Gallium maltolate shows synergism with cisplatin and activates nucleolar stress and ferroptosis in human breast carcinoma cells

Chen, Chieh-Hsin; Huang, Yiming; Grillet, Louis; Hsieh, Yi-Hsun; Yang, Yu‐Cih; Lo, Kai-Yin

doi:10.1007/s13402-023-00804-x

Cited by 2 publications

(1 citation statement)

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“…[53] Chen et al reported maltolate Ga III M (Gallium Maltolate) could increase the HO-1 and FTH1 level to induce ferroptosis (Figure 8). [54] Romani et al [55] investigated the anti-tumor mechanism of a Ga III (Q4) 3 . It could bind to DNA like Cisplatin, it could induce cell apoptosis through upregulating caspase 3 and p27 expression with meanwhile downregulated Bax and poly(ADP-ribose)polymerase (PARP) expression, or induce ferroptosis through disrupted intracellular redox homeostasis (downregulated GSH, GPX4, NADPH and activated NADPH-cytochrome P450 reductase).…”

Section: Gallium Complexesmentioning

confidence: 99%

Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti‐tumor Metallic complexes

Zhou,

Zhao,

Tao

et al. 2024

Chemistry An Asian Journal

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Metal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti‐tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti‐tumor process. It has been reported that metal complexes could inhibit the proliferation and metastasis of tumors and combat chemotherapy resistance by targeting ferroptosis. In this review, we briefly describe ferroptosis as a fundamental process for tumor suppression and triggering anti‐tumor immune responses. We summarize recent developments on metal complexes that induce ferroptosis. Finally, we outline the prospects for the application of metal complexes to the treatment of tumors based on ferroptosis and the associated problems that need to be solved, and discussed other potential research directions of metal complexes.

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Section: Gallium Complexesmentioning

confidence: 99%