Abstract:Hepatocellular carcinoma (HCC) is a malignant tumor with
a high
rate of recurrence and a poor prognosis. Here, we investigated the
effect and the potential antitumor mechanism of Gamabufotalin (CS-6)
against HCC. Our results show that CS-6 strikingly reduced cell viability,
inhibited colony formation, and promoted apoptosis in Hep3B and Huh7
cells. In vivo, CS-6 inhibited HCC xenograft tumor growth with no
toxicity to normal tissues. Mechanistically, we found that CS-6 could
induce cytoprotective autophagy thr… Show more
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