Gamascintigraphic in Vivo-in Vitro Evaluation of Floating Matrix Tablet

Abstract

Background of the work: Gastroretentive drug delivery system can retain the dosage form in the gastric region for several hours. Prolong gastric retention helps in improving bioavailability and improves solubility of drugs that are less soluble in a high pH environment. For designing of GRDDS Atenolol was selected as a model drug. It has been used for the treatment of hypertension. Atenolol has short elimination half-life, stable at pH 1.2 and as the pH increase, the drugs becomes unstable and thus low oral bioavailability.In order to improve its therapeutic effectiveness Atenolol is designed in the form of floating tablet formulation. Purpose: The aim of the present

Polymeric Excipients in the Technology of Floating Drug Delivery Systems

“…Xanthan gum [32] HPMC K 15M, NA [100] Egg albumin [46] EC, HPMC K4M [48] HPMC K4M, HPMC K100M, HPMC K100LV [52] HPMC K4M [53] NaCMC (2000 cP), HPMC K4M [56] HPMC K4M [101] HPMC E 15LV [102] HPMC K4 M, HPMC E5LV [103] HPMC K100 M CR [104] PEO (molecular mass: 1,000,000-7,000,000) [70] Carbomer (Carbopol 934), HPMC K4M [79] Carbomer (Carbopol 934P), HPMC K4M, HPMC E50 [80] HPMC K15 M, Carbomer (Carbopol 971 P NF), NaCMC [105] HPMC K15 M, EC, Gum [106] HPMC K4 M, Carbomer (Carbopol 974P) MA [107] HPMC K100 M, Mucus secreted from Hibscus rosa-sinensis, Carbomer (Carbopol 934P) MA [108] HPMC K4 M, HPMC K15 M, PEO (Polyox 303WSR) [109] NaCMC, PEO (Polyox 303WSR), Carbomer (Carbopol 934P) [110] HPMC K4 M, Locust bean gum [111] EC, HPMC K100 M [112] HPMC K15 M, Carbomer (Carbopol 971P) [75] NA, HPC [113] Carbomer (Carbopol 934P), NA, HPMC K4 M, PVP [114] HPMC K4 M, PVP K30 [115] Graft copolymer of polyacrylamide and corn fiber gum MA [116] Carbomer (Carbopol 934P), PEO (Polyox N-60K) [117] PEO (Polyox WSR205), Xanthan gum [118] HPMC K100 M, Carbomer (Carbopol 971P) [119] Tablets (wet granulation)…”