Gallstone Disease

Lammert, Frank; Dumoulin, Franz Ludwig; Sauerbruch, Tilman

doi:10.1002/9780470691861.ch19c

Cited by 2 publications

(7 citation statements)

References 154 publications

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“…8 There are several theories and proposed pathological mechanisms that explain why some patients have a single gallstone whereas others develop multiple gallstones. [9][10][11]20 Moreover, these pathological mechanisms are not limited to the gallbladder cavity/lumen alone but also extend to the surrounding anatomical structures. Hence, the number of gallstones could also influence the surgical outcome(s) of LC.…”

Section: Discussionmentioning

confidence: 99%

“…Gallstones irritate the mucosa, leading to mucosal hyperemia and transmural inflammation. 10,11,20 There is a release of cytokines, arachidonic metabolites, and oxygen free radicals from the macrophages. 10,11,20 Soon, a fibrin matrix is formed, which gradually matures into organized fibrous adhesions.…”

Section: Discussionmentioning

confidence: 99%

“…10,11,20 There is a release of cytokines, arachidonic metabolites, and oxygen free radicals from the macrophages. 10,11,20 Soon, a fibrin matrix is formed, which gradually matures into organized fibrous adhesions. 21 Vrako and Weichel have also observed the presence of periductal inflammation in the form of oedema, hyperemia, and petechiae on the outer surface of the bile duct in patients with asymptomatic CBD stones.…”

Section: Discussionmentioning

confidence: 99%

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Clinical presentation and surgical outcome among patients having single and multiple gallstones: a prospective study

Baghel¹,

Anand²,

Gupta³

2022

Int Surg J

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Background: Outcome of laparoscopic cholecystectomy is determined by an array of factors including patient & gallstone-related variables. Number of gallstones influences pathophysiology of disease thereby influencing outcome of surgery. This study was aimed at investigating clinical, haematological, radiological features and surgical outcomes among patients having single and multiple gallstones. Methods: Single centre, hospital-based, prospective, observational study involving 60 patients undergoing LC. Data pertaining to clinical, hematological, radiological variables and surgical outcomes were collected and analysed.Results: Mean duration of symptoms (m/c- pain) was significantly shorter among participants having multiple gallstones (p=0.034). There was no statistically significant difference among participants having single and multiple stones regarding any of clinical signs and symptoms (p>0.05). Mean GB wall thickness among patients having single and multiple gallstones was 3.27 mm and 4.18 mm (p=0.038). Difference in proportion of patients having pericholecystic collections was statistically significant (p=0.019). Mean duration of surgery among participants with single and multiple stones was 57 minutes and 71 minutes, respectively (p=0.012). On intraoperative examination, adhesion was noted in 20% of participants with single stone and 35% of participants in multiple stones group (p=0.029). Conversion rate to OC was 12% in multiple stones group and only 3.4% of participants with single stone (p=0.028). Adjusted odds ratio for conversion to OC was 3.39 (95% CI 1.98-7.89) for patients having multiple gallstones.Conclusions: Although patients having single and multiple gallstones have similar clinical features, findings of ultrasonography and surgical outcomes may differ significantly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical presentation and surgical outcome among patients having single and multiple gallstones: a prospective study

Baghel¹,

Anand²,

Gupta³

2022

Int Surg J

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“…Similar to adults, national data of hospitalization rates for children with gallstones between 1997 and 2009 revealed a 34% increase (6). An important difference between pediatric and adult gallstone disease is that non-obesity-related medical predispositions, such as congenital anomalies (eg, choledochal cyst) and hemoglobinopathies (eg, sickle cell disease), are more common in the pediatric age-range (1–3). However, given that studies demonstrate increasing pediatric obesity prevalence over time, the proportion of pediatric gallstone disease related to a non-obesity-related predisposition would be expected to decrease (7–10).…”

mentioning

confidence: 99%

“…G allstones (cholelithiasis; abnormal calcifications of bile) are common with an estimated lifetime prevalence of 16%. While most people with gallstones are asymptomatic, every year 2%-3% develop complications (common bile duct obstruction, gallstone pancreatitis, cholecystitis, cholangitis) requiring inpatient hospital care (1)(2)(3)(4). Hospitalizations for gallstones and their complications have increased significantly over time in adults.…”

mentioning

confidence: 99%

Pediatric Cholelithiasis in the United States: National Hospitalization Trends, 2006 to 2019

Agawu,

Kanagawa,

Wong

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Previous studies have shown increasing hospitalizations for pediatric cholelithiasis, but recent trends are unknown. We conducted a national study of pediatric cholelithiasis to characterize recent hospitalization rate trends. Methods: Retrospective repeated cross-sectional analysis of pediatric (age < 18) cholelithiasis-associated hospitalizations combining data from the 2006 through 2019 Kids Inpatient Database (KIDS) releases. The primary outcome of interest was the national hospitalization rate (per 100,000 children). We examined rates stratified by age group and sex and characterized hospitalization outcomes and characteristics for pediatric cholelithiasis. Results: 29,102 hospital records representing 42,282 gallstone-associated hospitalizations were identified. The hospitalization rate declined from 12.9 (95% CI: 12.6 – 13.2) in 2006 to 9.1 (95% CI: 8.8–9.3) in 2019. Consistent with the literature, hospitalizations occurred most often amongst teenagers (71%) and individuals with female sex (72%). The proportion of hospitalizations at freestanding children’s hospitals increased significantly (from 18.2% to 35.1%). Finally, the proportion of hospitalizations involving a potentially medical predisposing condition increased significantly. Conclusions: The estimated US hospitalization rate for pediatric cholelithiasis declined by 30% between 2006 and 2019. Female patients and teenagers had the largest decline, and hospitalizations increasingly occurred at freestanding children’s hospitals. Potential explanations include potential changes in delivery of care as well as changes in population disease burden.

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Gallstone Disease

Cited by 2 publications

References 154 publications

Clinical presentation and surgical outcome among patients having single and multiple gallstones: a prospective study

Clinical presentation and surgical outcome among patients having single and multiple gallstones: a prospective study

Pediatric Cholelithiasis in the United States: National Hospitalization Trends, 2006 to 2019

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