Gallstone disease risk in relation to body mass index and waist-to-hip ratio in Japanese men

Kodama, Hiroko; Kono, Shoko; Todoroki, Isao; Honjo, Satoshi; Sakurai, Yoshinori; Wakabayashi, Kazuo; Nishiwaki, Masato; Hamada, Hatsuyuki; Nishikawa, Hiroshi; Koga, Hironori; Ogawa, Sumito; Nakagawa, Katsuya

doi:10.1038/sj.ijo.0800781

Cited by 32 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 1 In men, prevalence of gallstones is associated independently not only with BMI, but also with the waist‐to‐hip circumference ratio, which is an index of central adiposity. 2 In women, the prevalence of a self‐reported history of gallstone disease was also highest in the quartile with the highest waist‐to‐hip ratio, alongside with hypertension and diabetes. 3 These data are suggestive (although a clear‐cut relationship is still far from being established) of an association between gallstone disease in obesity and the metabolic syndrome linked to central adiposity, the cardinal feature of which is represented by hyperinsulinaemia.…”

Section: Introductionmentioning

confidence: 99%

Review article: gall‐bladder motor function in obesity

Petroni

2000

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary A number of epidemiological studies has established obesity as a risk factor for gallstone disease. More recently, studies have suggested a relationship between gallstone disease and the metabolic syndrome linked to central adiposity, whose cardinal feature is represented by hyperinsulinaemia. Studies on fasting gall‐bladder volume in obese subjects show that this parameter correlates with weight, body mass index (BMI) and body surface area; however, this is also true for large‐sized non‐obese subjects. Gall‐bladder volume also correlates with abdominal fat and with impaired glucose tolerance. In contrast to the well‐established role of bile supersaturation in the pathogenesis of gallstones in obesity, data are controversial on whether gall‐bladder motor function is defective in obese subjects. However, studies were heterogeneous for subjects' BMI, emptying stimulus, technique used and parameters assessed to evaluate gall‐bladder motor function. Also, differences in baseline gall‐bladder volume may lead to wide differences in bile ‘washout' effect despite apparently similar percentage changes in volume or content. Although post‐prandial plasma levels of cholecysto‐ kinin (CCK) are normal in obese subjects, there is some evidence that a sub‐group of obese subjects could have decreased sensitivity to CCK, possibly mediated by hyperinsulinaemia. Further studies using standard physiological stimuli and controlling for glucose tolerance, fasting insulin levels and baseline gall‐bladder volume are needed to establish the role of gall‐bladder motor function in the pathogenesis of gallstone disease in obesity.

show abstract

Section: Introductionmentioning

confidence: 99%

Review article: gall‐bladder motor function in obesity

Petroni

2000

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…These factors are components of metabolic syndrome, which is a cluster of related conditions (i.e., abdominal obesity, high blood pressure, high plasma glucose, high triglycerides, and decreased high-density lipoprotein cholesterol (HDL); (Cowey and Hardy, 2006)). While individual components of metabolic syndrome have been linked to biliary tract cancers and biliary stones (Maclure et al , 1989; Kodama et al , 1999; Tsai et al , 2004; Andreotti et al , 2008; Seidell, 2010), the total effect of metabolic syndrome on these two conditions has not been investigated fully.…”

