Gallium-67 Citrate Scan in Extrapulmonary Tuberculosis

Lin, Wan‐Yu; Hsieh, Jih-Fang

doi:10.1055/s-0038-1632211

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Gallium-67 citrate, Indium-111-labeled autologous leukocyte (white blood cell) scintigraphy, and fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful in the setting of pyrexia of unknown origin, in which tuberculosis is implicated and no definitive source has been identified with other imaging techniques. In one study, Ga-67 scintigraphy had a sensitivity of 78% in identifying extrapulmonary tuberculosis but failed to help diagnose any cases of tuberculous meningitis (17). When the differential diagnosis includes skeletal infection, technetium-99m methylene diphosphonate bone scintigraphy can help localize focal sepsis and is about as sensitive as In-111 white blood cell scintigraphy (18).…”

Section: Nuclear Imagingmentioning

confidence: 99%

Tuberculosis: A Radiologic Review

Burrill¹,

Williams²,

Bain³

et al. 2007

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Tuberculosis has shown a resurgence in nonendemic populations in recent years, a phenomenon that has been attributed to factors such as increased migration and the human immunodeficiency virus epidemic. Although the thorax is most frequently involved, tuberculosis may involve any of a number of organ systems (eg, the respiratory, cardiac, central nervous, musculoskeletal, gastrointestinal, and genitourinary systems), and timely diagnosis of the disease is paramount, since delayed treatment is associated with severe morbidity. Unfortunately, a history of infection with or exposure to tuberculosis may or may not be present, and evidence of active tuberculosis is present in less than 50% of cases. A negative tuberculin skin test does not in itself exclude infection. Furthermore, the clinical and radiologic features of tuberculosis may mimic those of many other diseases. Therefore, although in many cases biopsy or culture specimens are required to make the definitive diagnosis, it is imperative that radiologists and clinicians understand the typical distribution, patterns, and imaging manifestations of tuberculosis.

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Section: Nuclear Imagingmentioning

confidence: 99%

Tuberculosis: A Radiologic Review

Burrill¹,

Williams²,

Bain³

et al. 2007

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361

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“…Some studies have demonstrated the value of 67 Ga imaging in the evaluation of disease extent in extrapulmonary tuberculosis, and lymphatic and respiratory infections in immunocompromised patients [2,3,12,13]. The few false negative results occurred in patients with cervical tuberculous lymphadenopathy [12].…”

Section: Discussionmentioning

confidence: 99%

“…Gallium-67 imaging has been successfully used to evaluate multifocal involvement in potentially disseminated infectious diseases such as tuberculosis, coccidioidomycosis and AIDS-related infections [2,3,4]. Two previous studies with small cohorts of patients have similarly suggested its utility in PCM [5,6].…”

Section: Introductionmentioning

confidence: 97%

The role of gallium-67 scan in defining the extent of disease in an endemic deep mycosis, paracoccidioidomycosis: a predominantly multifocal disease

Yamaga

Benard

Hironaka

et al. 2003

Eur J Nucl Med Mol Imaging

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The tools currently used to evaluate the extent of paracoccidioidomycosis (PCM) may be of limited value in detecting subclinical lesions. The aim of this study was to verify the role of gallium-67 whole-body scan in evaluating the extent of disease of 65 patients with active PCM. The (67)Ga scan findings were compared with the results of clinical evaluation, chest radiography and/or high-resolution computed tomography (CT), abdominal ultrasound (US) or CT, laryngoscopy, CT or magnetic resonance imaging (MRI) of the head, and technetium-99m methylene diphosphonate bone scan, obtained before treatment. Clinically unsuspected lesions were detected by imaging procedures in 21 patients (32%), mainly in the lungs (n=11), adrenals (n=6), and superficial (n=3) and deep lymph nodes (n=14). (67)Ga scan detected 100% of the cases with subclinical involvement in the lungs. Scintigraphy was superior to chest radiography in demonstrating lung disease (94% vs 81%). The lymphatic lesions were demonstrated by (67)Ga scan in all the clinically suspected cases and in nearly all unsuspected cases, and also revealed more extensive involvement than was clinically suspected in many of them. There was good agreement between (67)Ga scan and the other imaging procedures for the initial detection of thoracic and abdominal lymph nodes and bone involvement. (67)Ga imaging detected most cases of laryngopharyngeal disease with active inflammatory lesions found at indirect laryngoscopy. On the other hand, (67)Ga scan failed to demonstrate most of the adrenal and CNS lesions detected by abdominal US/CT and head CT/MRI. In conclusion, (67)Ga imaging is a useful tool for evaluating the location and extent of suspected and unsuspected lesions in PCM. It could serve as a screening method before the use of other diagnostic procedures, particularly in the detection of lung, superficial and deep lymph node and bone involvement.

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Other Diseases Caused by Bacteriae

Braga¹

2002

Nuclear Medicine in Tropical and Infectious Diseases

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Gallium-67 Citrate Scan in Extrapulmonary Tuberculosis

Cited by 6 publications

References 10 publications

Tuberculosis: A Radiologic Review

Tuberculosis: A Radiologic Review

The role of gallium-67 scan in defining the extent of disease in an endemic deep mycosis, paracoccidioidomycosis: a predominantly multifocal disease

Other Diseases Caused by Bacteriae

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