GalNAc- or Mannose-PEG-Functionalized Polyplexes Enable Effective Lectin-Mediated DNA Delivery
Ricarda C. Steffens,
Paul Folda,
Nikole L. Fendler
et al.
Abstract:A cationic,
dendrimer-like oligo(aminoamide) carrier with four-arm
topology based on succinoyl tetraethylene pentamine and histidines,
cysteines, and N-terminal azido-lysines was screened
for plasmid DNA delivery on various cell lines. The incorporated azides
allow modification with various shielding agents of different polyethylene
glycol (PEG) lengths and/or different ligands by copper-free click
reaction, either before or after polyplex formation. Prefunctionalization
was found to be advantageous over post… Show more
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