Gallium-67 scanning: Limited usefulness in staging patients with non-Hodgkin's lymphoma

Longo, Dan L.; Schilsky, Richard L.; Blei, Lynne; Cano, Roque; Johnston, Gerald S.; Young, Robert C.

doi:10.1016/0002-9343(80)90256-9

Cited by 28 publications

(3 citation statements)

References 6 publications

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“…Gallium citrat (Ga-67) scintigraphy has an important role in monitoring patients' response to treatment and in detecting residual active lymphoma, especially in the mediastinum (1)(2)(3)(4)(5)(6)(7)(8). The current role of Ga-67 scintigraphy as part of staging work-up remains controversial, because sensitivity is decreased especially in the abdomen owing to hepatic uptake and excretion into the bowel (9)(10)(11). The specificity of Ga-67 scintigraphy is also limited because of uptake by normal tissue, especially in the pulmonary hila (5,(12)(13)(14)(15).…”

Section: Original Articlementioning

confidence: 99%

Positron Emission Tomography with 18-Fluorodeoxyglucose in the Staging and Follow-up of Lymphoma in the Chest

Bangerter

1999

Acta Oncologica

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Section: Original Articlementioning

confidence: 99%

Positron Emission Tomography with 18-Fluorodeoxyglucose in the Staging and Follow-up of Lymphoma in the Chest

Bangerter

1999

Acta Oncologica

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“…These include the chest X-ray, computed tomography (CT), lymphangiography (although now less frequently applied), ultrasound, and magnetic resonance imaging (MRI). Due to the above-mentioned negative outcomes of earlier reports, 67 Ga scintigraphy has not played an important role in the management of patients with lymphoma [15,16]. The anatomical resolution of CT and MRI is far superior to that of nuclear medicine imaging methods, which implies that the former modalities are better suited for the precise localization of pathological masses.…”

Section: Ga Scintigraphy Prior To Treatmentmentioning

confidence: 99%

Role of 67 Ga scintigraphy in localization of lymphoma

Amsterdam

Kluin-Nelemans

Eck-Smit

et al. 1996

Annals of Hematology

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This review deals with the applications of 67Gallium (Ga) scintigraphy for the initial staging and follow-up during and after treatment of patients with Hodgkin's or non-Hodgkin's lymphoma (NHL). During the last decade, the technique of visualization has been largely improved by using higher doses and additional tomography. Here, the indications for 67Ga scintigraphy in comparison with CT and MRI are discussed. The conditions resulting in false positive and false negative results have been outlined. 67Ga may detect unusual involved sites during staging procedures. However, the major contribution to the management of Hodgkin's disease and NHL is the evaluation of residual masses, because 67Ga uptake reflects the metabolic activity of the tumor. The review ends with an additional short overview of other radionuclide imaging methods useful for malignant lymphoma.

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“…Insgesamt folgern wir, daß die Bestimmung der 6 7 Ga-Kinetik im Blut wenig klinisch relevante Informationen über Vorhandensein, Größe und Wachstumsrate von malignen Tumoren beim Menschen liefert. 6 7 Gallium is widely used for tumor imaging (6,10,13,16,23), but clinical reliability is limited to specific indications (1,11,15,21). Knowledge about gallium kinetics in man is still incomplete.…”

Section: Die 67 Ga-kinetik Im Blut Bei Patienten Mit Malignen Tumorenunclassified

67Gallium Kinetics in the Blood of Patients with Malignant Tumors

Keller¹,

Mk²,

Koeppe³

1983

Nuklearmedizin

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67GaIlium was injected into 60 patients with malignant tumors and into 42 patients in whom malignant tumors had been excluded by clinical investigation. 67Ga kinetics in blood were evaluated by non-linear least square regression computer analysis according to an open 2-compartment model where elimination proceeds from the peripheral compartment. Parameters of 67Ga kinetics in tumor patients showed a bimodal distribution, as was also the case in patients without tumors. No difference could be demonstrated between kinetic parameters of tumor patients and patients without tumors. In 4 patients, 67Ga kinetics could be evaluated before and after treatment of their malignant tumors, but a decrease in the volume of distribution was the single alteration of kinetic parameters occurring after treatment. This decrease may be explained by a smaller peripheral compartment resulting from the loss of tumor mass after treatment. Nevertheless, we conclude that the evaluation of 67Ga kinetics in blood will provide only limited information about the presence, size and growth rate of malignant tumors in man.

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Gallium-67 scanning: Limited usefulness in staging patients with non-Hodgkin's lymphoma

Cited by 28 publications

References 6 publications

Positron Emission Tomography with 18-Fluorodeoxyglucose in the Staging and Follow-up of Lymphoma in the Chest

Positron Emission Tomography with 18-Fluorodeoxyglucose in the Staging and Follow-up of Lymphoma in the Chest

Role of 67 Ga scintigraphy in localization of lymphoma

67Gallium Kinetics in the Blood of Patients with Malignant Tumors

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