Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock

Krecic‐Shepard, Mary Ellen; Shepard, Dale R.; Mullet, D.; Apseloff, Glen; Weisbrode, Steven E.; Gerber, Nicholas

doi:10.1016/s0024-3205(99)00375-6

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…In this regard, consistent with the current results, it was found that DMBA injected to rats lead to marked significant elevation in the levels of serum ALT and AST which are markers of hepatocellular damage (Bedi and Priyanka, 2012) .The elevation of these enzymes could be attributed to their release from the hepatocytes' cytoplasm to blood circulation upon rupture of the plasma membrane and cellular damage (Said, 2014). Our study revealed decrease in both ALT and AST enzyme activities with respect to DMBA-treated rats supporting that gallium has ameliorated hepatocellular injury and protected against necrosis (Krecic-Shepard, 1999). Also sodium ascorbate is considered a powerful hydro-soluble antioxidant capable of deoxidizing the reaction of oxygen and nitrogen free radical species.…”

Section: Resultssupporting

confidence: 73%

Biochemical effect of New Novel Composite on 7,12 dimethylbenz (a) anthracene Induced Mammary Carcinogenesis in Rats

Abouzaid

Badwi

Gabr

2017

Benha Veterinary Medical Journal

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Breast cancer is the second leading cause of cancer death in women, There are several ways to treat breast cancer .The effect of Lysine-Cetrimonium gallium Complex with zinc oxide nanopatricle and sodium ascorbate (NNC) on DMBA induced mammary carcinogenesis was investigated in female rats. Oral dose of DMBA induced a significant increase in ALT, AST, MDA and serum NO levels. On other hand marked depletion in CAT, GSH. On other hand oral administration of NNC was able to mitigate mammary carcinogenic damage induced by DMBA as evidence to pronounce curative effect against lipid peroxidation, serum NO level and deviated enzymatic variables and maintained glutathione status, antioxidant enzymes in addition histopathological changes directed toward control. We observed that the administration of (NNC) have potential to exert curative effects against mammary carcinogenesis.

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Section: Resultssupporting

confidence: 73%

Biochemical effect of New Novel Composite on 7,12 dimethylbenz (a) anthracene Induced Mammary Carcinogenesis in Rats

Abouzaid

Badwi

Gabr

2017

Benha Veterinary Medical Journal

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“…In the present study, we sought to investigate the effects of CH on acute lethal liver injury induced by lipopolysaccharide/D-galactosamine (LPS/D-GalN) and on acute peritonitis, a mild inflammatory response induced by zymosan A, both of which are well defined animal models [17][18][19][20][21]. LPS/D-GalN-induced acute lethal liver injury has been a widely used experimental animal model for more than 20 years, allowing both investigation of the mechanisms of lethal hepatic failure and development of effective therapeutic strategies against endotoxin challenge and sepsis in humans [22,23].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Yuan

Zheng

Xiao

et al. 2010

International Immunopharmacology

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“…2 Most relevant to COVID-19, gallium was found effective in a murine model of septic shock, in which it attenuated lipopolysaccharide-induced hepatitis and suppressed the production of nitric oxide, but had no effect on TNF-a production. 3 The hyperinflammatory reactions observed in severe cases of COVID-19 have many characteristics in common with septic shock. 4 Limited data have demonstrated antiviral activity of gallium against influenza A virus 5 and human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19

Bernstein¹,

Zhang

2020

Antivir Chem Chemother

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Background Gallium has demonstrated strong anti-inflammatory activity in numerous animal studies, and has also demonstrated direct antiviral activity against the influenza A H1N1 virus and the human immunodeficiency virus (HIV). Gallium maltolate (GaM), a small metal-organic coordination complex, has been tested in several Phase 1 clinical trials, in which no dose-limiting or other serious toxicity was reported, even at high daily oral doses for several months at a time. For these reasons, GaM may be considered a potential candidate to treat coronavirus disease 2019 (COVID-19), which is caused by the SARS-CoV-2 virus and can result in severe, sometimes lethal, inflammatory reactions. In this study, we assessed the ability of GaM to inhibit the replication of SARS-CoV-2 in a culture of Vero E6 cells. Methods The efficacy of GaM in inhibiting the replication of SARS-CoV-2 was determined in a screening assay using cultured Vero E6 cells. The cytotoxicity of GaM in uninfected cells was determined using the Cell Counting Kit-8 (CCK-8) colorimetric assay. Results The results showed that GaM inhibits viral replication in a dose-dependent manner, with the concentration that inhibits replication by 50% (EC50) being about 14 µM. No cytotoxicity was observed at concentrations up to at least 200 µM. Conclusion The in vitro activity of GaM against SARS-CoV-2, together with GaM’s known anti-inflammatory activity, provide justification for testing GaM in COVID-19 patients.

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Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock

Cited by 14 publications

References 34 publications

Biochemical effect of New Novel Composite on 7,12 dimethylbenz (a) anthracene Induced Mammary Carcinogenesis in Rats

Biochemical effect of New Novel Composite on 7,12 dimethylbenz (a) anthracene Induced Mammary Carcinogenesis in Rats

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19

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