Gallstones increase the prevalence of Barrett’s esophagus

Abstract

The presence of gallstones was independently associated with the presence of ESEM in the Japanese outpatient population, suggesting a causal association of distal esophageal bile exposure with the development of ESEM. Further studies are needed to confirm our findings in cases with histologically confirmed Barrett's esophagus.

Does Bile Reflux Influence the Progression of Barrett's Esophagus to Adenocarcinoma? (Gastroenterology 2013;145:1300-1311)

“…It is a premalignant lesion that is detected in a majority of patients with EAC. Gastroesophageal reflux disease (GERD) and bile reflux are known to cause BE and EAC 1. Caudal-related homologue 2 (CDX2), is a homeodomain transcription factor that regulates normal intestinal cell differentiation by functioning as a tumor suppressor protein, and its expression levels are associated with the prognosis of adenocarcinomas.…”

Etiological difference between ultrashort- and short-segment Barrett’s esophagus

“…In addition, a positive association was also observed between the presence of gastric corpus atrophy and that of BE [10]. However, several studies have shown an inverse association between the presence of gastric mucosal atrophy and of H. pylori infection and that of BE [11].…”

“…We recently conducted a case-control study and reported that the presence of gallstones was associated with an increase in the risk of BE [10]. In addition, a positive association was also observed between the presence of gastric corpus atrophy and that of BE [10].…”

“…The design and the primary results of the case-control study have been reported [10]. Among the 4945 patients who underwent esophagogastroduodenoscopy (EGD) at Keio University Hospital between November 2007 and April 2008, 528 patients with ESEM were allocated to the case group, while 528 age-and gender-matched (frequency-matching) subjects without ESEM were allocated to the control group.…”

“…Using a logistic regression model with adjustments for age and gender, we detected a strong association between the with ESEM and 528 age-and gender-matched subjects without ESEM were selected [10]. Of the 528 patients with ESEM, 317 were assigned to the US-ESEM group, and of the 528 subjects without ESEM, 317 age-and gender-matched subjects were assigned to the non-ESEM control group.…”