Gallstone Disease

Gurusamy, Kurinchi; Davidson, Brian R

doi:10.1002/9781119211419.ch22

Evidence‐based Gastroenterology and Hepatology 4e 2019

DOI: 10.1002/9781119211419.ch22

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Gallstone Disease

Kurinchi Gurusamy

Brian R Davidson

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2021

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“…For example, the Gastrointestinal Quality of Life Index (GQLI) measures quality of life using several domains relevant to people with gastrointestinal disorders, such as gallstones [ 4 ]. Surgical removal of the gallbladder (cholecystectomy, usually laparoscopic), is considered the most effective treatment for symptomatic gallstones [ 5 , 6 ], which can produce highly uncomfortable symptoms such as severe abdominal pain, nausea, bloating, and constipation [ 7 , 8 ]. English, German, Swedish, and Taiwanese versions of the GQLI have been validated for assessing the effects of gallstone disease and treatment on health-related quality of life (HRQoL) [ 4 , 9 – 11 ], and the instrument is widely used to compare patients’ gastrointestinal-related health status pre and post cholecystectomy [ 8 , 12 , 13 ].…”

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The minimally important difference of the Gastrointestinal Quality of Life Index for symptomatic gallstone surgery

et al. 2021

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Introduction The Gastrointestinal Quality of Life Index (GQLI) is used to measure domains of health and symptoms among people with gastrointestinal disorders. The objective of this study is to calculate the smallest change in the GQLI that is perceived by patients as meaningful among a sample of English-speaking adult patients undergoing elective laparoscopic cholecystectomy for treatment of symptomatic gallbladder disease. Materials and methods The study is based on retrospective analyses of a sample of participants completing the GQLI and the EQ-5D(3L) preoperatively and six months postoperatively in Vancouver, Canada. Patients are excluded if they are less than 19 years of age, cannot communicate in English, or reside in a long-term care facility. The MID is calculated for the GQLI’s domains using distribution and anchor-based methods. Results Among eligible patients, the participation rate was 51%. The estimated MID for the overall GQLI value ranged between 4.32 and 11.44. There were no statistically significant differences in the GQLI’s MID values between sexes or age subgroups. There were statistically significant differences in the GQLI’s MID values by baseline health status. Discussion This study should provide some comfort that the MID values used in discussing change in health and symptoms with elective cholecystectomy patients are robust to sex. Although the sample size may have been inadequate for age-based analyses, the study found large differences in MID values between age subgroups. Statistically significant differences in MID values based on preoperative health supports reporting MID values separately by baseline value. Further research should explore whether age-based differences in MID values exist using larger samples.

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The minimally important difference of the Gastrointestinal Quality of Life Index for symptomatic gallstone surgery

et al. 2021

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Gallstone Disease

Cited by 1 publication

References 99 publications

The minimally important difference of the Gastrointestinal Quality of Life Index for symptomatic gallstone surgery

The minimally important difference of the Gastrointestinal Quality of Life Index for symptomatic gallstone surgery

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