Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome

Yener, Oktay; Aksoy, Fikret; Demır, Mustafa; Özçelik, Alp; Erengül, Canan

doi:10.4318/tjg.2010.0128

Cited by 26 publications

(26 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results are in accordance with another study with similar objective [29]. However presence of normal ranges of liver enzymes does not exclude NAFLD as rectified by some other series [19], [40]. Mofrad et al.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

Ahmed

Baloch

Memon

et al. 2017

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

ObjectiveRecognition of Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome in patients with gallstones undergoing laparoscopic or open cholecystectomy, along with it we will also study the life style of patients with gall stones.BackgroundPatients with gallstones have associated NAFLD, with concurrent metabolic syndrome and these ailments share similar factors for example obesity, hypertriglyceridemia and diabetes mellitus. Factors like body mass index, gender, raised lipid levels, use of contraceptives and alcohol and having diabetes, physical inactiveness, multiparous women, water with excessive iron content, metabolic syndrome, and NAFLD are accountable factors for gallstones formation.MethodologyThis was a case series done at Surgical Unit 1 of Civil Hospital Karachi. Selective samples of 88 patients were included. Duration was 3 months. We included both sexes with ultrasound proof of gall stone irrespective of cholecystitis. Excluded patients with history of seropositive viral hepatitis, autoimmune and wilson's disease. As these conditions can act as a confounder to our variables.ResultsNafld was present in 62.5%(n = 55) while 28.4% (n = 25) had metabolic syndrome. 26.94% had BMI less than 18, 32.12 had BMI between 18 and 25 and majority had BMI greater than 25 i.e in 40.93%. Of all 46.6% had a family history of cholelithiasis. Gallstone patients with NAFLD reported about their first degree relative being suffering from cholelithiasis at a significant p-value of 0.034 while this was not significant in cases of metabolic syndrome and the p -value was 0.190.ConclusionWe found association of metabolic syndrome with gallstones and NAFLD. Non alcoholic fatty liver was highly prevalent in our study subjects. Huge percentage of first degree relatives of gall stone patients had gallstones and this relation was more pronounced patients who had associated NAFLD.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Selective samples of 88 patients were included in this which was calculated by www.OpenEpi.com taking the population size of 95 at 95% CI and 3% margin of error [19]. Duration was 3 months.…”

Section: Methodsologymentioning

confidence: 99%

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

Ahmed

Baloch

Memon

et al. 2017

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

show abstract

“…Because hepatic steatosis is currently considered as the hepatic manifestation of the MS,7,8 interest is mounting on the potential relationships between NAFLD and GD 12,13,14,15,16,17,18,19,20. To our knowledge, this is one of the largest report to date focusing on the association between biopsy-proven NAFLD and GD.…”

Section: Discussionmentioning

confidence: 91%

“…Similar to NAFLD, gallstone disease (GD) is highly prevalent in Western countries and has been pathogenetically linked with the MS 9,10,11. Accordingly, the two conditions share a number of risk factors, including obesity, diabetes, dyslipidemia, and hyperinsulinemia 12,13. Of note, the prevalence of nonalcoholic steatohepatitis (NASH) in GD has been reported to be as high as 18% in the morbid obese population 14.…”

Section: Introductionmentioning

confidence: 99%

Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease

et al. 2014

View full text Add to dashboard Cite

Background/AimsWe sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score.MethodsWe included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the presence of sonographic evidence of gallstones, echogenic material within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallbladder at ultrasonography, coupled with a history of cholecystectomy.ResultsFifty-four patients (12.2%) had GD (GD+ subjects). Compared with the GD- subjects, GD+ patients were older, had a higher body mass index and were more likely to be female and have metabolic syndrome. However, GD+ patients did not have a higher risk of advanced fibrosis or definite NASH on histology. After adjustment for potential confounding variables, the prevalence of GD in NAFLD patients was not associated with significant fibrosis (≥2) (odds ratio [OR], 1.06; 95% confidence interval [CI], 0.53 to 2.21; p=0.68) or definite NASH (OR, 1.03; 95% CI, 0.495 to 2.12; p=0.84).ConclusionsThe presence of GD is not independently associated with advanced fibrosis and definite NASH in adult Turkish patients with biopsy-proven NAFLD.

show abstract

“…Other studies involving Chinese populations have similar results to our study. Alcohol abuse in-creases the risk of gallstone formation because of liver damage and reduced bile salt synthesis; therefore, alcoholic cirrhosis is a strong independent risk factor for gallstone formation in the general population (30)(31)(32). Bile salt synthesis is reduced in transplant recipients because of liver failure; thus, the gap between alcoholism and other factors is reduced.…”

Section: Shi Et Al Gallstones Subjected To Liver Transplantationmentioning

confidence: 99%

Gallstones in liver transplant recipients: A single-center study in China

Shi¹,

Shen²,

Teng³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: Liver transplant recipients include patients who present with almost all kinds of end-stage liver disease. Studying the relationship between gallstones and end-stage liver disease among liver transplant recipients is becoming important. Materials and Methods: Multiple logistic regression analysis was applied to assess 1640 liver transplant recipients. Multiple factors were involved in the analysis, including age, sex, total bilirubin and total cholesterol levels, Child score, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, alcoholic cirrhosis, and hepatocellular carcinoma (HCC). Results: Age and Child score are independent risk factors for the development of gallstone disease (GD). The average age of the recipients in the GD group was 49.22±9.96 years, which was significantly higher than that in the GD-free group (48.23±9.79 years). The Child score of the recipients in the GD group was 9.21±2.47, which was significantly lower than that of the recipients in the GD-free group, which was 8.79±2.48 (t=3.23, p<0.001). We also found that hepatitis B is an influential factor in GD. Conclusion: The prevalence of gallstones among liver transplant recipients is related to the Child score and patient age. The prevalence of GD is lower in patients with HCC and in those who are HBV positive and is relatively higher in HCV-positive patients and in those with alcoholic cirrhosis, although no significant differences were found.

show abstract

Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome

Cited by 26 publications

References 20 publications

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

Gallstone Disease Does Not Predict Liver Histology in Nonalcoholic Fatty Liver Disease

Gallstones in liver transplant recipients: A single-center study in China

Contact Info

Product

Resources

About