Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings

Wang, Shengpeng; Xu, Yingqi; Li, Chenyang; Tao, Hongxun; Wang, Anqi; Sun, Chenyu; Zhong, Zhangfeng; Wu, Xu; Wang, Ying

doi:10.1016/j.fct.2018.02.037

Cited by 17 publications

(13 citation statements)

References 35 publications

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“…Many studies have reported the anti-cancer effects of GA in human breast cancer [647][648][649][650]. GA at low concentrations (0.3-1.2 μM) can inhibit cell invasion without affecting cell viability, while high concentrations of GA (3 and 6 μM) can induce apoptosis via ROS accumulation and mitochondrial apoptotic pathway in human breast cancer MDA-MB-231 cells [651].…”

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Gambogic Acid (Ga)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…In breast cancer cells, gambogic acid increased sensitivity of TRAIL and increased TRAIL-induced apoptosis in cancer cells. Wang et al (2018) discovered that GA with TRAIL cooperation decreased anti-apoptotic proteins level and activated Bid (BH3 interacting-domain death agonist) which promoted cross talk between extrinsic and intrinsic apoptotic signaling, instead of enhancing the TRAIL DR4 and DR5 receptors (Wang et al, 2018b). Different researchers and investigators determined that encapsulation of GA with polyethylenimine-poly (d,l-lactide-coglycolide) caused momentous augmentation in apoptotic cell death in an in vitro study on triplenegative breast cancer, and in vivo suppression of TNBC tumor growth (Wang et al, 2017;.…”

Section: Breast Cancermentioning

confidence: 99%

“…Inhibited proliferation and induced apoptotic cell death (Wang et al,2018a;Sang et al, 2018). Increased the sensitivity of breast cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) Enhanced TRAIL-induced apoptosis (Wang et al, 2018b).…”

Section: Mechanisms References Breast Cancermentioning

confidence: 99%

Gambogic Acid as Anticancer Agent: A Review

Gilani¹,

Imran²,

Haq³

et al. 2020

Preprint

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Gambogic acid, a common traditional Chinese medicine and widely distributed throughout South China, Vietnam, Cambodia, and Thailand. It is prenylated xanthone which is the significant bioactive compound of gamboge. Gambogic acid is known as a strong apoptotic inducer in cancer cells. It has been found as strong anticancer agent against various types of cancer cells lines such as breast cancer, pancreatic, and cervical cancer. It induces apoptosis, down regulates the anti-apoptotic proteins (survivin and BCL2,) and down regulates the activities of P-glycoprotein in drug sensitive human breast MCF-7 and drug-resistant MCF-7/ADR cells. Similarly, it also exerts alteration in P13K, AKT, p21, MMP-2 &-9, and phosphorylated-AKT expressions. The current review highlights the anticancer and chemo-preventive perspectives of gambogic acid and its mechanistic role against human and animal cancers.

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“…They resulted in enhanced TRAIL induced apoptosis for gambogic acid in a dose-dependent manner. 6 In recent years, lichens and their secondary metabolites have attracted attention as novel candidate molecules for cancer treatment. 7,8 Usnic acid (UA) is the most abundant lichen secondary metabolite, which plays significant roles in different biological activities, mainly antibacterial, antifungal, antiviral, cytotoxic, and antioxidant activity in addition to antiherbivore and insecticidal activity.…”

Section: Introductionmentioning

confidence: 99%

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

Özben

Cansaran-Duman

2020

Hum Exp Toxicol

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This study aims to determine whether usnic acid (UA) could induce the expression of apoptosis-related genes in apoptosis pathway. The current study has enabled us to better understand the target of UA in the treatment of breast cancer. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Based on the previous study and the results of this study, UA had the most antiproliferative effect on SK-BR-3 breast cancer cell line. We examined differential expression of 88 apoptosis-related genes by quantitative real-time polymerase chain reaction using the apoptosis primary library panel in SK-BR-3 breast cancer cell. We observed a difference in the significant differential expression of 74 apoptosis-related genes in breast cancer after SK-BR-3 cells applied to UA (7.21 µM) for 48 h. The expression level of 56 of these 74 differentiated apoptosis-related genes increased ( p < 0.05), but the expression level of the other 18 related genes decreased ( p < 0.05). In order to evaluate the mechanism of apoptosis of UA, Western blot analysis was performed with Bcl-2, Bax, Caspase-3, and Caspase-9 antibodies. According to the Western blot analysis, we obtained similar results with gene-expression data. These results suggest that UA showed a cytotoxic effect in SK-BR-3 cells through activation of the mitochondrial apoptotic pathway. The obtained results from gene expression revealed that the effect of UA on apoptosis pathway is critical for clinical research.

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Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings

Cited by 17 publications

References 35 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Gambogic Acid as Anticancer Agent: A Review

The expression profiles of apoptosis-related genes induced usnic acid in SK-BR-3 breast cancer cell

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