mentioning

confidence: 99%

Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China

et al. 2011

View full text Add to dashboard Cite

Background:Serum lipids, diabetes, and obesity, individual components of metabolic syndrome, are associated with biliary tract cancer and stone risk, but the associations of metabolic syndrome or insulin resistance with biliary tract cancers and stones are not well studied.Methods:In this population-based case-control study in Shanghai, China (627 biliary tract cancers, 1037 biliary stones, and 959 controls), metabolic syndrome was defined as the presence of any three of the five components, including high waist circumference, high triglycerides, low high-density lipoprotein cholesterol (HDL), high blood pressure, and diabetes. Insulin resistance and β-cell function were assessed, using homeostasis assessment models.Results:Metabolic syndrome was significantly associated with gallbladder cancer (odds ratio (OR)=2.75, 95% confidence interval (95% CI)=1.82–4.15) and biliary stones (OR=1.64, 95% CI=1.24–2.16), with a significant dose effect with increasing number of metabolic syndrome components (P trend <0.0001). The observed association persisted among subjects without a history of diabetes. The association between insulin resistance and gallbladder cancer was borderline (P trend=0.06). There was a significant inverse association between β-cell function and gallbladder cancer risk (P trend <0.001).Conclusion:Our findings suggest that metabolic syndrome and insulin resistance have a role in the aetiology of biliary tract cancers and biliary stones, and if confirmed, they imply that lifestyle control of these factors may lower the risk of biliary stones and biliary tract cancer.

show abstract

“…High BMI is a crucial risk factor for some common cancers,26 but may not be a risk factor for prostate cancer. Some evidence indicates that BMI is positively associated with the incidence of gallstone disease,27–29 suggesting an important role in the relationship between history of cholelithiasis and the risk of prostate cancer. The HR was increased in the category of subjects with higher BMI (≥25 kg/m 2 ), indicating an intensified risk for the subjects with both history of cholelithiasis and higher BMI.…”

Section: Discussionmentioning

confidence: 99%

History of cholelithiasis and the risk of prostate cancer: The Ohsaki Cohort Study

Kuriyama

Kakizaki

et al. 2010

Intl Journal of Cancer

View full text Add to dashboard Cite

An association between cholelithiasis and prostate cancer has been reported sporadically in previous case-control and experimental studies, suggesting that cholesterol may play a promotional role in prostate cancer development and progression. However, this relationship remains poorly understood, and population evidence based on a strict study design is needed. The authors examined the history of cholelithiasis and the development of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were ascertained among 22,458 Japanese men. Baseline information, including history of cholelithiasis, was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed that patients with a history of cholelithiasis had a higher risk of prostate cancer with a multivariate adjusted HR of 1.72 (95% CI: 1.12-2.66), and especially for advanced prostate cancer, the corresponding value was 2.29 (95% CI: 1.21-4.35). The associations were robust after adjustment for different potential confounders. This population-based prospective cohort study indicates that a history of cholelithiasis is associated with an increased incidence of prostate cancer.The incidence and mortality of prostate cancer has been increasing rapidly and is one of the major cancers affecting men, both in Japan and worldwide.1-4 However, its etiology and pathogenesis remain poorly understood.5 Previous studies have suggested that cholesterol may play a signal transduction role that promotes tumor cell growth during the development and progression of prostate cancer, 6 and that use of statin is associated with a decreased risk of advanced prostate cancer. 7 As cholelithiasis (gallstone disease) is related to cholesterol metabolism, it may further impact the carcinogenesis of prostate cells. Regarding the association between cholelithiasis and prostate cancer, one ecological study and one case-control study have been reported. 8,9 Both studies suggested such an association, but it needs to be further verified using a prospective designed study. Therefore, we examined the association between history of cholelithiasis and the risk of prostate cancer to further clarify this association using data from a population-based cohort study conducted in Japan. Material and Methods Study populationThe Ohsaki National Health Insurance (NHI) cohort study was a population-based prospective study conducted in Miyagi Prefecture, northeastern Japan. A detailed description of the design and methods is available elsewhere. [10][11][12] Briefly, all NHI beneficiaries aged 40-79 years living in the catchment area of the Ohsaki Public Health Center were involved in 1995, when baseline characteristics (such as basic information, history of cholelithiasis, and health-related lifestyle factors) were collected through a self-administered questionnaire. The Ohsaki Public Health Center, a local government agency, provi...

show abstract

Gallstone disease risk in relation to body mass index and waist-to-hip ratio in Japanese men

Cited by 32 publications

References 27 publications

Review article: gall‐bladder motor function in obesity

Review article: gall‐bladder motor function in obesity

Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China

History of cholelithiasis and the risk of prostate cancer: The Ohsaki Cohort Study

Contact Info

Product

Resources

About