Abstract:Objectives: This study aimed to investigate the protective effect of gallic acid (GA) against cyclophosphamide (CYP)induced lung toxicity with exploring the mechanism of CYP cytotoxicity using normal human lung cells, WI-38 cell line. Methods: WI-38 cells have been categorized into three groups; first group was considered as control, untreated, cells; CYP-group, cells were treated with IC50 concentration of CYP for 24 h; GA+CYP group, cells were pretreated with a selected dose of GA for 24 h then followed by C… Show more
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