Gallium (III)-acetate speciation studies under physiological conditions.

Hacht, Brahim

doi:10.23954/osj.v1i1.97

Cited by 8 publications

(7 citation statements)

References 21 publications

(28 reference statements)

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“…In the case of gallium, the existence of polynuclear species as opposed to mononuclear species has been described. Indeed, gallium(III) ions give rise to monomeric Ga(OH) 3 and Ga(OH) 4 − hydroxides together with polynuclear hydroxides such as Ga 3 (OH) 11 2− , Ga 4 (OH) 11 + and Ga 6 (OH) 15 3+ [ 73 , 74 ]. The tendency of Ga(III) to form polyionic hydroxides and the difficulty in determining mononuclear species seems to have been demonstrated.…”

Section: Resultsmentioning

confidence: 99%

“…Figure S2 shows the gallium distribution taking into account these hydrolysis phenomena. These polynuclear hydroxides, together with Ga(OH) 3 , have been termed colloidal solid gallium [ 73 , 75 , 76 ]. Since the predominant species in the pH range studied is Ga(OH) 3 , we assume that this must be the species retained on the surface, although we must also consider the possible adsorption of gallium in the form of positively charged polynuclear hydroxylated complexes.…”

Section: Resultsmentioning

confidence: 99%

“…The following supporting information can be downloaded at: , Figure S1: Zeta potential of ferrite particles synthetized as indicated in Experimental measured with dynamic light scattering (DLS); Figure S2: Distribution diagram of the hydrolysed forms of Ga(III) considering the polynuclear species (adapted from [ 73 ]); Figure S3: Distribution diagram for hydrolysed forms of In(III) (adapted from [ 86 ]); Figure S4: Dynamic Light Scattering (DSL) particle size distribution analysis obtained from ferrite particles synthetized as indicated in the work; Figure S5: FESEM image for Fe 3 O 4 and Figure S6: EDX spectra and atomic concentration tables corresponding to the area shows in Figure S5 for Fe 3 O 4 .…”

mentioning

confidence: 99%

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Using a Simple Magnetic Adsorbent for the Preconcentration and Determination of Ga(III) and In(III) by Electrothermal Atomic Absorption Spectrometry

et al. 2023

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A solid-phase dispersive microextraction procedure has been developed using ferrite (Fe3O4), an inexpensive magnetic material, as an adsorbent for the separation and subsequent determination of Ga(III) and In(III). The ions were removed from an aqueous solution by adsorption on Fe3O4, which was next easily collected from the medium by the action of a magnet. The analytes were then desorbed using 50 µL of 2 M NaOH or 50 µL of a 4:1 mixture of 0.1 M EDTA and 2 M HNO3 for the determination of Ga(III) or In(III), respectively. The level of the elements in the desorption phase was measured by electrothermal atomic absorption spectrometry (ETAAS) by injecting 10 µL of this phase into the atomizer. The enrichment factor was 163, and detection limits of 0.02 and 0.01 µg L−1 were achieved for Ga(III) and In(III), respectively. The reliability of the procedure has been verified by means of standard reference materials and by means of standard additions. Results are given for waters, soils and samples obtained from various electronic devices. It is of note that the procedure could be the basis for a useful way of recovering these valuable elements from different matrices for reuse.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Using a Simple Magnetic Adsorbent for the Preconcentration and Determination of Ga(III) and In(III) by Electrothermal Atomic Absorption Spectrometry

et al. 2023

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“…Thus, there are three patterns of acetate concentration influencing the labelling reaction yield. Gallium is known to form weak acetate complexes [28,29]. With logK = 3.7 [30], acetate is not able to compete with 9 for gallium binding.…”

Section: Radiolabelling and Stabilitymentioning

confidence: 99%

“…According to the calculations based on the obtained stability constants, the protonated complex GaH4L + of ligand 9 dominates in this pH range. Gallium is known to form weak acetate complexes [28,29]. With logK = 3.7 [30], acetate is not able to compete with 9 for gallium binding.…”

Section: Radiolabelling and Stabilitymentioning

confidence: 99%

Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for 68Ga Radiopharmaceuticals

et al. 2021

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Two new aminodiphosphonic acids derived from salicylic acid and its phosphonic analogue were prepared through a simple and efficient synthesis. 2-[(2-Amino-2,2-diphosphono)ethyloxy]-benzoic acid 8 and 2-[(2-amino-2,2-diphosphono)ethyloxy]-5-ethyl-phenylphosphonic acid 9 were evaluated for their applicability as 68Ga binding bone-seeking agents. Protonation constants of 8 and 9 and stability constants of the Ga3+ complexes with 8 and 9 in water were determined. The stability constant of Ga3+ complex with fully phosphorylated acid 9 (logKGaL = 31.92 ± 0.32) significantly exceeds stability constant of Ga3+ complex with 8 (logKGaL = 26.63 ± 0.24). Ligands 8 and 9 are as effective for Ga3+ cation binding as ethylenediamine-N,N’-diacetic-N,N’-bis(methy1enephosphonic) acid and ethylenediamine-N,N,N’,N’-tetrakis(methylenephosphonic) acid, respectively. The labelling process and stability of [68Ga]Ga-8 and [68Ga]Ga-9 were studied. Both 8 and 9 readily form 68Ga-complexes stable to ten-fold dilution with saline. However, in fetal bovine serum, only [68Ga]Ga-9 was stable enough to be subject to biological evaluation. It was injected into rats with bone pathology and aseptic inflammation of soft tissues. For [68Ga]Ga-9 in animals with a bone pathology model in 60 and 120 min after injection, a slight accumulation in the pathology site, stable blood percentage level, and moderate accumulation in the liver were observed. For animals with an aseptic inflammation, the accumulation of [68Ga]Ga-9 in the pathology site was higher than that in animals with bone pathology. Moreover, the accumulation of [68Ga]Ga-9 in inflammation sites was more stable than that for [68Ga]Ga-citrate. The percentage of [68Ga]Ga-9 in the blood decreased from 3.1% ID/g (60 min) to 1.5% ID/g (120 min). Accumulation in the liver was comparable to that obtained for [68Ga]Ga-citrate.

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HPLC method development using a mixed-mode column for following 68Ga-radiolabeling

Forgács

Jószai

Fekete

et al. 2023

J Radioanal Nucl Chem

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The aim of our work was to develop a generally applicable liquid chromatographic method for the determination of the residue free 68Ga3+ content of labeling reaction mixtures, in order to facilitate comparative labeling experiments in the early stages of chelator development. We achieved the retention of free 68Ga3+ on a mixed mode cation exchanger HPLC column with a gradient program, which allowed the separation from the non-retained complexes. The effects of reaction conditions (time, temperature) and the application of non-coordinating buffers were examined. Furthermore, recovery of free 68Ga3+ and these complexes were investigated, values of which were 94.9–97.4% and 87.4–99.6%.

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Gallium (III)-acetate speciation studies under physiological conditions.

Cited by 8 publications

References 21 publications

Using a Simple Magnetic Adsorbent for the Preconcentration and Determination of Ga(III) and In(III) by Electrothermal Atomic Absorption Spectrometry

Using a Simple Magnetic Adsorbent for the Preconcentration and Determination of Ga(III) and In(III) by Electrothermal Atomic Absorption Spectrometry

Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for 68Ga Radiopharmaceuticals

HPLC method development using a mixed-mode column for following 68Ga-radiolabeling

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