Gallium-67 imaging in the diagnosis of blastomycosis

Giorgi, Maria Clementina Pinto; Camargo, Edwaldo E.; Pinto, Walkyria Pereira; Negro, G. Del

doi:10.1007/bf00256555

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…Table 2 presents the frequency of organic involvement (117,318), bone destruction, vascular system pathology, and even genital lesions (8,54). Scans making use of gallium-67 frequently reveal lesions that were not suspected clinically or radiologically (42,122).…”

Section: Infectionmentioning

confidence: 99%

Paracoccidioidomycosis: an update

1993

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This review summarizes knowledge on various aspects of paracoccidioidomycosis. Mycelial propagules, chlamydospores, and arthroconidia exhibit thermal dimorphism; arthroconidia are infectious in animals and, by electron microscopy, appear well provided for survival. The mycelial-to-yeast-phase transformation requires a strict control of glucan synthesis probably mediated by membrane enzymes. Hormonal influences on the transformation of the fungus (mycelium or conidium to yeast phase) have been demonstrated. Estrogen-binding proteins have been detected in the fungal cytosol, and during the transformation novel proteins are produced as a result of estradiol incorporation. Clinical forms have been better defined on the basis of better experimental models. Emphasis has been placed on the lungs as the portal of entry and on the existence of silent pulmonary infections. A specific Paracoccidioides brasiliensis antigen, the 43-kDa glycoprotein (Gp43), has been identified, characterized, and cloned. This has led to improved reproducibility and specificity of serologic tests. The depression of cell-mediated immune responses has been associated with severe disease in humans and in the experimental host. T-cell subsets in patients' tissues were characterized by means of monoclonal antibodies, and a reduced CD4/CD8 ratio was demonstrated. This has been related to alterations in lymphokine and tumor necrosis factor production, production of antigen-antibody complexes, etc. Amphotericin B has provided effective therapy. Azole derivatives have also improved prognosis and facilitated therapy. Itraconazole is presently the drug of choice, yet incapacitating sequelae (mainly pulmonary fibrosis) still constitute major problems.

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Section: Infectionmentioning

confidence: 99%

Paracoccidioidomycosis: an update

1993

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“…The use of gallium-67 scans in patients with paracoccidioidomycosis and other mycosis has already been described [5][6][7]9 . GIORGI et al 9 , studying 13 patients with confirmed diagnosis of paracoccidioidomycosis, have shown that whole body gallium-67 imaging is a useful tool for detection of suspected and unsuspected lesions of paracoccidioidomycosis and helps to evaluate the response of the disease to specific therapy.…”

Section: Commentsmentioning

confidence: 99%

“…GIORGI et al 9 , studying 13 patients with confirmed diagnosis of paracoccidioidomycosis, have shown that whole body gallium-67 imaging is a useful tool for detection of suspected and unsuspected lesions of paracoccidioidomycosis and helps to evaluate the response of the disease to specific therapy. These authors have shown good correlation between whole body gallium-67 scintigraphy and the clinical and laboratory findings.…”

Section: Commentsmentioning

confidence: 99%

Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report

Teixeira

Etchebehere

Lima

et al. 2000

Rev. Inst. Med. trop. S. Paulo

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“…For example, Giorgi MCP, et al have shown that all lesions of South American blastomycosis in 13 cases could be detected by whole body Ga-67 scintigraphy. 6 But its application in the detection of chromomycosis has not been reported yet.…”

Section: Case Reportmentioning

confidence: 99%

Ga-67 scintigraphy in chromomycosis

et al. 1989

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We examined an interesting case of chromomycosis that had a characteristic Ga-67 accumulation. This patient had had widespread chromomycosis skin lesions for 8 years. We performed Ga-67 scintigraphy in an attempt to obtain additional information on the site and extent of the lesion. Ga-67 scintigraphy revealed not only all subcutaneous nodules but also an unsuspected enlarged lymphnode and a visceral lesion. This case indicates that Ga-67 scintigraphy is a very useful method to use in detecting the site and extension of chromomycosis, especially in the nodal and the visceral lesions, and sometimes might help in differential diagnosis.

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Gallium-67 imaging in the diagnosis of blastomycosis

Cited by 14 publications

References 10 publications

Paracoccidioidomycosis: an update

Paracoccidioidomycosis: an update

Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report

Ga-67 scintigraphy in chromomycosis

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