Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats

Sohrabi, Farzaneh; Dianat, Mahin; Badavi, Mohammad; Radan, Maryam; Mard, Seyyed Ali

doi:10.1007/s11356-021-14513-1

Cited by 38 publications

(21 citation statements)

References 58 publications

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“…To date, adequate evidence exists to support the antioxidation, anti-inflammatory, and antimicrobial activities of GA (45,63,64). In this study, we summarized the results of 16S rRNA gene sequencing metabolomics analysis and discussed the effects of environmental stress and GA on the host-microbial metabolic axis from the relationship between metabolic biomarkers and gut bacteria.…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

et al. 2022

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Early-life exposure to environmental stress disrupts the gut barrier and leads to inflammatory responses and changes in gut microbiota composition. Gallic acid (GA), a natural plant polyphenol, has received significant interest for its antioxidant, anti-inflammatory, and antimicrobial properties that support the maintenance of intestinal health. To assess whether dietary supplementation of GA alleviates environmental stress, a total of 19 puppies were randomly allocated to the following three dietary treatments for 2 weeks: 1) basal diet (control (CON)); 2) basal diet + transportation (TS); and 3) basal diet with the addition of 500 mg/kg of GA + transportation (TS+GA). After a 1-week supplementation period, puppies in the TS and TS+GA groups were transported from a stressful environment to another livable location, and puppies in the CON group were then left in the stressful environment. Results indicated that GA markedly reduced the diarrhea rate in puppies throughout the trial period and caused a moderate decline of serum cortisol and HSP-70 levels after transportation. Also, GA alleviated the oxidative stress and inflammatory response caused by multiple environmental stressors. Meanwhile, puppies fed GA had a higher abundance of fecal Firmicutes and Lactobacillus and lower Proteobacteria, Escherichia–Shigella, and Clostridium_sensu_stricto_1 after transportation. As a result, the TS+GA group had the highest total short-chain fatty acids and acetic acid. Also, the fecal and serum metabolomics analyses revealed that GA markedly reversed the abnormalities of amino acid metabolism, lipid metabolism, carbohydrate metabolism, and nucleotide metabolism caused by stresses. Finally, Spearman’s correlation analysis was carried out to explore the comprehensive microbiota and metabolite relationships. Overall, dietary supplementation of GA alleviates oxidative stress and inflammatory response in stressed puppies by causing beneficial shifts on gut microbiota and metabolites that may support gut and host health.

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Section: Discussionmentioning

confidence: 99%

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

et al. 2022

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“…As a phenolic compound, gallic acid has a variety of biological and pharmacological activities. More and more studies have confirmed that gallic acid provides significant protection against T2DM-mediated liver injury [ 227 ], and modulates the Nrf2 signaling pathway to protect the lungs against emphysema [ 228 ]. Gallic acid protects the cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction [ 229 ].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Chen

Zhang

Lin

et al. 2022

IJMS

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Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories. The phrase “secondary mitochondrial diseases” essentially refers to any abnormal mitochondrial function other than primary mitochondrial diseases, i.e., the process caused by the genes encoding the electron transport chain (ETC) proteins directly or impacting the production of the machinery needed for ETC. Mitochondrial diseases can cause adenosine triphosphate (ATP) synthesis disorder, an increase in oxygen free radicals, and intracellular redox imbalance. It can also induce apoptosis and, eventually, multi-system damage, which leads to neurodegenerative disease. The catechin compounds rich in tea have attracted much attention due to their effective antioxidant activity. Catechins, especially acetylated catechins such as epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), are able to protect mitochondria from reactive oxygen species. This review focuses on the role of catechins in regulating cell homeostasis, in which catechins act as a free radical scavenger and metal ion chelator, their protective mechanism on mitochondria, and the protective effect of catechins on mitochondrial deoxyribonucleic acid (DNA). This review highlights catechins and their effects on mitochondrial functional metabolic networks: regulating mitochondrial function and biogenesis, improving insulin resistance, regulating intracellular calcium homeostasis, and regulating epigenetic processes. Finally, the indirect beneficial effects of catechins on mitochondrial diseases are also illustrated by the warburg and the apoptosis effect. Some possible mechanisms are shown graphically. In addition, the bioavailability of catechins and peracetylated-catechins, free radical scavenging activity, mitochondrial activation ability of the high-molecular-weight polyphenol, and the mitochondrial activation factor were also discussed.

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“…HO-1, as a cytoprotective protein with antioxidant properties, takes part in many chronic diseases by regulating in ammation and cell death [27][28][29]. Activating Nrf2/HO-1 signal pathway might be a bene cial factor for COPD [30,31].…”

Section: Dach1 Mitigated In Ammation Induced By Cse In 16hbe Cellsmentioning

confidence: 99%

Dach1 attenuates airway inflammation in chronic obstructive pulmonary disease by activating Nrf2 signaling

Huang

et al. 2022

Preprint

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Background: Chronic obstructive pulmonary disease (COPD)is a small airway chronic inflammatory disease with impaired lung function primarily induced by cigarette smoke (CS). Reduced Dach1 expression has a vicious role in numerous disorders. but its role in COPD is rarely known. This study aims to elucidate the role and underlying mechanism of Dach1 in airway inflammation of COPD. Methods:Dach1 expression in lung tissues of COPD patients has been calculated. Small airway epithelium-specific Dach1 knockdown mice and AAV-transfected Dach1 overexpressed mice were used to explore its role and potential for therapeutic targeting in experimental COPD induced by CS. Furtherly, we uncovered the promising mechanism of Dach1 in inflammation induced by cigarette smoke extract simulation (CSE) in vitro. Results:The expression of Dach1 decreased in COPD patients compared to non-smokers and smoker without COPD, especially in small airway epithelium. Small airway epithelium-specific Dach1 knockdown aggravated mice airway inflammation and lung function decline caused by CS, while Dach1 overexpression protected mice from airway inflammation and lung function decline. In 16 HBE cells, Dach1 knockdown and overexpression promoted and inhibited the secretion of IL-6 and IL-8 after simulation of CSE, respectively. Nuclear factor erythroid 2-related factor 2 (Nrf2) was identified as novel downstream target of Dach1, which directly binds to its promoter. Induction of Dach1 alleviated inflammation by activating Nrf2 signaling. Conclusions: Dach1 is decreased in COPD patients. Dach1 has protective effects against inflammation induced by CS by activating Nrf2 signaling pathway. Targeting Dach1 is a potential therapeutic strategy for COPD.

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Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats

Cited by 38 publications

References 58 publications

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Dach1 attenuates airway inflammation in chronic obstructive pulmonary disease by activating Nrf2 signaling

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