Gambling associated risk-taking decision in cerebellar ataxia

Lai, Ruo-Yah; Desai, Natasha; Amlang, Christian; Lin, Chi‐Ying; Chen, Tiffany X.; Minyetty, Michael J.; Amokrane, Nadia; Kuo, Sheng‐Han

doi:10.1016/j.parkreldis.2022.105252

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…The “internal model” hypothesis suggests that the cerebellum can reproduce cortical psychology by encoding internal models ( Ito, 2008 ). Additionally, research has demonstrated that the cerebellum plays a role in decision-making calculations ( Deverett et al, 2018 ), and studies have found that patients with cerebellar injury are more likely to make decision-making errors ( Lai et al, 2023 ; van der Giessen et al, 2023 ). Another study concluded that the cerebellum is not directly involved in attentional functions and likely plays a role by coordinating and managing levels of activation or inhibition in cortical areas ( Mannarelli et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

The influence of cerebellum on visual selective attention in patients with multiple lacunar cerebral infarction and its neuromodulatory mechanisms

Yuan,

Duan,

et al. 2024

Front. Hum. Neurosci.

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ObjectiveThis study aims to investigate the influence of the cerebellum on visual selective attention function and its neuromodulatory mechanism in patients with multiple lacunar cerebral infarction (MLCI).MethodsA retrospective analysis was conducted on 210 patients admitted with MLCI from January 2016 to May 2022. Analyzed the electrophysiological characteristics of the P3a and P3b components of vision in both groups, as well as source reconstruction simulations of dipole activation in the brains of the two groups, and analyzed the brain regions with differences in activation strength between the two groups.ResultsThis study found that there was no significant difference in peak amplitude between the two groups, but compared with the control group, the peak latency of the case group was significantly prolonged. Specifically, the P3a peak latency induced by the novel stimulus was longer than that induced by the target stimulus P3b peak latency. Source reconstruction results showed decreased and increased activation in several brain regions in the case group compared to the control group.ConclusionThe study suggests that the impairment of distracted attention capture is more pronounced in patients with MLCI. The cerebellum indirectly influences the ventral and dorsal frontoparietal attention networks by modulating the levels of excitation and inhibition within the cerebral cortex of the attention network. This may represent a potential mechanism through which the cerebellum regulates visual selective attention information in MLCI patients.

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Section: Discussionmentioning

confidence: 99%

The influence of cerebellum on visual selective attention in patients with multiple lacunar cerebral infarction and its neuromodulatory mechanisms

Yuan,

Duan,

et al. 2024

Front. Hum. Neurosci.

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“…This is in line with previous research that has reported decreased white matter integrity within the anterior lobe of the left cerebellum in schizophrenic patients (Wei et al, 2011). Also, patients with cerebellar ataxia demonstrate a higher prevalence of impulsive behaviors (Chen et al, 2022a; Lai et al, 2023). Moreover, altered frontocerebellar functional connectivity has been observed in patients with higher impulsivity (Jung et al, 2014; Piccoli et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

White Matter Correlates of Impulsive Behavior in Healthy Individuals: A Diffusion MRI Study

Rashidi,

Parsaei,

Kiani

et al. 2023

Preprint

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Background: Impulsivity is closely related to the tendency to engage in risky behaviors. Previous research identified macrostructural brain alterations in individuals exhibiting impulsive behaviors. Understanding the microstructural brain changes linked to impulsivity can elucidate its underlying mechanisms and guide effective treatment strategies. In this study, we employed diffusion magnetic resonance imaging (DMRI) connectometry to investigate white matter tracts associated with impulsivity while considering potential sex differences. Methods: We enrolled 218 healthy participants from the Leipzig Study for Mind-Body-Emotion Interactions (LEMON) database. Correlations between DMRI-derived white matter changes and impulsivity were assessed using scores from the UPPS Impulsive Behavior Scale's four subscales (lack of perseverance (PE), lack of premeditation (PM), sensation seeking (SS), and negative urgency (NU)). Results: Our findings revealed negative correlations between quantitative anisotropy (QA) values in bilateral cerebellum, middle cerebellar peduncle (MCP), and the severity of PE and PM across the cohort. Additionally, QA values within MCP, corpus callosum (CC) body, and forceps major exhibited negative correlations with SS. Conversely, QA values in forceps minor were positively correlated with PM, and QA values in both the forceps minor and bilateral cingulum showed positive correlations with SS. Remarkably, the observed correlations between UPPS subscale scores and QA value alterations within white matter tracts varied between males and females. Conclusions: Impulsivity is correlated with discernible alterations in white matter integrity across diverse tracts, including CC, cerebellum, and cingulum. Moreover, males and females show distinct patterns of correlations between white matter integrity and impulsivity.

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“…2 In addition to the motor symptoms, individuals with SCA may also exhibit non-motor symptoms such as impaired cognitive and emotional processing, psychiatric changes, impulse control disorders, and fatigue, among others. [3][4][5] Fatigue is a common symptom in neurologic conditions, including movement disorders such as Parkinson's disease (14%-91%), multiple system atrophy (61%-87.2%), dystonia (36%-76.3%), and essential tremor (30%-52.5%). [6][7][8][9] Although fatigue is also recognized in SCA patients, 10 the factors contributing to fatigue and fatigue's impact on SCAs have not been thoroughly studied.…”

mentioning

confidence: 99%

“…SCAs are characterized by a variety of motor symptoms including gait difficulty, oculomotor disturbances, dysarthria, and loss of limb dexterity 2 . In addition to the motor symptoms, individuals with SCA may also exhibit non‐motor symptoms such as impaired cognitive and emotional processing, psychiatric changes, impulse control disorders, and fatigue, among others 3–5 . Fatigue is a common symptom in neurologic conditions, including movement disorders such as Parkinson's disease (14%–91%), multiple system atrophy (61%–87.2%), dystonia (36%–76.3%), and essential tremor (30%–52.5%) 6–9 .…”

mentioning

confidence: 99%

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

Lai,

Rummey,

Amlang

et al. 2024

Movement Disord Clin Pract

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BackgroundFatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.ObjectivesTo study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.MethodsFatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi‐variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.ResultsFatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi‐variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.ConclusionsFatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.

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Gambling associated risk-taking decision in cerebellar ataxia

Cited by 8 publications

References 27 publications

The influence of cerebellum on visual selective attention in patients with multiple lacunar cerebral infarction and its neuromodulatory mechanisms

The influence of cerebellum on visual selective attention in patients with multiple lacunar cerebral infarction and its neuromodulatory mechanisms

White Matter Correlates of Impulsive Behavior in Healthy Individuals: A Diffusion MRI Study

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

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