Gallic acid as a Sestrin (SESN2) activator and potential obesity therapeutic agent: A molecular docking study

Sousa, Jaciara Neves; Queiroz, Lorena dos Reis Pereira; de Paula, Alfredo Maurício Batista; Guimarães, André Luiz Sena; Lescano, Caroline Honaiser; Aguilar, Charles Martins; Pires de Oliveira, Ivan; Santos, Sérgio Henrique Sousa

doi:10.1016/j.gene.2023.147683

Cited by 3 publications

(1 citation statement)

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“…Initially, a few studies investigated the potential mediator of Sestrin2 in the field of tumor therapies, including several small molecules ( 212 ). Recently, natural-derived mediator of Sestrin2, such as Gallic acid ( 213 ) and eupatilin (Unpublished data of our research), are also indicated to be potential therapeutic agents of obesity and diabetes. Some antidiabetic medications are indicated to be involved in the regulation of Sestrin2 signaling in diabetes-associated conditions, some of which have been illustrated in the previous sections of this review.…”

Section: Possible Pharmacological Mediators Of Sestrin2mentioning

confidence: 88%

Sestrin2 in diabetes and diabetic complications

Zhang,

Luo,

et al. 2023

Front. Endocrinol.

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Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses. It plays critical roles in regulating a series of cellular events, such as oxidative stress, mitochondrial function and endoplasmic reticulum stress. Researches investigating the correlations between Sestrin2, diabetes and diabetic complications are increasing in recent years. This review incorporates recent findings, demonstrates the diverse functions and regulating mechanisms of Sestrin2, and discusses the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, hoping to highlight a promising therapeutic direction.

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Section: Possible Pharmacological Mediators Of Sestrin2mentioning

confidence: 88%