Gallic acid grafting to a ferrimagnetic bioactive glass-ceramic

Ferraris, Sara; Zhang, Xin; Prenesti, Enrico; Corazzari, Ingrid; Turci, Francesco; Tomatis, Maura; Verné, Enrica

doi:10.1016/j.jnoncrysol.2015.05.023

Cited by 28 publications

(29 citation statements)

References 42 publications

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“…As far as the signal at 284.81 eV is concerned, C-C and C-H bonds are typical of the above-cited hydrocarbon contamination but are also present within the GA molecule. The presence of C-O and C=O can be associated with the presence of GA and to its tendency (phenol groups) to oxidize into quinone, as previously observed by the authors [29,30].…”

Section: Biomolecule Detectionsupporting

confidence: 72%

“…In the case of the samples functionalized in a source solution with PBS as medium, the lower amount of OH groups can be related both to a reduced amount of grafted biomolecule and to a different orientation on the surface. The growth of the OH peak after gallic acid functionalization was already observed by the authors on the functionalized bioactive glasses [29,30]. Since functionalization starting from source solutions with SBF as medium gave the best results in terms of amount and activity of grafted GA and that no highly significant (p < 0.05) differences were detected between the two tested concentrations, further analyses were performed only on the CT_GA_SBF_1 samples and on the CT samples as reference.…”

Section: Biomolecule Detectionmentioning

confidence: 74%

“…The F&C test measures the redox reactivity of phenolic substances and give a quantification of their amount using a calibration curve obtained with GA as standard [29]. The test was performed on the source solution (before and after functionalization) and on the functionalized samples as reported in previous works [29,30,46]. This analysis was performed in triplicate and statistical analysis was obtained through ANOVA one-way test (p < 0.05).…”

Section: Detection Of the Grafted Biomoleculementioning

confidence: 99%

“…In order to allow the binding of a significant amount of biomolecules to the surface, the protocol of functionalization used in this research was developed from previous works of the authors [29,30] and from literature data [28]. The previous works of the authors concern surface functionalization of bioactive glasses and glass ceramics.…”

Section: Ph Measurementsmentioning

confidence: 99%

“…Few researches considered inorganic materials as substrates for functionalization: Extract of Gusuibu (Drynaria roosii) was covalently linked to calcium hydrogen phosphate [27]; natural polyphenols and pyrogallol were used as coating on stainless steel [28]. Silica-based bioactive glasses and glass ceramics were successfully functionalized with gallic acid and natural extracts from red grape skins and green tea leaves by the authors, as reported in previous papers [29,30].…”

Section: Introductionmentioning

confidence: 97%

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Grafting of Gallic Acid onto a Bioactive Ti6Al4V Alloy: A Physico-Chemical Characterization

et al. 2019

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Despite increasing interest in the use of natural biomolecules for different applications, few attempts of coupling them to inorganic biomaterials are reported in literature. Functionalization of metal implants with natural biomolecules could allow a local action, overcoming the issue of low bioavailability through systemic administration. In the present work, gallic acid was grafted to a pre-treated Ti6Al4V in order to improve its biological response in bone contact applications. The grafting procedure was optimized by choosing the concentration of gallic acid (1 mg/mL) and the solvent of the solution, which was used as a source for functionalization, in order to maximize the amount of the grafted molecule on the titanium substrate. The functionalized surfaces were characterized. The results showed that functionalization with Simulated Body Fluid (SBF) as solvent medium was the most effective in terms of the amount and activity of the grafted biomolecule.A key role of calcium ions in the grafting mechanism is suggested, involving the formation of coordination compounds formed by way of gallic acid carboxylate and Ti-O − as oxygenated donor groups. Bioactive behavior and surface charge of the pre-treated Ti6Al4V surface were conserved after functionalization. The functionalized surface exposed a greater amount of OH groups and showed higher wettability.

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Section: Biomolecule Detectionsupporting

confidence: 72%

Section: Biomolecule Detectionmentioning

confidence: 74%

Section: Detection Of the Grafted Biomoleculementioning

confidence: 99%

Section: Ph Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Grafting of Gallic Acid onto a Bioactive Ti6Al4V Alloy: A Physico-Chemical Characterization

et al. 2019

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A Multifunctional Coating Strategy for Promotion of Immunomodulatory and Osteo/Angio‐Genic Activity

Xiao

Wei

Jin

et al. 2022

Adv Funct Materials

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Building of multifunctional coatings in a more effective way is crucial for meeting the multilevel requirements of regenerative medicine. Herein, inspired by diatom and mussel, a specific but universal approach is proposed for building multifunctional coatings on slow‐degradable and fast‐degradable scaffolds or various substrates by using epigallocatechin gallate (EGCG) and polyethyleneimine (PEI) as bridges of silicon coupling. The results reveal that the polyphenol EGCG facilitates silica precipitation and coating topological morphology in synergy with PEI, and realizes antioxidant and immunomodulatory effects. The introduction of EGCG and the release of silicon ions present effective modulation of the immune microenvironment and remarkable promotion of angiogenesis and osteogenesis. The EGCG/silica coating strategy demonstrates a promising perspective for designing multifunctional coatings and optimizing tissue regeneration and reconstruction.

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