Galleria mellonella as a Model for the Study of Fungal Pathogens: Advantages and Disadvantages
Andrea Giammarino,
Nicolò Bellucci,
Letizia Angiolella
Abstract:The study of pathogenicity and virulence of fungal strains, in vivo in the preclinical phase, is carried out through the use of animal models belonging to various classes of mammals (rodents, leproids, etc.). Although animals are functionally more similar to humans, these studies have some limitations in terms of ethics (animal suffering), user-friendliness, cost-effectiveness, timing (physiological response time) and logistics (need for adequately equipped laboratories). A good in vivo model must possess some… Show more
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