Gallstone disease and mortality: a cohort study

Shabanzadeh, Daniel Mønsted; Sørensen, Lars Tue; Jørgensen, Torben

doi:10.1007/s00038-016-0916-7

Cited by 26 publications

(16 citation statements)

References 38 publications

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“…37 Gallstone disease has been linked to higher mortality and increased risks of major chronic diseases [e.g. metabolic syndrome, diabetes, cancer and cardiovascular disease (CVD) [38][39][40][41][42][43][44] ], indicating the possibility of shared pathways with other metabolic disorders. The mechanisms underlying SGD development are not well understood, but emerging evidence suggest an important role of insulin resistance, hyperinsulinemia and an unfavourable lipid profile such as hypertriglyceridemia or low concentrations of high-density lipoprotein (HDL) cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals

Wirth

Song

Fung

et al. 2018

International Journal of Epidemiology

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Objective: To investigate the association between three diet-quality scores corresponding to adherence to healthy dietary patterns [alternate Mediterranean (aMed), Alternate Healthy Eating Index (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH)] and the risk of symptomatic gallstone disease. Methods: The study comprised 43 635 men of the Health Professionals Follow-up Study-an ongoing prospective cohort study of US health professionals. Participants were free of symptomatic gallstone disease and diabetes and provided dietary information every 4 years from 1986 (baseline) until 2012. The aMed, AHEI-2010 and DASH scores were generated and associated with the risk of symptomatic gallstone disease using Cox proportional hazards regression. Results: During 716 904 person-years of follow-up, 2382 incident cases of symptomatic gallstone disease were identified. All three scores were inversely associated with risk of symptomatic gallstone disease after adjustment for potential confounders including age, smoking, physical activity, energy and coffee intake [hazard ratios (HRs) and 95% confidence intervals (CIs)] comparing the highest with the lowest quintiles: aMed

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Section: Discussionmentioning

confidence: 99%

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals

Wirth

Song

Fung

et al. 2018

International Journal of Epidemiology

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“…Studies on gallstone prevalence, incidence, mortality, and clinical follow-up have been published before. 26,[29][30][31][32][33][34] The explanatory variable was gallstone disease proven by ultrasound or cholecystectomy. Gallstones were defined as acoustic shadows that moved with gravity in the gallbladder lumen.…”

Section: Methodsmentioning

confidence: 99%

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

2017

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“…Gallstones are associated to cardiovascular mortality (Shabanzadeh et al ., ) and associations with cardiovascular disease risk factors have also been identified (Shabanzadeh et al ., ). An exploration of changes with age in cardiovascular risk factors and sex differences is therefore reasonable and would provide knowledge about gallstone disease and prevention.…”

Section: Introductionmentioning

confidence: 93%

Are incident gallstones associated to sex‐dependent changes with age? A cohort study

et al. 2017

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Age and female sex have repeatedly been identified as gallstone determinants but the underlying mechanisms are not clarified. The objectives of this study were to determine if changes with age in physiology, lifestyle, or reproductive hormones were associated with incident gallstones. A cohort study of a general population random sample (N = 2366) aged 30-60 years was performed. Participants were ultrasound screened for gallstones in 1982-84 and again in 1993-94. Lifestyle data and blood samples were obtained and re-analyzed in 2004. Changes with age in physiology (body mass index, blood pressure, blood lipids, self-rated health), lifestyle (smoking, alcohol and coffee consumption, dietary habits, physical activity level), and indices of reproductive function (number of births, oral contraceptive use, hormone replacement therapy, male reproductive hormones) were explored in females and males separately. Adjusted logistic regression analyses were performed. Incident gallstones (gallstones and cholecystectomy) at ultrasound examination in participants initially free of gallstones at baseline occurred in 9.9% of the study population. In females, increasing alcohol consumption (odds ratio (OR) 0.94, 95% confidence interval (CI) [0.90; 0.98]) and the cessation of hormone replacement therapy (OR 0.29, 95% CI [0.10; 0.83]) inversely determined incident gallstones. In males, increasing levels of SHBG (OR 0.97, 95% CI [0.94; 0.998]) inversely determined incident gallstones. Other changes with age in physiology, lifestyle, or reproductive hormones were not associated. High baseline free testosterone determined incident gallstones in males (OR 1.15, 95% CI [1.02; 1.30]). To conclude, changes with age in alcohol consumption in females and in reproductive hormones determined incident gallstones. Male reproductive hormones seem to have an impact on incident gallstones. Sex differences should be explored further in future studies.

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Gallstone disease and mortality: a cohort study

Abstract: Gallstone disease is associated with increased overall mortality and to death from cardiovascular disease. Gallstones may be considered a possible cardiometabolic risk factor. Other unknown factors also seem to play a role.

Cited by 26 publications

References 38 publications

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

Are incident gallstones associated to sex‐dependent changes with age? A cohort study

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