Gallic Acid from Terminalia Bellirica Fruit Exerts Antidepressant-like Activity

Yadavalli, Chandra Sekhar; Kumar, G. Phani; Raghavan, Anilakumar Kandangath

doi:10.1007/s43450-020-00020-w

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…In parallel with a prior study, GA played an anti-apoptotic role by regulating some pro-apoptotic markers such as CASP-3 protein expression [ 45 ]. Based on our findings, we can imply that GA can significantly modulate the monoaminergic system by increasing the neurotransmitters levels and thus exerting a neuroprotective effect [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Mohamed

Hafez

2023

BMC Complement Med Ther

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Background Hepatic encephalopathy (HE) is a consequence of chronic or acute liver diseases. This study evaluates the combined effect of gallic acid (GA), and metformin (Met) on the liver and brain damage associated with HE. Methods Acute HE was induced by a single dose of thioacetamide (TAA) (300 mg/kg) as an I.P. injection. Treated groups received GA group (100 mg/kg/day, p.o), Met (200 mg/kg/day, p.o), or their combination for 25 consecutive days before TAA injection. Results The administration of TAA induced various biochemical and histopathological alterations. In contrast, treatment with GA either alone or combined with Met resulted in improved liver functions by the significant reduction in serum ALT, AST, and ALP activities, and ammonia levels. Inflammatory mediators; TNF-α, IL-6, and NFkβ levels were decreased by these treatments as well as apoptotic cascade via down-regulation of FAS and caspase-3 (CASP-3) expression in hepatic tissues. Furthermore, GA and Met either alone or combined protected the liver and brain tissues from damage by increased glutathione concentration while decreasing malondialdehyde. In addition, it was accompanied by the improvement of the brain neurotransmitter profile via the restoration of norepinephrine, dopamine, and serotonin levels. Based on our data, this is the first study to report a novel combined hepatoprotective and cognitive enhancing effect of GA and Met against TAA-induced acute liver and brain injury. Conclusion GA and Met combination resulted in a prominent improvement in HE complications, relative to monotherapy. Both agents potentiated the antioxidant, anti-inflammatory, and anti-apoptotic effects of each other.

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Section: Discussionmentioning

confidence: 99%

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Mohamed

Hafez

2023

BMC Complement Med Ther

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“…Some drugs improve depression-like behavior while working as an anti-inflammatory. Gallic acid from Terminalia Bellirica fruit inhibits CMS-induced serum corticosterone levels in mice treated with CMS, and exerts antidepressant-like effects in behavioral observations [ 158 ]. Likewise, Ginsenoside Rg1 is one of the constituents extracted from ginseng, with antidepressant and anti-inflammatory neuroprotective properties [ 159 ].…”

Section: Cx43 As a Mediator Of Neuroinflammation And Depressionmentioning

confidence: 99%

Connexin 43: An Interface Connecting Neuroinflammation to Depression

et al. 2023

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Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, is by far the most widely and ubiquitously expressed connexin in almost all vital organs. Cx43 forms gap junction channels in the brain, which mediate energy exchange and effectively maintain physiological homeostasis. Increasing evidence suggests the crucial role of Cx43 in the pathogenesis of MDD. Neuroinflammation is one of the most common pathological features of the central nervous system dysfunctions. Inflammatory factors are abnormally elevated in patients with depression and are closely related to nearly all links of depression. After activating the inflammatory pathway in the brain, the release and uptake of glutamate and adenosine triphosphate, through Cx43 in the synaptic cleft, would be affected. In this review, we have summarized the association between Cx43 and neuroinflammation, the cornerstones linking inflammation and depression, and Cx43 abnormalities in depression. We also discuss the significant association of Cx43 in inflammation and depression, which will help to explore new antidepressant drug targets.

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“…The utilization of natural products as prospective treatments for neurodegeneration was shown in several trials to have health-promoting benefits [ 7 ]. Some examples of medicinal plants and natural products that exert neuroprotective activities include Centella asiatica [ 8 ], Astragalus membranaceus [ 9 ], Panax ginseng [ 10 ], quercetin [ 11 ], and gallic acid [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

et al. 2023

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Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluate the effects of LAB on neuroprotection reported in the literature. Methods: A database search on Google Scholar, PubMed, and Science Direct revealed a total of 467 references, of which 25 were included in this review based on inclusion criteria which comprises 7 in vitro, 16 in vivo, and 2 clinical studies. Results: From the studies, LAB treatment alone or in probiotics formulations demonstrated significant neuroprotective activities. In animals and humans, LAB probiotics supplementation has improved memory and cognitive performance mainly via antioxidant and anti-inflammatory pathways. Conclusions: Despite promising findings, due to limited studies available in the literature, further studies still need to be explored regarding synergistic effects, efficacy, and optimum dosage of LAB oral bacteriotherapy as treatment or prevention against neurodegenerative diseases.

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Gallic Acid from Terminalia Bellirica Fruit Exerts Antidepressant-like Activity

Cited by 7 publications

References 27 publications

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Connexin 43: An Interface Connecting Neuroinflammation to Depression

Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

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