GALNT4 promotes the endothelial cell inflammatory response via the NF-κB signaling pathway
Li Wei Guo,
Lulu Zhou,
Pengcheng Wei
et al.
Abstract:Background
Atherosclerosis (AS) is a chronic inflammatory disease caused by dysfunction of vascular endothelial cells (ECs). Polypeptide N-acetylgalactosaminyl -transferase 4 (GALNT4) modifies target proteins via O-N-acetylgalactosamine (O-GalNAc) glycosylation, which is known to play a crucial role in regulating the inflammatory response in AS, but its exact function in ECs is yet to be determined.
Objective
This study aims to investigate the effect of GALNT4 on endothelial cell inflammation and AS.
Methods… Show more
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