Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts

Gallotannin Imposes S Phase Arrest in Breast Cancer Cells and Suppresses the Growth of Triple-Negative Tumors In Vivo

“…Hence, even though loss of CcnD1 could contribute to the growth arrest observed in Gltn treated cells, it alone is unlikely to account for the S phase arrest observed in these cells. A previous study observed that the growth inhibition of colon cancer cells exposed to Gltn was associated with impaired NF-κβ activity [12]. In breast cancer cells, Gltn as a single agent does not impair NF-κβ activity, and actually a slight increase in NF-κβ binding was observed by gel mobility shift analysis (Fig.…”

“…Dietary Gltn reduced the frequency and number of both stomach and lung tumors in a carcinogen-induced mouse model of cancer [10]. Further studies have reported Gltn to have potent growth inhibitory properties against xenograft models of choliangiocarcinoma and colon cancer [11], [12]. Importantly, neither of these reports showed Gltn to generate discernible off-target toxicity in vivo .…”

BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway—A comparative study with curcumin

“…One important intracellular target in chemotherapy for cancer is NF-kB, a "rapid-acting" primary transcription factor that is a first responder to various cellular stimuli and which regulates expression of over 500 genes to influence inflammation, cell survival, invasion, angiogenesis and metastasis [30][31][32]. NF-kB plays a key role in the tumor progression of breast cancer, colon cancer and pancreatic cancer [33][34][35].…”

Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: role of the PI3K/AKT pathway and associated microRNAs

“…Gallic acid has been shown to have anti-metastasis effects through down-regulation of PI3K/AKT pathway and NF-B activity in gastric cancer cells [30]. In addition, it was reported that gallotannins possess cancer-cytotoxic properties via inhibition of NF-ĸB signaling in colon cancer cells [31] and AKT in lung cancer cells [32]. In our previous study, we reported the cytotoxic effect of pomegranate polyphenolics in BT474 breast cancer cells and nude mice with breast cancer cell xenografts by inhibiting NF-B activity and the PI3K/AKT pathway [20] as well as in HT-29 colon cancer cells and azoxymethane-injected rats by targeting the miR-126/PI3K(p85)/AKT axis [25].…”