metals play a central role as catalysts for a wide range of transformations with chiral ligands such as phosphines, N-heterocyclic carbenes (NHCs), etc., facilitating the formation of chiral C-C and C-X bonds, enabling precise control over stereochemistry. Enantioselective photocatalytic reactions leverage the power of light as a driving force for the synthesis of chiral molecules. Asymmetric electrocatalysis has emerged as a sustainable approach, being both atom-efficient and environmentally friendly, while offering a versatile toolkit for enantioselective reductions and oxidations. Biocatalysis relies on nature’s most efficient catalysts, i.e., enzymes, to provide exquisite selectivity, as well as a high tolerance for diverse functional groups under mild conditions. Thus, enzymatic optical resolution, kinetic resolution and dynamic kinetic resolution have revolutionized the production of enantiopure compounds. Enantioselective organocatalysis uses metal-free organocatalysts, consisting of modular chiral phosphorus, sulfur and nitrogen components, facilitating remarkably efficient and diverse enantioselective transformations. Additionally, unlocking traditionally unreactive C-H bonds through selective functionalization has expanded the arsenal of catalytic asymmetric synthesis, enabling the efficient and atom-economical construction of enantiopure chiral molecules. Incorporating flow chemistry into asymmetric catalysis has been transformative, as continuous flow systems provide precise control over reaction conditions, enhancing the efficiency and facilitating optimization. Researchers are increasingly adopting hybrid approaches that combine multiple strategies synergistically to tackle complex synthetic challenges. This convergence holds great promise, propelling the field of asymmetric catalysis forward and facilitating the efficient construction of complex molecules in enantiopure form. As these methodologies evolve and complement one another, they push the boundaries of what can be accomplished in catalytic asymmetric synthesis, leading to the discovery of novel, highly selective transformations which may lead to groundbreaking applications across various industries.

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Game changers in science and technology - now and beyond

Cited by 42 publications

References 269 publications

Advanced materials foresight: research and innovation indicators related to advanced and smart nanomaterials

Advanced materials foresight: research and innovation indicators related to advanced and smart nanomaterials

Editorial: The evolution in pharmacology of infectious diseases: 2022

Recent advances in catalytic asymmetric synthesis

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