Gallic acid‐gold nanoparticles enhance radiation‐induced cell death of human glioma <scp>U251</scp> cells

Zhou, Jing; Li, Minghe; Wang, Hongyuan; Yang, Zhuo; Zhou, Shaolong; Meng, Enping; Zhang, Hengwei; Liang, Wan; Hu, Weihua; Wang, Xinjun; Fu, Xudong

doi:10.1002/iub.2436

Cited by 18 publications

(8 citation statements)

References 32 publications

(60 reference statements)

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“…Ga, a trihydroxybenzoic acid, has an anti-cancer effect against a variety of cancer cells. At great concentrations, Ga induces a diminution in mitochondrial antioxidant activity, inhibits cell proliferation and decreases the power to repair the destruction of glioma T98G and U251 cells [13,14]. Ga decreased the proliferation and induced apoptosis through the activation of p-38 signaling and the decrease in ERK1/2 and JNK signaling in osteosarcoma cells [15].…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Enhances the Anti-Cancer Effect of Temozolomide in Human Glioma Cell Line via Inhibition of Akt and p38-MAPK Pathway

et al. 2022

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(1) Background: Temozolomide (TMZ), an oral alkylating agent, is used to treat malignant gliomas and other difficult-to-treat tumors. TMZ can enter the cerebrospinal fluid p.o. (per os) and does not need hepatic metabolism for activation of its use as a standard chemotherapeutic regimen after surgical resection of malignant glioma of the brain. However, the prognosis remains poor for most patients, and the survival rate is still unsatisfactory. Gallic acid (Ga) is a secondary metabolite existent in numerous plants. Ga shows various bioactivities, including antioxidant, anti-inflammatory, anticancer and antimicrobial effects. In this study, the latent enhanced anti-cancer efficacy of Ga in TMZ-treated U87MG cells (a human glioma line) was evaluated. (2) Methods: The U87MG cell line was cultured for 24 h. The cells were incubated with Ga alone, TMZ alone, or their combination for various time points. Cell viability and the drug combination index were evaluated by an XTT-based analysis and isobologram analysis, respectively. DNA destruction and intracellular reactive oxygen species (ROS) generation were analyzed by flow cytometer. The expression of various proteins was assessed via Western blotting. (3) Results: Compared with the action of TMZ alone or Ga alone, TMZ/Ga combination augmented the inhibition of cellular viability and apoptotic level in the U87MG glioma cell line. This enhanced anti-cancer effect correlated with the decreased expression of Bcl-2 and p-Akt, and corresponded with the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. In addition, Ga suppressed the TMZ-promoted ROS generation. (4) Conclusions: Ga can augment the anti-cancer effect of TMZ via the repression of Bcl-2 expression and Akt activation and the enhancement of the p38 MAPK pathway. Our results offer a novel probable approach for the medical treatment of malignant glioma.

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Section: Discussionmentioning

confidence: 99%

Gallic Acid Enhances the Anti-Cancer Effect of Temozolomide in Human Glioma Cell Line via Inhibition of Akt and p38-MAPK Pathway

et al. 2022

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“…Gallic acid (3,4,5‐trihydroxybenzoic acid, GA) is a well‐established antioxidant that shows potential anti-tumor capacity against GBM in vitro, however, the limited delivery method and poor drug availability restrict its further application. Through physical agitation adsorption, Zhou et al [ 117 ] constructed the GA@GNPs characterized with an average diameter of 23 ± 0.34 nm. The GA@GNPs system exhibited cytotoxic effect on GBM cells and sensitized the radiation‐mediated S and G2/M cell cycle arrest.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanoscale Drug Delivery Systems in Glioblastoma

Liu

Dong

et al. 2022

Nanoscale Res Lett

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Glioblastoma is the most aggressive cerebral tumor in adults. However, the current pharmaceuticals in GBM treatment are mainly restricted to few chemotherapeutic drugs and have limited efficacy. Therefore, various nanoscale biomaterials that possess distinct structure and unique property were constructed as vehicles to precisely deliver molecules with potential therapeutic effect. In this review, nanoparticle drug delivery systems including CNTs, GBNs, C-dots, MOFs, Liposomes, MSNs, GNPs, PMs, Dendrimers and Nanogel were exemplified. The advantages and disadvantages of these nanoparticles in GBM treatment were illustrated.

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“…GA exerts many beneficial properties such as antiinflammatory (BenSaad, Kim, Quah, Kim, & Shahimi, 2017), antioxidant (Yen, Duh, & Tsai, 2002), antifungal , and anticancer effects (Verma, Singh, & Mishra, 2013). Various studies have shown these anticancer effects in glioma (Jing et al, 2021;Lu et al, 2010;Musthafa et al, 2021). Paolini et al (2015) showed that cell viability and mitotic index of T98G glioma cells treated with different GA concentrations were reduced dose-dependently.…”

Section: Gallic Acidmentioning

confidence: 99%

Natural products in suppressing glioma progression: A focus on the role of microRNAs

Tabnak

Masrouri

Mafakheri

2022

Phytotherapy Research

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Glioma is one of the most common malignancies of the central nervous system. Due to inadequate response to the current treatments available, glioma has been at the center of recent cancer studies searching for novel treatment strategies. This has prompted an intensive search using linkage studies and preliminary evidence to gain efficient insight into the mechanisms involved in the alleviation of the pathogenesis of glioma mediated by miRNAs, a group of noncoding RNAs that affect gene expression posttranscriptionally. Dysregulated expression of miRNAs can exacerbate the malignant features of tumor cells in glioma and other cancers. Natural products can exert anticancer effects on glioma cells by stimulating the expression levels of tumor suppressor miRNAs and repressing the expression levels of oncogenic miRNAs. In this review, we aimed to collect and analyze the literature addressing the roles of natural products in the treatment of glioma, with an emphasis on their involvement in the regulation of miRNAs.

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Gallic acid‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells

Cited by 18 publications

References 32 publications

Gallic Acid Enhances the Anti-Cancer Effect of Temozolomide in Human Glioma Cell Line via Inhibition of Akt and p38-MAPK Pathway

Gallic Acid Enhances the Anti-Cancer Effect of Temozolomide in Human Glioma Cell Line via Inhibition of Akt and p38-MAPK Pathway

Nanoscale Drug Delivery Systems in Glioblastoma

Natural products in suppressing glioma progression: A focus on the role of microRNAs

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