Gallic acid protects against neurochemical alterations in transgenic Drosophila model of Alzheimer’s disease

Ogunsuyi, Opeyemi B.; Oboh, Ganiyu; Oluokun, Odunayo O.; Ademiluyi, Adedayo O.; Ogunruku, Omodesola O.

doi:10.1007/s13596-019-00393-x

Cited by 37 publications

(36 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…D. melanogaster (wild type; Oregon strain) stock culture from the National Species Stock Centre (Bowling Green, OH, USA) was used. The flies were raised on standard fly medium as previously described (Ogunsuyi, Oboh, Oluokun, Ademiluyi, & Ogunruku, 2019).…”

Section: Methodsmentioning

confidence: 99%

“…In this assay, 50 µl of tissue homogenate was added to 150 µl of 8.1% sodium dodecyl sulfate (SDS), 0.27 M HCL with 75.6 ml/L of acetic acid (pH 3.4), and 14.57 mM of thiobarbituric acid (TBA), followed by 1‐hr incubation at 100°C. The thiobarbituric acid reactive substance (TBARS) generated was determined at 532 nm and expressed as malondialdehyde (MDA) equivalent (Ohakawa, Ohishi, & Yagi, 1979; Ogunsuyi et al, 2019).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

et al. 2020

Self Cite

View full text Add to dashboard Cite

The pathogenesis of several neurodegenerative diseases have been identified to be both genetic and sporadic; considering the latter, environmental risk factors are very prominent. One of the most ubiquitous element in the environment is aluminum (Al), valuable for producing various domestic and industrial products for human uses (Bayliak et al., 2019; Liu et al., 2018). Physiologically, Al is a nonessential metal and excessive exposure to it has been

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Flies (transgenic and wild type) were obtained from University of Drexel, Philadelphia, USA, and were raised on the standard culture medium as previously described by Ogunsuyi et al. (2019) and Oboh et al (2020).…”

Section: Methodsmentioning

confidence: 99%

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

et al. 2020

Self Cite

View full text Add to dashboard Cite

Much emphasis has been placed on the biological activities of citrus peel's essential oils (CPEOs) against human ailments. This study investigated the effect of Citrus limon and Citrus reticulata peel's essential oils (EOs) on behavioral and neurochemical imbalance in transgenic and Harwish (Wild) fruit flies. Flies were divided into seven groups comprising of the control and those that were fed with 0.1, 0.5, and 1.0 µg/ ml of the dietary inclusions of study CPEOs for 7 days. Thereafter, behavioral profile was examined using lethality response and negative geotaxis assays. Effect of the EOs on cholinesterase and monoamine oxidase (MAO) activities, and antioxidative parameters were determined. The result showed a significant improvement of behavioral pattern and biochemical parameters of the flies fed with studied CPEOs inclusive diets. Conclusively, both EOs exert neuroprotective capability by reducing cholinesterases and monoamine activities, and also prevent oxidative stress, which are implicated in neuronal dysfunction in humans. Practical applications With the growing increase in the search for safer alternatives, having no side effects, for the management of neurodegenerative diseases, a large proportion of the populace is beginning to find solace in the use of natural products. Also, the wide array of similarities between the humans and the dipteran insects, fruit flies is a perfect organism for the study of neurodegenerative diseases. Therefore, this study presents the neuroprotective potentials of lemon and tangerine peels-derived EOs, and the possibility of their exploration as neuroactive agents and alternative in the management of Alzheimer's disease (AD).

show abstract

“…Aversive phototaxis Suppression assay described earlier by Ogunsuyi et al. (2020) was used to measure memory. The ability of the flies transferred into the dark chamber of a T‐maze to correlate the bitter taste of quinine to light sensitivity at zero hour (0 hr) and 6 hr (6 hr) was recorded as average pass rate and expressed as the successful avoidance percent of trials per total trials to depict memory index.…”

Section: Methodsmentioning

confidence: 99%

“…Monoamine oxidase (MAO) activity was evaluated as previously reported by Ogunsuyi et al. (2020), with little modifications. The reaction consist of 0.025 M phosphate buffer (pH 7.0), 0.0125 M semicarbazide, 10 mM benzylamine, and tissue homogenate.…”

Section: Methodsmentioning

confidence: 99%

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

et al. 2021

Self Cite

View full text Add to dashboard Cite

This study sought to determine the life span promoting effecof orange (Citrus sinensis), tangerine (Citrus maxima) and grapefruit (Citrus paradisi) peels in Drosophila melanogaster model. Flies (both gender, 3 to 5 days old) were divided into seven (7) groups (n = 5) containing 40 flies each; group I (control) flies were fed with basal diet, II-VII were flies were fed with basal diet containing 0.1 and 1.0% of tangerine peel (TP), orange peel (CP), and grapefruit peel (GP) respectively, for 14 days. Locomotor performance and memory index were assessed via negative geotaxis and aversive phototaxis suppression assays, respectively. Thereafter, the fly homogenates were assayed for activities of acetylcholinesterase (AChE), monoamine oxidase (MAO) and antioxidant enzymes as well as other indices of their redox. The results revealed that the citrus peels significantly improved longevity, locomotor performance, memory index, antioxidant status, and modulate cholinesterase and monoamine oxidase enzyme activities in treated flies when compared to the control. The results obtained suggest that the citrus peels offer potentials as dietary supplement with life span promoting properties in D. melanogaster model which could as well serve as a functional food additives. Practical applications Citrus peels, although often considered agro-wastes, are used as food supplements and food ingredents especially in production of candies, jams and custards. This study suggests the use of orange (Citrus sinensis), tangerine (Citrus maxima), and grapefruit (Citrus paradisi) peels as dietary supplements which offers potential life span promoting properties.

show abstract

Gallic acid protects against neurochemical alterations in transgenic Drosophila model of Alzheimer’s disease

Cited by 37 publications

References 57 publications

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

Contact Info

Product

Resources

About